AIRCaseCollab

1/ How do you manage a 64 y/o woman w/ long-standing #HAE Type I❓ Drs. Lumry & West walk through a real-world case in this new #HAE CME activity 🎓For more free CME, visit: integrityce.com Follow this 🧵 to review the #medcase #HAE #immunology

Resource Tweet #2 📊 Use AECT to assess control, even infrequent attacks = burden 🎯 Align treatment w/ patient goals & validated evidence

Resource Tweet #1 🤝 Shared decision-making = better outcomes

12/ Want more #HAE education❓ 👀 Check out the on-demand activity! 🔗 Visit: integrityce.com/HAEOnDemand 🎓 Earn FREE #CME credits

11/ 🗝️ takeaways from the case❓ 🎥 Listen to our faculty summarize takeaways & best practices ⤵️

10/ Monitoring matters: 🧠 Safety after long-term danazol use 📅 Ongoing follow-up is key 🎥 Listen to Drs. Lumry & West discuss key considerations for patient monitoring ⤵️

9/ 📊 What type of monitoring will the patient require going forward❓ A. Annual liver ultrasound ​ B. Routine hematologic monitoring​ C. Annual pulmonary function testing​ D. No monitoring needed after discontinuation of danazol

8/🎥 Hear Drs. Lumry & West discuss optimizing on-demand treatment & prophylactic regimens ⤵️

7/ 📊 What change, if any, would you make to the patient’s prophylactic regimen❓ A. Switch to C1-INH ​ B. Switch to lanadelumab​ C. Switch to berotralstat​ D. No change

6/ 📊 What change, if any, would you make to the patient’s current on-demand regimen❓ A. Switch to ecallantide ​ B. Switch to sebetralstat​ C. No change

5/ Findings from her physical exam & previous tests are summarized below 👇

4/ Patient undergoes a comprehensive evaluation: ✅ ROS & vitals normal, except history of present illness

3/ Medical history: 📌 Current meds: Fluticasone nasal spray, pantoprazole, pravastatin, & hydrochlorothiazide 😷 Comorbidities: Hyperlipidemia, hypertension, GERD, allergic rhinitis 🪡 Surgical: Tonsillectomy & 2 uncomplicated vaginal deliveries 👩‍👧‍👧 Family: Sister w/ swelling; children unaffected

2/ Meet our patient: 👩‍⚕️ 64 y/o woman diagnosed w/ HAE in 1993 🔁 Recurrent peripheral swelling since age 30 😣 Attacks sometimes preceded by red non-urticarial rash & often triggered by stress 💊 Treated w/ danazol, C1-INH, & icatibant 🩸 Developed polycythemia → managed w/ blood donation

Join us NOW for this live webcast & earn up to 1.0 credit! To view CME Information, interact w/ presenters, & claim credit, visit integrityce.com/HAEReg5 Supported by an educational grant from Takeda Pharmaceuticals U.S.A., Inc.

Resource Tweet #2 🛠️ Use tools like AECT to assess #HAE control, even w/ infrequent attacks

Resource Tweet #1 ❗ Avoiding triggers is key to managing #HAE Common triggers: 🔹 Minor trauma 🔹 Surgery/dental work 🔹 Stress 🔹 Estrogens/birth control 🔹 Pregnancy

14/ Want more #HAE education❓ 👀 Be on the lookout for the on-demand activity launching on Friday, October 31st 🎓 Earn FREE #CME credits 🔗 Visit: integrityce.com and join our mailing list to stay up to date!