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Martin Pera

@martinperaJAX

Professor @jacksonlab, stem cell biologist

 Bar Harbor, ME
jax.org/research-and-faculty/faculty/martin-pera
Joined July 2019
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Photo by Martin Pera (@martinperaJAX)Photo by Martin Pera (@martinperaJAX)Photo by Martin Pera (@martinperaJAX)Photo by Martin Pera (@martinperaJAX)Photo by Martin Pera (@martinperaJAX)Photo by Martin Pera (@martinperaJAX)Photo by Martin Pera (@martinperaJAX)Photo by Martin Pera (@martinperaJAX)Photo by Martin Pera (@martinperaJAX)
Spatial coordination in the codevelopment of the human urogenital system during organogenesis | Science science.org/doi/10.1126/scie…
Spatial coordination in the codevelopment of the human urogenital system during organogenesis

Spatial coordination in the codevelopment of the human urogenital system during organogenesis

The human urogenital system originates from a common embryonic domain, yet the mechanisms guiding its spatiotemporal coordination remain understudied. Here, we combined high-resolution spatial...

science.org
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Shao, D.D., Zhao, Y., Brew, J. et al. Perinatal elimination of genetically aberrant human cortical neurons. Nature (2026). doi.org/10.1038/s41586-026-1…
Perinatal elimination of genetically aberrant human cortical neurons

Perinatal elimination of genetically aberrant human cortical neurons

Nature - Single-neuron sequencing shows that widespread genomic abnormalities are common prenatally but largely eliminated around birth, indicating developmental genome quality control in human...

nature.com
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Bi, Y., Tu, Z., Zhang, X. et al. A three-dimensional human co-culture system reveals reciprocal embryo–endometrial adaptation at implantation onset. Nat Cell Biol (2026). doi.org/10.1038/s41556-026-0…
A three-dimensional human co-culture system reveals reciprocal embryo–endometrial adaptation at...

A three-dimensional human co-culture system reveals reciprocal embryo–endometrial adaptation at...

Nature Cell Biology - Bi, Tu, Zhang, Hu, Chen and colleagues co-culture human blastoids or blastocysts with endometrial assembloids to study cellular and transcriptional adaptations of embryonic...

nature.com
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Bi, Y., Tu, Z., Zhang, X. et al. A three-dimensional human co-culture system reveals reciprocal embryo–endometrial adaptation at implantation onset. Nat Cell Biol (2026). doi.org/10.1038/s41556-026-0…
A three-dimensional human co-culture system reveals reciprocal embryo–endometrial adaptation at...

A three-dimensional human co-culture system reveals reciprocal embryo–endometrial adaptation at...

Nature Cell Biology - Bi, Tu, Zhang, Hu, Chen and colleagues co-culture human blastoids or blastocysts with endometrial assembloids to study cellular and transcriptional adaptations of embryonic...

nature.com
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Accurate detection of sub-1% frequency somatic mutations by whole-genome sequencing: The American Journal of Human Genetics cell.com/ajhg/fulltext/S0002…
Accurate detection of sub-1% frequency somatic mutations by whole-genome sequencing

Accurate detection of sub-1% frequency somatic mutations by whole-genome sequencing

Accurate detection of rare somatic mutations is essential for studying human development, aging, and disease. Based on this study, we provide recommendations for sample quality assessment and best...

cell.com
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TorPause: Efficient Static Organ Preservation for Transplants biorxiv.org/content/10.64898…
TorPause: Efficient Static Organ Preservation for Transplants

TorPause: Efficient Static Organ Preservation for Transplants

Transplantation is limited by how long organs survive outside the body. Current methods slow metabolism or sustain physiological support, but neither eliminates ischemia-reperfusion injury, which...

biorxiv.org
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Lineage-specific and gestational age–dependent DNA methylation programming orchestrates human placental development | Science Advances science.org/doi/10.1126/scia…
Lineage-specific and gestational age–dependent DNA methylation programming orchestrates human...

Lineage-specific and gestational age–dependent DNA methylation programming orchestrates human...

