Pablo Sáez (@PSaez83) profile picture

Pablo Sáez

@PSaez83
Joined December 2021
  • Tweets16
  • Following74
  • Followers24
🎉🎉 Very happy that our paper “Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing” is out @scienceadvances science.org/doi/10.1126/scia… A thread on the main findings follows👇 @CNIC_CARDIO @SBEsp @SEBBM_es
Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing

Cell response to extracellular matrix viscous energy dissipation outweighs high-rigidity sensing

Viscosity blunts cell response to stiff matrices in agreement with a pull-and-hold model of molecular clutch-based mechanosensing.

science.org
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Pablo Sáez retweeted
SEMNI (@semni_social) profile picture
SEMNI @semni_social19 Oct 2023
Different positions available at UPC-BarcelonaTech, in the group of profs. Marino Arroyo and Pablo Saez, us14.campaign-archive.com/?u…
Image from SEMNI (@semni_social)
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thrilled to be part of it! @LaCaN_UPC @la_UPC
Pere Roca-Cusachs (@PCusachs) profile picturePere Roca-Cusachs@PCusachs14 Sep 2023
Replying to @PCusachs
The result of hard, detailed, insightful work by @ZanettaKechagia over several years, with great modelling by Pablo Sáez and Marino Arroyo (UPC), and in collaboration with @PWBDerksen, @AEloseguiArtola , and @XavierTrepat labs. Part of @Mechanocontrol project, funded by @EUeic.
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Our new work on nuclear mechanoprotection is now out: nature.com/articles/s41563-0…
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Happy to have this work published! Using the mouse hippocampus, we developed a model to predict local tissue mechanics. Thanks to Carlos Borau @M2BE_I3A @Nelda373 @Franze_Lab! 👇 sciencedirect.com/science/ar…
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We show that how individual tissue components assemble to each other, besides their local densities, is key to accurately modeling brain tissue mechanics
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New paper on durotaxis! We used clutch models and active gel theory to explain positive and negative durotaxis @softmatter See more 👇pubs.rsc.org/en/content/arti…
Positive, negative and controlled durotaxis†

Positive, negative and controlled durotaxis†

Cell migration is a physical process central to life. Among others, it regulates embryogenesis, tissue regeneration, and tumor growth. Therefore, understan

pubs.rsc.org
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We also propose how cell adhesion can be manipulated to control durotaxis (shift migration directions or arrest migration). And extended the model to describe haptotaxis!
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Our work on wrinkled fingers also featured at @CCMA_cat. @LaCaN_UPC @la_UPC @IMTech_UPC Per què s'arruguen els dits quan els posem en remull i què diu això sobre la nostra salut ccma.cat/324/per-que-sarrugu…

Per què s'arruguen els dits quan els posem en remull i què diu això sobre la nostra salut - 3CatInfo

És un fenomen quotidià i senzill, però fins i tot aquestes experiències tan conegudes serveixen als científics per fer estudis i extreure conclusions que poden tenir impacte positiu en la salut

3cat.cat
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How & why do our finger tips wrinkle? An old work featured @BBC_Future!! @LaCaN_UPC @IMTech_UPC @la_UPC
BBC Future (@BBC_Future) profile pictureBBC Future
@BBC_Future2 Jul 2022
Fingers and toes that wrinkle in water may have evolutionary benefits. bbc.com/future/article/20220…
Why your fingers wrinkle in water (and what it can reveal about your health)

Why your fingers wrinkle in water (and what it can reveal about your health)

The skin on our fingertips and toes shrivels like prunes when soaked in water. But is this an adaptation from our evolutionary past? And what can it reveal about our health today?

bbc.com
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