Aram Chung (@ac467) header
Aram Chung (@ac467) profile picture

Aram Chung

@ac467

Prof at Korea Univ / Co-founder & CEO of MxT Biotech

 Seoul, Republic of Korea
aramchung.com
Joined October 2010
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  • Following218
  • Followers248
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Photo by Aram Chung (@ac467)Photo by Aram Chung (@ac467)Photo by Aram Chung (@ac467)Photo by Aram Chung (@ac467)Photo by Aram Chung (@ac467)Photo by Aram Chung (@ac467)Photo by Aram Chung (@ac467)Photo by Aram Chung (@ac467)Photo by Aram Chung (@ac467)Photo by Aram Chung (@ac467)
Aram Chung retweeted
Song Li (@songli_UCLA) profile picture
Song Li@songli_UCLAOct 23
Excited to share our new publication on physical regulation of genome! Millisecond compression of cells may induce changes in chromatin accessibility, which can be targeted by guide RNA for more efficient CRISPR activation of genes in heterochromatin. Thanks to all team members!
UCLA Broad Stem Cell (@UCLAstemcell) profile pictureUCLA Broad Stem Cell@UCLAstemcellOct 22
This microfluidic device squeezes cells as they pass through, loosening their tightly packed DNA so CRISPR tools can reach and switch on genes to make cell reprogramming more efficient. 🧫🧬 🔗 ow.ly/WKyt5100kpB #ResearchPowersProgresss #CellReprogramming #CRISPR
a transparent microfluidic device lays on top of a cell slide

ALT a transparent microfluidic device lays on top of a cell slide

Two fluorescence microscopy panels of cells with blue nuclei and green neuron-like cells. The left panel shows only a few sparse neurons with long, thin projections, while the right panel shows many more neurons with dense, branching networks.

ALT Two fluorescence microscopy panels of cells with blue nuclei and green neuron-like cells. The left panel shows only a few sparse neurons with long, thin projections, while the right panel shows many more neurons with dense, branching networks.

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In vivo engineering of CAR natural killer cells for immunotherapy using ligand-directed lipid nanoparticles nature.com/articles/s41587-0…
Image from Nature Biotechnology (@NatureBiotech)
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Aram Chung retweeted
ResearchHub (@ResearchHub) profile picture
ResearchHub
@ResearchHubSep 16
Jang et al., Microfluidic Mechanical Reactivation of Senescent Stem Cells, Small (Wiley, 9 September 2026), Konkuk University and Korea University, Seoul; figures cited from the bioRxiv preprint version. onlinelibrary.wiley.com/doi/…
Microfluidic Mechanical Reactivation of Senescent Stem Cells

Microfluidic Mechanical Reactivation of Senescent Stem Cells

This study introduces μ-CPR, a microfluidic platform that reactivates senescent stem cells through controlled mechanical stimulation, without chemical or genetic intervention. μ-CPR restores intrac...

onlinelibrary.wiley.com
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A study from @GDE_UTSW developed a polymer-lipid hybrid nanoparticle platform enabling programmable encapsulation and controlled organ-specific delivery of diverse RNA payloads. Learn more: go.nature.com/4zPsMbD.
Tunable polymers for polymer–lipid hybrid nanoparticles facilitate controlled organ-selective RNA...

Tunable polymers for polymer–lipid hybrid nanoparticles facilitate controlled organ-selective RNA...

Nature Chemical Engineering - A polymer–lipid hybrid nanoparticle platform enables programmable encapsulation and controlled organ-specific delivery of diverse RNA payloads. Through rational...

nature.com
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Microfluidics-mediated spatial control of mRNA lipid nanoparticles primes translation and enhances vaccine potency go.nature.com/4rpmX0I

Microfluidics-mediated spatial control of mRNA lipid nanoparticles primes translation and enhances...

Nature Biomedical Engineering - A microfluidic method restructures preformed lipid nanoparticles by inserting a metabolic-enhancing RNA into an internal peripheral compartment while relocating the...

nature.com
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Our recent work on microfluidic mechanical reactivation/rejuvenation of aged stem cells has been published in Small
Aging Science News (@AgingBiology) profile pictureAging Science News
@AgingBiologySep 15
Microfluidic Mechanical Reactivation of Senescent Stem Cells onlinelibrary.wiley.com/doi/…
Microfluidic Mechanical Reactivation of Senescent Stem Cells

Microfluidic Mechanical Reactivation of Senescent Stem Cells

This study introduces μ-CPR, a microfluidic platform that reactivates senescent stem cells through controlled mechanical stimulation, without chemical or genetic intervention. μ-CPR restores intrac...

