UCSFepilepsy (@UCSFepilepsy) header
UCSFepilepsy (@UCSFepilepsy) profile picture

UCSFepilepsy

@UCSFepilepsy

Based in the heart of San Francisco, we are dedicated to treating all forms of epilepsy across all ages using state-of-the-art treatments.

 San Francisco, California
epilepsycenter.ucsf.edu/
Joined June 2020
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Photo by UCSFepilepsy (@UCSFepilepsy)Photo by UCSFepilepsy (@UCSFepilepsy)Photo by UCSFepilepsy (@UCSFepilepsy)Photo by UCSFepilepsy (@UCSFepilepsy)Photo by UCSFepilepsy (@UCSFepilepsy)Photo by UCSFepilepsy (@UCSFepilepsy)Photo by UCSFepilepsy (@UCSFepilepsy)Photo by UCSFepilepsy (@UCSFepilepsy)Photo by UCSFepilepsy (@UCSFepilepsy)Photo by UCSFepilepsy (@UCSFepilepsy)
How does the brain decide whether to approach a reward or avoid a risk?⚖️ Research in Nat Neuroscience featuring Dr. Patrick Hullett uses human intracranial recordings to show opposing roles of medial and lateral orbitofrontal cortex in decision-making! nature.com/articles/s41593-0…
Intracranial recordings in humans reveal differential contributions of medial and lateral orbitof...

Intracranial recordings in humans reveal differential contributions of medial and lateral orbitof...

Nature Neuroscience - Intracranial recordings reveal oppositely tuned activity in the medial and lateral regions of the human orbitofrontal cortex during approach–avoidance decisions: the...

nature.com
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Patients and Clinicians!📢 Help shape how we measure epilepsy neuromodulation surgery success! Which aspects of daily life matter most to well-being and satisfaction after RNS, DBS, or VNS? Survey: myepilepsylife.org Your input will guide a new patient-centered outcome scale
Image from UCSFepilepsy (@UCSFepilepsy)
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HD Probes Show for the First Time How Epileptic ‘Brain Blips’ Occur ucsf.edu/news/2026/04/431796…
HD Probes Show for the First Time How Epileptic ‘Brain Blips’ Occur

HD Probes Show for the First Time How Epileptic ‘Brain Blips’ Occur

Epilepsy physicians Jon Kleen and Eddie Chang used high-resolution technology to see how cognition is disrupted in people with epilepsy and predict when it will occur. The new view points the way to...

ucsf.edu
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Just out in @NatureNeuro! Eyelash-sized Neuropixels probes show how brief electrical bursts between seizures ("interictal spikes") arise from consistent neurons in human cortex layers, hijack neurons used for cognition, & can be predicted up to 1-sec ahead nature.com/articles/s41593-0…
Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges

Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges

Nature Neuroscience - High-density single-neuron recordings in patients with epilepsy revealed interictal discharges are generated by structured laminar circuits. These circuits overlapped with...

nature.com
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Led by MD/PhD student Alex Silva @asilvaalex1, a collaboration between Jon Kleen/Kleen Lab @UCSFepilepsy and Edward Chang/Chang Lab @Changlabucsf @NeurosurgUCSF
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New @NatureNeuro study from @UCSFepilepsy, @ChangLabUcsf, @NeurosurgUCSF using human Neuropixels recordings was covered with a beautiful story in Science Magazine! Tiny probes make sense of abnormal bursts in the epileptic brain | Science | AAAS science.org/content/article/…
Tiny probes make sense of abnormal bursts in the epileptic brain

Tiny probes make sense of abnormal bursts in the epileptic brain

“Spikes” hijack neurons involved in cognition—and can be predicted up to 1 second in advance

science.org
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Extraordinary work by current (Dr. Nilika Singhal) and former (Dr. Joseph Sullivan) UCSF Pediatric Epilepsy faculty: Zorevunersen in Children and Adolescents with Dravet Syndrome | New England Journal of Medicine nejm.org/doi/full/10.1056/NE…
Zorevunersen in Children and Adolescents with Dravet Syndrome | NEJM

Zorevunersen in Children and Adolescents with Dravet Syndrome | NEJM

Dravet syndrome is a severe developmental and epileptic encephalopathy caused primarily by SCN1A haploinsufficiency. Risks of sudden unexpected death in epilepsy and cognitive deficits are higher a...

nejm.org
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In the Human Epilepsy Project multicenter cohort study, most individuals with newly diagnosed focal #epilepsy required over a year and multiple antiseizure medications to become seizure free. ja.ma/43vP03Q
Image from JAMA Neurology (@JAMANeuro)
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In the Human Epilepsy Project multicenter cohort study, most individuals with newly diagnosed focal #epilepsy required over a year and multiple antiseizure medications to become seizure free. ja.ma/3JuUTY6
Image from JAMA Neurology (@JAMANeuro)
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UCSFepilepsy retweeted
JAMA Neurology (@JAMANeuro) profile picture
JAMA Neurology@JAMANeuroMar 10
Among adults with newly diagnosed focal #Epilepsy, suicidality at diagnosis was associated with more than double the risk of future drug resistance vs mood or anxiety disorders alone. ja.ma/4sCVIPS
JAMA Neurology article titled \"Suicidality at Epilepsy Diagnosis and Future Treatment Resistance in Adults With Focal Epilepsy\" by Sarah N. Barnard, Jacqueline A. French, and Zhibin Chen, published online March 9, 2026.

