Paradromics Inc.

Speech BCIs are moving from proof of concept toward something people can live with outside the lab. A recent article from @ScienceNews traces the field from the first decoded words to fully implantable systems now in clinical study, including the investigational Connexus® BCI. Read more: sciencenews.org/article/brai…

The FDA approved an amendment to our Connect-One study protocol: participants no longer need to live within a four-hour drive of a clinical site. Eligible people across the U.S. may now be evaluated for the investigational Connexus BCI, if they can travel to a site. Read more: paradromics.com/news/paradro…

The Austin Business Journal recently profiled our founder and CEO @Matt_R_Angle: on leading ethically in BCI, roasting coffee in the garage, and the one book every founder should read. Read more: bizjournals.com/austin/news/… @MyABJ

Today, we announced a collaboration with @SiemensHealth to build an end-to-end imaging workflow for implantable BCIs. Through our partnership, structural MRI, functional MRI, vascular imaging, and CT scanning will now be combined to form one end-to-end process, from patient assessment and surgical planning to implantation and long-term outcomes. Read the full announcement: paradromics.com/news/paradro…

How far can human intention reach? At Abundance Longevity, founder and CEO @Matt_R_Angle introduced the Intent Horizon – that as neural interfaces, AI agents, and robotic systems grow in capability, the distance between what a person intends and what they can do will start to narrow, expanding the boundaries of what people can accomplish. Thank you to @PeterDiamandis and @Abundance360.

Performance or longevity. For years, it seemed like the field of BCI would have to choose between the two. Our accumulating preclinical data suggests otherwise: four years of stable neural recording and decoding in large animal models, with steady spike SNR and no electrode array migration. Read the full announcement here: paradromics.com/news/paradro…

Movement, speech, vision, focus, mood. While each activity originates from a different area of the brain, they all start with a signal. Capturing those signals at the source with a high-performing brain-computer interface (BCI) is the first step toward restoring the capabilities they drive. When a BCI is built on a modular architecture, like the Connexus® BCI, it can scale across multiple areas of the brain, expanding from essential functions such as speech and movement to broader human capabilities that could reshape how we interact with technology and the world around us. We recently created an interactive brain map to show where BCI research is headed. Explore the possibilities: paradromics.com/platform/#br…

At this year’s Detroit ALS Walk, we had the wonderful opportunity to meet the people we hope to serve, along with the families, caregivers, and advocates who support them every day. With more than 1,000 attendees, the community was able to surpass its fundraising goal and raise more than $250,000 for ALS research through the @alsassociation, one of the world’s leading funders of ALS research. At our booth, we shared how the Connexus® BCI is being designed to help restore communication for people who have lost the ability to speak. We were joined by @matthew_willsey, a neurosurgeon at the University of Michigan and one of the principal investigators leading the Connect-One Clinical Study. To Dr. Willsey: Thank you for standing with the Detroit community alongside us. The Connect-One Clinical Study is now enrolling. Learn more about the study here: paradromics.com/clinical-stu…

The New York Times recently reported on a first from our clinical trial: real-time conversation decoded directly from brain signals, whether our participant attempts speaking, whispers, or simply imagines the words. She has so much more to say, and so do we. Stay tuned. For now, dive into the full story: nytimes.com/2026/09/14/well/…

When we implanted the Connexus® Brain-Computer Interface (BCI) in June, we crossed a threshold into long-term human use. Today, we crossed another: The first participant in our Connect-One study is now choosing her own words and using neural activity to communicate in real time. She has a progressive motor neuron disease that has significantly affected her ability to speak. Through Connexus, she answered open-ended questions, spoke freely, and called her grandchildren, asking them questions and responding in a voice generated by the system. Asked what she would tell someone considering this research, she said: "Don't be afraid. It's a wonderful experience to be able to help others by your participation in the research study." Every word she intended was decoded exactly as she meant it. To our first participant: Thank you for your trust, your courage, and the words you have chosen to share with all of us. Our focus begins with restoring communication for people who have lost the ability to speak. Today, it meant that one woman could say what she wanted to say, in her own words, to the people she loves. Read the full release: paradromics.com/news/paradro… CAUTION: The Connexus® BCI is an investigational device limited by United States law to investigational use.