onlinelibrary.wiley.com
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Lipid nanoparticles chart path beyond the liver nature.com/articles/s41587-0… [🔓read free with login]
Image from Nature Biotechnology (@NatureBiotech)
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For readers interested in the potential of in vivo CAR-T cell therapies for cancer and autoimmune diseases, here's a comprehensive review by pioneers in the field rdcu.be/koc33UDidsza nature.com/articles/s41573-0…
Image from Nature Reviews Drug Discovery (@NatRevDrugDisc)
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Excited to share that Spatial Hi-C-RNA is now out in @CellCellPress! It brings the 3D genome into spatial multi-omics by co-mapping chromatin architecture and gene expression in the same tissue section. Congrats to the whole team! cell.com/cell/fulltext/S0092…
Integrative spatial profiling of 3D genome organization and gene expression in tissue

Integrative spatial profiling of 3D genome organization and gene expression in tissue

Spatial Hi-C-RNA simultaneously maps genome architecture and gene expression from the same tissue, revealing how spatial genome organization shapes cellular identity, development, and tumor evolution...

cell.com
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”Genome-wide CRISPR screening identifies cellular factors controlling nonviral genome editing efficiency” Shivani Saxena, Meha Kabra [..] Krishanu Saha Nat Commun. 2026-08-13. doi.org/10.1038/s41467-026-7… #CRISPR #DDS
Genome-wide CRISPR screening identifies cellular factors controlling nonviral genome editing...

Genome-wide CRISPR screening identifies cellular factors controlling nonviral genome editing...

Nature Communications - Low editing efficiency of nonviral delivery in post mitotic tissues presents a challenge to the field of gene therapy. Here, authors dissect the genetic regulators of...

nature.com
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mRNA technology is one of the platforms being used for n-of-1 therapies. Read about its application in this and a range of other areas such as in vivo CAR-T cell therapies and cancer immunotherapies in this Review nature.com/articles/s41573-0… rdcu.be/fteeb
Image from Nature Reviews Drug Discovery (@NatRevDrugDisc)
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Aram Chung retweeted
Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggonerJul 10
Multifunctional-engineered NK cells overcome tumor immunosuppression by combining PD-L1 and HLA-E targeting and endogenous IL15 production 🇮🇹 nature.com/articles/s41392-0…
Image from Waggoner Lab (@LabWaggoner)
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Single-cell spatial pharmacobiology identifies conserved stromal barriers to therapeutic antibody delivery in human solid tumors go.nature.com/4atBJML
Image from Nature Biotechnology (@NatureBiotech)
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Aram Chung retweeted
Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopolMay 1
In cancer, activated T cells release abundant extracellular vesicles that transfer DNA to the nucleus of tumor and immune (dendritic) cells, turning tumors from cold to hot. An immunotherapy in the works. @Cancer_Cell sciencedirect.com/science/ar… sciencedirect.com/science/ar…
Image from Eric Topol (@EricTopol)
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CAR-X cell engineering dlvr.it/TSG6WV
Image from Nature Reviews Bioengineering (@natrevbioeng)
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A multiobjective AI model for LNP engineering enhances tissue-selective mRNA delivery go.nature.com/4ugPm9D
Image from Nature Biotechnology (@NatureBiotech)
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Aram Chung retweeted
Science News (@SciencNews) profile picture
Science News@SciencNewsApr 19
Macrophage senescence is a central driver of chronic inflammation in aging and metabolic liver disease, and a tractable therapeutic target.
Image from Science News (@SciencNews)
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Aram Chung retweeted
Cell (@CellCellPress) profile picture
Cell@CellCellPressApr 16
In the latest issue! Hallmarks of cancer—Then and now, and beyond dlvr.it/TS4Plc
Hallmarks of cancer—Then and now, and beyond

Hallmarks of cancer—Then and now, and beyond

Hanahan revisits the evolving framework of cancer hallmarks, synthesizing 25 years of conceptual refinement into a multidimensional view of tumor biology. This review highlights how aberrant capabi...

cell.com
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A lysosomal barcoding strategy to quantify endosomal escape of nucleic acids in vivo assesses the performance of branched ionizable lipids for potent liver delivery #NBTNV go.nature.com/4s4X7P7 rdcu.be/fdfzQ
Image from Nature Biotechnology (@NatureBiotech)
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Aram Chung retweeted
Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopolMar 25
Steady progress towards engineering immune cells in the body now for refractory myeloma , with major implications for many autoimmune diseases and cancers nature.com/articles/s41591-0… nature.com/articles/s41591-0…
Image from Eric Topol (@EricTopol)
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