David E Cook (@1DEcook) header
David E Cook (@1DEcook) profile picture

David E Cook

@1DEcook

Associate Prof. KSU Plant Path | How do plants and microbes respond to each other? | Generally curious and a contrarian | #BLM

 Manhattan, KS
Joined February 2013
  • Tweets1.6K
  • Following754
  • Followers1.5K
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Photo by David E Cook (@1DEcook)Photo by David E Cook (@1DEcook)Photo by David E Cook (@1DEcook)Photo by David E Cook (@1DEcook)Photo by David E Cook (@1DEcook)Photo by David E Cook (@1DEcook)Photo by David E Cook (@1DEcook)Photo by David E Cook (@1DEcook)Photo by David E Cook (@1DEcook)Photo by David E Cook (@1DEcook)
David E Cook retweeted
Eric Nguyen (@exnx) profile picture
Eric Nguyen
@exnxOct 20
For years, AI for biology has been built one problem at a time. Separate models for proteins, gene regulation, genetic disease, and molecular design We believe this is changing Omnii-1 unifies 28 biological modalities, spanning DNA, RNA, proteins, epigenomics, and more, in a single model trained on trillions of tokens of biological data
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Replying to @UCSanDiego
@UCSanDiego biologists have created a transformative new way to monitor genes. The game-changing tool known as RUBY is an inexpensive, easy-to-use technology that allows researchers to visualize genetic changes. go.ucsd.edu/4nEJswk #BehindEveryBreakthrough
Image from UCSD BioSciences (@ucsdbiosciences)
Image from UCSD BioSciences (@ucsdbiosciences)
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Open postdoc position in the Cook Lab at KSU, funded to study heterochromatin-based genome regulation in fungal plant pathogens. careers.k-state.edu/jobs/fel…
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David E Cook retweeted
Jun (@Jun91487218) profile picture
Jun@Jun9148721815 Nov 2024
Excited to share our latest discovery on distinct evolutionary trajectories following RNAi loss in Cryptococcus, now published in @PNASNews! Huge thanks to @Cojola429, @VikasYadavSci, @magwenelab, @DukeHeitman and everyone who supported this work! pnas.org/doi/10.1073/pnas.24…
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David E Cook retweeted
Gitta Coaker (@GittaCoaker) profile picture
Gitta Coaker@GittaCoaker1 May 2024
Excited to share our preprint! Plant tandem kinase proteins (TKPs) provide resistance to Magnaporthe by direct effector binding. TKPs are an emerging class of disease resistance proteins. Thanks to @YiChangSung1 @LAntheline @FahimaTzion @AsukeSoichiro biorxiv.org/content/10.1101/…
Direct binding of a fungal effector by the wheat RWT4 tandem kinase activates defense

Direct binding of a fungal effector by the wheat RWT4 tandem kinase activates defense

Plants have intricate innate immune receptors that detect pathogens. Research has intensely focused on two receptor classes recognizing external and internal threats. Recent research has identified a...

biorxiv.org
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We are looking for a postdoctoral researcher to join our team @MPI_Bio. If you're interested in adaptive evolution of plant pathogens and supernumerary chromosomes 🧬please apply! Please RT 📢 For info about ongoing projects check out our webiste: bio.mpg.de/302180/thorsten-l…
Image from Thorsten Langner (@ThorstenLangner)
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Could not be any happier to hear about the new research from @Jun91487218 Jun Huang now with @DukeHeitman. Identification of novel TE activity in RNAi mutants #Fungal24
Image from David E Cook (@1DEcook)
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Cool talk of @kseniakrasileva on fungal effectors and fungal immune systems at #Fungal24
Image from Team Thomma @teamthomma.bsky.social (@Team_Thomma)
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David E Cook retweeted
Michael F Seidl (@MFSeidl) profile picture
Michael F Seidl@MFSeidl16 Mar 2024
Super nice talk by @AvWesterhoven on her most recent work on genome evolution in Fusarium oxysporum nph.onlinelibrary.wiley.com/… @BinfUtrecht @UUBeta @phytoWUR #proudPI
Segmental duplications drive the evolution of accessory regions in a major crop pathogen