On the latest episode of The Business of Neurotech, @Matt_R_Angle makes the case that whoever constructs the highest data rate BCIs – and builds them around what patients are actually looking for – could some day end up delivering capabilities that extend far beyond restoration. Listen to their full conversation at the links below. Apple: podcasts.apple.com/us/podcas… Spotify: open.spotify.com/episode/3hx…

When someone is learning to speak with a brain-computer interface (BCI), the system must also learn from them and their unique linguistic patterns. See how BCI users shift from prompted words to language that’s fully their own, and what participants in our ongoing clinical study are working through today.

We've recently received an FDA approval letter that expands the types of computing devices that can be used with our brain-computer interface (BCI) system. Rather than being tied to a company-provided computer, clinical trial participants and future BCI users will be able to connect to the personal technology devices that are already a part of their daily lives. For people with severe motor impairment, this mobility is essential for enhancing their independence and creating a path for them to move through life just a bit more freely. Read the full release: paradromics.com/news/paradro… CAUTION: The Connexus® BCI is an investigational device limited by United States law to investigational use.

Big thank you to @BryanDChambers and the @CapitalFactory team for inviting Paradromics to Fed Supernova. @DARPA backed us when we were a small team with a big idea. A decade later, our BCI is in a human clinical trial, and we’re still building.

A little birdie told her. What could neural data tell us? Dr. Julie Elie recently decoded birdsong – specifically the language of zebra finches – by identifying the core calls that make up their vocabulary and what each one means. For more than a decade, she recorded the sounds the birds made and classified them by context and the bird that made them. She then used machine learning to analyze how information was encoded in each call. Finally, she confirmed her work by testing whether the finches themselves agreed with her classifications. For example, in one test, birds tapped a button to hear calls from their repertoire, with some calls followed by a seed reward. When they made mistakes, they tended to confuse calls that shared the same meaning rather than the same sound, suggesting they grasped what the calls actually meant. Her method is strikingly close to how neural decoding with an intracortical brain-computer interface (BCI) works. When someone attempts to speak, neurons in the motor cortex produce electrical signals associated with the intended word. Machine learning models then analyze the neural patterns recorded by the BCI to identify what is being expressed. And the person confirms, in real time, whether or not the intended meaning came through (no bird seed required). Both ask the same fundamental question: What is being communicated, and how do we learn to understand it? Decoding the brain is a vital part of the engineering behind restoring lost functionality. However, it may also teach us something larger: how thought itself is organized, providing us with a window into the brain unlike ever before. Read more: theguardian.com/science/2026…

What is needed to shift next-generation robotics from a promising prototype to something people with limb loss can access, afford, and rely on? This #SXSW2027, @phantom_neuro is proposing a panel, "Concept to Consumer: Scaling Access to Next-Gen Robotics," that seeks to shed light on the answer. The event – now open for community voting – will bring together Phantom Neuro CEO Connor Glass, Paradromics CEO @Matt_R_Angle, Aaron Holm of Wiggle Your Toes, patient and technology advocate Katie Meyer, and Ottobock. If this is a session you'd want to see on the @SXSW stage this coming spring, we'd be grateful for your vote. Cast yours here: participate.sxsw.com/flow/sx…

Long before we understand the rules of language, the brain learns how sounds fit together. Follow a single word, “cat,” as an intracortical brain-computer interface, or BCI, creates a new path from intention to expression. When you attempt to speak, neurons in the motor cortex produce electrical signals associated with the intended word. Machine learning models analyze the neural patterns and identify the likely building-block sounds: /k/, /a/, /t/. These sounds are called phonemes, and the English language contains about 40 of them. Language models then use those sounds and their context to predict the intended word: cat. All of this is engineered to happen in the space of a breath. Natural conversation moves at approximately 160 words per minute, and a speech BCI must keep pace with the rhythm and flow of real communication. Our latest blog explores how BCIs may use the natural building blocks of speech to turn attempted speech into expression. Read more: paradromics.com/blog/how-spe…

A brain-computer interface (BCI) may enable many different capabilities, but they all depend on one essential standard: it must work reliably for the people who depend on it, for years to come. This comes down to three factors, working together in harmony. Safety comes first, always. Performance is tied to capturing neural signals at the highest possible resolution and turning them into communication that conveys the user’s intent at a natural speed as opposed to feeling stilted or robotic. And durability means a device is engineered to last for years without a replacement. Without all three, BCIs will remain experimental. With them, they can become technology people trust and rely on for years. In our blog, Chief Scientific Officer Vikash Gilja, Ph.D, and Chief Medical Officer Stephen Ryu, M.D., break down the design choices behind the Connexus® BCI and highlight why these three pillars should set the standard for the field. Read on: paradromics.com/blog/buildin…