DatoCiencia

🔋 New Article: From mitochondrial transfer in skin cells to mitochondrial transplantation for tissue repair Can understanding how mitochondria naturally move between cells help us design new regenerative strategies? After six years of work, our new study in the Journal of Translational Medicine follows this question from fundamental cell biology to preclinical tissue repair. 🔬 We found that mitochondrial transfer in skin is selective and context-dependent. One of the clearest interactions was a strong increase in mitochondrial transfer from melanocytes to keratinocytes following UVR exposure. This observation raised a broader question: 💡 Could understanding which cells naturally exchange mitochondria—and under which conditions—help identify where artificial mitochondrial transfer may be therapeutically useful? 🔋 We then tested mitochondria isolated from mesenchymal stromal cells and observed that MSC-derived mitochondria reduced UVR-induced oxidative stress and stimulated fibroblast proliferation. 🐭🐷 Finally, we moved from cells to mouse and pig wound-healing models, where mitochondrial transplantation showed encouraging preclinical evidence of regenerative potential, including improved collagen organization and increased cellular proliferation. 🧬 Endogenous mitochondrial transfer → 🔋 Artificial mitochondrial transfer → 🩹Preclinical mitochondrial transplantation For us, this work represents an important step toward understanding not only how mitochondria move between cells, but also how this biology might eventually be harnessed for tissue repair and regenerative medicine. It has been a six-year effort built through teamwork, students, collaborators, and many experiments across different biological models. 🙏 Above all, I am grateful to God for the strength, guidance, and opportunity to carry this work forward. My deepest thanks also go to our incredible team at the lab, @USFQ_Ecuador @AFResearchLab @AFOSR for supporting this research journey. 📖 Full article: link.springer.com/article/10… @Madam_Mito @PathfinderEq @heniek_htw @MitoSenseInc @MitoResearch @Mito_Therapy @MitochondriaNe1 @MitoSociety @Mito_News @CEDIAec @edicionmedEC @KunaEcuador @DatoCienciaEC