The human placenta is essential for pregnancy, yet the dynamic regulation of its DNA methylome during development remains poorly understood. To address this, we generated a single base–resolution DNA...

science.org
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Defining early human developmental identity: A curated, cross-platform marker framework: Stem Cell Reports cell.com/stem-cell-reports/f…
Defining early human developmental identity: A curated, cross-platform marker framework

Defining early human developmental identity: A curated, cross-platform marker framework

Distinguishing genuine changes in developmental identity from transient transcriptional variation is a persistent problem in human pluripotent stem cell research. Dobner et al. curate and cross-val...

cell.com
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Panda, A., Carrillo, L., Balaton, B.P. et al. XIST drives X-chromosome inactivation and safeguards female extraembryonic cells in humans. Nat Commun 17, 10738 (2026). doi.org/10.1038/s41467-026-7…
XIST drives X-chromosome inactivation and safeguards female extraembryonic cells in humans

XIST drives X-chromosome inactivation and safeguards female extraembryonic cells in humans

Nature Communications - X-chromosome inactivation (XCI) silences one of the two X chromosomes in females, but its role in human development is unclear. Here, the authors show that human...

nature.com
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Epigenomic heterogeneity and spatial organization during human reprogramming biorxiv.org/content/10.64898…
Epigenomic heterogeneity and spatial organization during human reprogramming

Epigenomic heterogeneity and spatial organization during human reprogramming

Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) involves transcriptional and epigenomic remodeling, yet how these changes relate along productive and unsuccessful trajectories...

biorxiv.org
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The Genetic Discovery (GeDi) resource: Deep characterization of a multi-ancestry panel of human reference iPSCs for functional genomic studies biorxiv.org/content/10.64898…
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Multi-omic profiling of 85 iPSC lines from familial dementia reveals c… sciencedirect.com/science/ar…
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Cooperativity enables widespread role of low-affinity motifs in chroma… sciencedirect.com/science/ar…
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Wu, H., Hu, Y., Yu, H. et al. Modelling mouse embryogenesis from chemically induced totipotent stem cells. Nature (2026). doi.org/10.1038/s41586-026-1…
Modelling mouse embryogenesis from chemically induced totipotent stem cells

Modelling mouse embryogenesis from chemically induced totipotent stem cells

Nature - A mouse embryo model derived from chemically induced totipotent-like stem cells progresses through key developmental milestones, including gastrulation, embryonic axis formation,...

nature.com
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A fluctuation test for gastruloid heterogeneity: Cell cell.com/cell/fulltext/S0092…
A fluctuation test for gastruloid heterogeneity

A fluctuation test for gastruloid heterogeneity

Organoids grown side by side under identical conditions vary unpredictably, a longstanding obstacle to their use. Adapting the logic of a classic fluctuation test to gastruloids grown from single...

cell.com
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Huang, J., Li, R., Zeng, L. et al. Embryo selection by non-invasive preimplantation genetic testing for aneuploidy in women of advanced maternal age: a randomized, clinical trial. Nat Commun 17, 10634 (2026). doi.org/10.1038/s41467-026-7…
Embryo selection by non-invasive preimplantation genetic testing for aneuploidy in women of...

Embryo selection by non-invasive preimplantation genetic testing for aneuploidy in women of...

Nature Communications - Non-invasive preimplantation genetic testing for aneuploidy (niPGT-A) can detect embryo chromosomal aneuploidy by analyzing the cell-free DNA in embryo culture media, but...

nature.com
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Simplified in vitro generation of human gastruloids for modelling early development journals.biologists.com/dev/…
Simplified in vitro generation of human gastruloids for modelling early development

Simplified in vitro generation of human gastruloids for modelling early development

Summary: We present an optimized protocol for human gastruloid production that should enhance efficiency, reproducibility and affordability for future in vitro studies into early human post-implant...

journals.biologists.com
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WNT/β-catenin increases 3D chromatin mobility and reorganisation during posterior cell state transitions biorxiv.org/content/10.64898…
WNT/β-catenin increases 3D chromatin mobility and reorganisation during posterior cell state...

WNT/β-catenin increases 3D chromatin mobility and reorganisation during posterior cell state...

Chromatin mobility, the exploration of 3D conformations by the chromatin fibre, is implicated in transcription and DNA repair, and is thought to decrease progressively as cells differentiate. Here,...

biorxiv.org
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Capture of Post-Pluripotency Human Neuromesodermal and Neural Tube Axial Stem Cell States biorxiv.org/content/10.1101/…
Capture of Post-Pluripotency Human Neuromesodermal and Neural Tube Axial Stem Cell States

Capture of Post-Pluripotency Human Neuromesodermal and Neural Tube Axial Stem Cell States

The capture of pluripotent and adult tissue stem cells has transformed biomedicine, yet stable stem cell states between these developmental extremes have remained elusive. Here, we capture two human...

biorxiv.org
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Intra-uterine position modulates lifelong hippocampal neurogenesis and anxiety-related behavior biorxiv.org/content/10.64898…
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