ALT JAMA Neurology article titled \"Suicidality at Epilepsy Diagnosis and Future Treatment Resistance in Adults With Focal Epilepsy\" by Sarah N. Barnard, Jacqueline A. French, and Zhibin Chen, published online March 9, 2026.

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Remarkable work by Dr. Joseph Sullivan during his time at UCSF!
NEJM (@NEJM) profile pictureNEJM
@NEJMMar 8
A video shows a patient with Dravet syndrome performing activities of daily living before and after treatment with zorevunersen. Watch the full video and read the full report: nejm.org/doi/full/10.1056/NE…
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UCSFepilepsy retweeted
Manu Hegde (@hegdenothedge) profile picture
Manu Hegde@hegdenothedgeMar 9
Suicidality and Treatment Resistance in Focal Epilepsy jamanetwork.com/journals/jam… Proud to be a part of this important work
Suicidality and Treatment Resistance in Focal Epilepsy

Suicidality and Treatment Resistance in Focal Epilepsy

This cohort study investigates the association between psychiatric disturbance (current or past suicidality, mood, and/or anxiety disorder) at epilepsy diagnosis with the risk of developing future...

jamanetwork.com
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New work by adult epileptologist/neuroscientist extraordinaire Patrick Hullett MD, PhD and the @ChangLabUcsf -- showing the human frontal lobe receives fast, low-level speech information in parallel with early speech areas! Published in @NatureComms 🎉🧠 nature.com/articles/s41467-0…
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Our own Sharon Chiang, MD, PhD has been selected as the recipient of the ANA-Persyst Professional Development Award! This award is provided to assist early career academics specializing in the field of epilepsy reach their goals of becoming clinician neuroscientists - Congrats!🎉
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Thrilled to welcome the following neurology residents to the UCSF Epilepsy Fellowship, starting 2026! Divyesh Doddapaneni, University of Colorado Rachel Eby, Oregon Health Sciences University Brandon Wei, Houston Methodist Erin Yeagle, UCSF Congratulations! @UCSFepilepsy #NRMP
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"It can be hard to figure out where that bad spot or network is and precisely how far it extends, especially when brain imaging studies look normal. Our thought was similar to high-resolution TVs—more detail might be better." medicalxpress.com/news/2025-…
Improving epilepsy surgery by pinpointing where seizures begin

Improving epilepsy surgery by pinpointing where seizures begin

When you replace an older cell phone or TV with a new high-resolution device, the visuals can be strikingly different—all of a sudden you have improved clarity and can see new details. Now, UC San...

medicalxpress.com
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Are HIGHER densities of intracranial contacts on depths/strips/grids BETTER for finding the seizure-onset zone and its margins? A carefully controlled study by the Kleen Lab @UCSF is published today in @TheLancet's open access journal @eBioMedicine! thelancet.com/journals/ebiom…
Image from UCSFepilepsy (@UCSFepilepsy)
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Congrats to 1st-author Ebenezer Chinedu-Eneh!!! 🎉🧠
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UCSF Epilepsy Division Chief Vikram Rao MD PhD featured in The Academic @theacademic0 🎉
The Academic (@theacademic0) profile pictureThe Academic@theacademic05 Oct 2024
How can people living with #epilepsy gauge the likelihood of future #seizures? Academic: Vikram Rao @UCSFepilepsy @ucsfhealth @usfca @ChangLabUcsf @NeurosurgUCSF
TheAcademic Publishing Form (Responses) TheAcademic Publishing Form (Responses) 100% 10 N112 Question: How can people living with epilepsy gauge the likelihood of future seizures? Answer: Patterns of communication between brain regions are measurable in brief snapshots of brain activity and help determine the chance of a seizure occurring in the next day. Like weather forecasts, seizure forecasts have potential to reduce uncertainty by helping people with epilepsy anticipate inclement events. Question: How can people living with epilepsy gauge the likelihood of future seizures? Answer: Patterns of communication between brain regions are measurable in brief snapshots of brain activity and help determine the chance of a seizure occurring in the next day. Like weather forecasts, seizure forecasts have potential to reduce uncertainty by helping people with epilepsy anticipate inclement events. Turn on screen reader support

ALT TheAcademic Publishing Form (Responses) TheAcademic Publishing Form (Responses) 100% 10 N112 Question: How can people living with epilepsy gauge the likelihood of future seizures? Answer: Patterns of communication between brain regions are measurable in brief snapshots of brain activity and help determine the chance of a seizure occurring in the next day. Like weather forecasts, seizure forecasts have potential to reduce uncertainty by helping people with epilepsy anticipate inclement events. Question: How can people living with epilepsy gauge the likelihood of future seizures? Answer: Patterns of communication between brain regions are measurable in brief snapshots of brain activity and help determine the chance of a seizure occurring in the next day. Like weather forecasts, seizure forecasts have potential to reduce uncertainty by helping people with epilepsy anticipate inclement events. Turn on screen reader support

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Read about a "neural heartbeat in the hippocampus" that forecasts epileptic seizures, featured in this recent article in The Academic (alluding to the groundbreaking study published this summer in Nature Medicine by Vikram Rao, @ANKhambhati, and others): theacademic.com/snapshots-of…
Snapshots of a neural heartbeat in the hippocampus forecast epileptic seizures - The Academic

Snapshots of a neural heartbeat in the hippocampus forecast epileptic seizures - The Academic

Forecasting seizures using neural snapshots offers new hope for epilepsy patients, potentially improving their quality of life and safety.

theacademic.com
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