A scientific journal devoted to publishing the most compelling research, opinion and analysis at the intersection of chemistry and biology.
New York, USA
Joined March 2009
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Our November issue is live!
nature.com/nchembio/volumes/…
The cover image depicts the common midwife toad. Comparative peptidomics is used to reveal disease dynamics and variation in host AMP defenses to understand how toad populations can survive disease outbreak.
APEX2 is shown to catalyze proximity labeling without hydrogen peroxide through the use of tetrazine-phenol probes, enabling spatial profiling of protein and RNA localization and interactions in vivo
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ADP-ribose induces neuronal ferroptosis through ENT2-mediated nucleotide rewiring, linking metabolism to neurodegeneration
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Chemogenetic activation of mitochondria counteracts the Warburg effect in tumor cells
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Diversification distal to the electrophile of covalent stereoprobes alters their protein interaction landscape, revealing GRPEL1-HSPA9 disruptors and nonorthosteric liganding events missed by cofolding models
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A new paper reveals how the bacterial defense enzyme S. aureus USI repeatedly scans and makes multiple DNA breaks, efficiently fragmenting invading genetic material
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A selective NVL inhibitor suppresses tumor growth by targeting ribosome biogenesis
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PUS7 pseudouridylation of noncoding RNA 7SK orchestrates human somatic cell reprogramming into iPS cells
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Proteome-guided drug discovery maps and mitigates therapeutic degrader toxicity
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High-resolution NMR spectroscopy of proteins in intact mitochondria
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QC6352, originally developed as a KDM4 inhibitor, exerts its anticancer activity in glioblastoma models primarily through inhibition of DHODH, a key enzyme in de novo pyrimidine biosynthesis
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Cell-cycle-driven noncanonical ubiquitination of METTL14 orchestrates RNA methylation
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Cryo-EM structures of RNA polymerase II (Pol II) with cisplatin-induced DNA interstrand crosslinks (ICLs) reveal how Pol II remodels cisplatin-ICLs, stalls transcription, and commits lesions to transcription-coupled repair
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A nontoxic proximity labeling method generating H2O2 in situ from D-amino acids enables protein and RNA proximity labeling and mapping RNA structural changes in vitro and in vivo
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SRSF1 modulates the dark nucleolar cap pH to restore nucleolar integrity and function
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A new Review highlights the mechanisms of molecules that disrupt translation in an amino acid or mRNA sequence-dependent manner
nature.com/articles/s41589-0…
Our October issue is live!
nature.com/nchembio/volumes/…
Inspired by the phases of the moon, the cover artwork uses light and darkness to depict pharmacological control of chimeric antigen receptor (CAR) T cells
Small-molecule inhibitors of S. aureus efflux pump NorA trap NorA in an outward-open state, preventing antibiotic efflux and restoring antibiotic susceptibility
nature.com/articles/s41589-0…
Allenes and alkynes can be biosynthesized via oxidative C(sp2)-demethylation of a prenyl group by fungal cytochrome P450s, expanding the catalytic repertoire of P450 enzymes
nature.com/articles/s41589-0…
