The American Society for Microbiology’s first broad-scope, online-only, open-access journal. Contact us at [email protected].
Washington, DC
Joined July 2009
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New #mBio study overturns long-standing dogma: human #macrophages and neutrophils can phagocytose amoebae after all. But #Entamoeba histolytica has evolved a “kiss and run” escape strategy. doi.org/10.1128/mbio.02294-2… #amoeba #eukaryotes
mBio retweeted
This #mBio study shows that the genome of T. gondii lacks conserved genes for iron transport and storage and these host cell proteins, providing insight into essential functions associated with parasite theft of host iron acquisition and storage proteins. asm.social/39c
ALT T. gondii lacks iron transport or storage genes, but host transferrin receptor and ferritin localize to the parasite.
A new series of reaction-hijacking inhibitors shows potent and specific inhibition of the #malaria parasite. The parasite's enzyme for loading tRNA with asparagine is tricked into generating an adduct that poisons the enzyme's activity. doi.org/10.1128/mbio.01884-2… @CreekLab
🎉Kudos to Rosa Lilian Díaz Chávez on winning the mBio poster prize at ISFUS 2026! Lily is a PhD student in molecular biology at IPICYT, Mexico, studying how mitochondrial function & epigenetic mechanisms contribute to antifungal adaptation in C. glabrata. isfus2026.wordpress.com/
An RNA-binding protein exclusively expressed by #Cryptosporidium female gametes is essential to produce infective oocysts and sporozoites. doi.org/10.1128/mbio.01991-2… @hostmicrobe @striepenlab #parasitology #apicomplexan
How does C. difficile adapt to a stressed gut? A σB-dependent small regulatory RNA (sRNA) links stress responses to sporulation, metabolism, and infection outcomes. doi.org/10.1128/mbio.01923-2…
Antibiotic failure isn’t always about resistance. This mBio mGem explores how differences in bacterial growth rates may help chronic infections survive treatment. doi.org/10.1128/mbio.01926-2… @whiteleylab #AMR
How conserved are bacterial transcription elongation networks? Surprisingly, key NusG, NusB, S10, and Rho interactions are maintained across diverse bacteria despite differing mechanisms. doi.org/10.1128/mbio.02180-2… @BabitzkePaul
How does lumpy skin disease virus evade immune detection? This mBio study identifies LSDV003, a viral protein that traps MHC-I inside cells, helping the virus escape T-cell surveillance. A potential target for improved vaccines and antiviral strategies. doi.org/10.1128/mbio.02359-2…
A long-standing view holds that #Leptospira cannot use glucose. Ozuru et al. show that pathogenic Leptospira unlocks glucose uptake and metabolism at host-like temperature, revealing a previously hidden metabolic adaptation. doi.org/10.1128/mbio.01814-2… @papinsysbio
Antiretroviral therapy (ART) suppresses HIV replication, but not all HIV activity is silent. This new mBio mGem shows how persistent HIV-1 transcription in myeloid cells may fuel chronic inflammation. doi.org/10.1128/mbio.03340-2… #HIVResearch #Immunology
Applications are now open for the 2027-28 mBio Early-Career Editorial Board! Grow as a peer reviewer through training & hands-on experience, learn about scholarly publishing, and be mentored by mBio Editors. Apply by December 11, 2026. Spaces are limited! journals.asm.org/journal/mbi…
Obesity may undermine #antibiotics in ways beyond drug resistance. Acetate restored immune function, sensitized A. baumannii to tobramycin & improved bacterial clearance. A #microbiota-derived metabolite shows promise as an antibiotic adjuvant. doi.org/10.1128/mbio.01630-2… #IITRoorkee
mBio retweeted
Loss of the O-specific antigens (OSA) in P. aeruginosa is common in isolates from cystic fibrosis lungs. Strains lacking OSA become more adhesive, limiting their motility but enhancing biofilm formation. Learn more in #mBio: asm.social/37X
ALT Biofilm formation in the O-specific antigen mutants.
Over 100,000 deaths yearly, yet no approved cryptococcal vaccine. This mBio study used CD4+ T-cell epitope mapping to build a hybrid #vaccine that protected mice from lethal challenge. doi.org/10.1128/mbio.02176-2… #Cryptococcus @UMassChan #mycology
Can we predict resistance before it emerges? By mapping NDM-1 evolution under new β-lactam therapies, Romero et al. identify likely escape routes and more robust treatment options. doi.org/10.1128/mbio.02280-2… #AMR #NDM #antibiotics @TatoVila_1962
mBio retweeted
In #mBio: a modular, extensible platform for the generalizable implementation and optimization of genetic code expansion (GCE) in phylogenetically diverse bacteria, based on the host-agnostic serine recombinase-assisted genome engineering toolkit. asm.social/37A
ALT Overview of systems employed in this work. (A) Overview of genetic code expansion (GCE). Elements in red and blue represent engineered translational components that act orthogonally to endogenous translation (elements in gray) to produce site-specifically modified protein. (B) Overview of serine-recombinase-assisted genome engineering (SAGE), where serine-recombinases encoded on non-replicating plasmids facilitate the insertion of attP-containing target plasmids into cognate attB-sequences that have been installed into the host chromosome.
Bacteria may be far better at scavenging sulfur than we realized. New research in mBio shows methylthio-alkane reductases are widespread across diverse anaerobes, expanding known sulfur acquisition pathways. doi.org/10.1128/mbio.01493-2…
Corticosteroids fuel oral #candidiasis by suppressing protective type-17 immunity, not by inducing #interferon-γ-driven inflammation. New insights into host defense against #Candida albicans. doi.org/10.1128/mbio.02170-2… #corticosteroids
What happens when microbiologists follow the molecules? This mBio review by @GargLab_GT showcases how #metabolomics is illuminating microbial physiology, communities, and host-microbe interactions. doi.org/10.1128/mbio.01913-2… @Neha10GT #metabolites