Segmental duplications drive the evolution of accessory regions in a major crop pathogen

Many pathogens evolved compartmentalized genomes with conserved core and variable accessory regions (ARs) that carry effector genes mediating virulence. The fungal plant pathogen Fusarium oxysporum...

nph.onlinelibrary.wiley.com
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And now we are talking about one of my favourite subjects: dikaryon genomics! @Figueroa_MM covering it all from Robigus to high-throughput effector screening in plant protoplasts #Fungal24
Image from Jana Sperschneider (@JSperschneider)
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Kicking off #Fungal24 is Thorsten @ThorstenLangner on genome evolution of the rice blast fungus #CelebratingAlumni #2speedgenome
Image from Sophien Kamoun (@KamounLab)
Image from Sophien Kamoun (@KamounLab)
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David E Cook retweeted
Frank Menke (@Frank_Menke) profile picture
Frank Menke@Frank_Menke13 Mar 2024
Kicking off #Fungal24 plenary session 1 @ThorstenLangner on genome evolution in fungi
Image from Frank Menke (@Frank_Menke)
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Fantastic plenary presentation at #Fungal24 by @YukiyoSato3 as chairs choice on how the fungus #Verticillium adapts to environmental changes through large-scale genomic rearrangements. What a great performance! 🥳 #ProudPI
Image from Team Thomma @teamthomma.bsky.social (@Team_Thomma)
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Next up #magnafest #fungal24 is Angus Bucknell from @TheSainsburyLab talking about prediction of effector function through structural homology.
Image from Thorsten Langner (@ThorstenLangner)
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Our next speaker at #Magnafest #Fungal24 is Michael Richter from @WilsonLab talking about the role of acyl-coA binding protein Acb1 in biotrophic membrane biogenesis.
Image from Thorsten Langner (@ThorstenLangner)
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Ayden McVey from @1DEcook lab kicking off #Magnafest #Fungal24 talking about epigenetic regulation during blast fungus infection.
Image from Thorsten Langner (@ThorstenLangner)
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📢Happy to see our latest publication 📜on the 3D genome of #Verticillium, previously on @biorxivpreprint, now online in @NatureComms: rdcu.be/dzvgv 🎉🍾. Great work by @phyTorres @VTracanna @HM_Kramer @FiorinLorencini @1DEcook & @MFSeidl
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Some highlight #PAG31 thus far Most useful tool: mPong-Cas9 transposase for targeted genome insertion @Slotkin_Lab assets.researchsquare.com/fi… Best named software: Swift-TE, short read TE analysis @ClaireCodes Interesting Biology: Evo Epigenome-recruited DNA repair @Grey_Monroe
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This paper is SUPER interesting for our field... Had completely missed it! Repair of DNA double-strand breaks leaves heritable impairment to genome function biorxiv.org/content/10.1101/…
Repair of DNA double-strand breaks leaves heritable impairment to genome function

Repair of DNA double-strand breaks leaves heritable impairment to genome function

Upon DNA breakage, a genomic locus undergoes alterations in 3-D chromatin architecture to facilitate signaling and repair. While cells possess mechanisms to repair damaged DNA, it is unknown whether...

biorxiv.org
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David E Cook retweeted
Eduard Akhunov (@eakhunov) profile picture
Eduard Akhunov@eakhunov22 Nov 2023
Happy to see this paper out! @zitongyuzt CRISPRed wheat gluten genes to achieve 47-fold reduction in immunotoxicity; step towards developing safer wheat-based products! @KSUPlantDr @KansasWheat @KStateResearch #NIFAImpacts onlinelibrary.wiley.com/doi/…
CRISPR‐based editing of the ω‐ and γ‐gliadin gene clusters reduces wheat immunoreactivity without...

CRISPR‐based editing of the ω‐ and γ‐gliadin gene clusters reduces wheat immunoreactivity without...

Wheat immunotoxicity is associated with abnormal reaction to gluten-derived peptides. Attempts to reduce immunotoxicity using breeding and biotechnology often affect dough quality. Here, the multip...

onlinelibrary.wiley.com
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