Associate Professor @UCSF Microbiology&Immunology | Dad, Husband| Studying the dynamic epigenome with Chromatin Biochemistry/ Biophysics and Single Cell Biology
@UCSF | G W Hooper Foundation
Joined July 2018
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Join us for Bay Area Chromatin Club ! First in person event for 2026- UCSF Genentech Hall, March 5, 1-5pm. Speakers from across the Bay. Bring a poster, hang out with old friends and make new ones! Register here and please RT:
urldefense.com/v3/__https://…$
Kudos to Dana Kennedy, for making this lovely, pressed flower cover image for her paper. "Pressed-flower art representing heterochromatin gene silencing in Schizosaccharomyces pombe. Each distinct flower symbolizes HP1/Swi6, Clr4, nucleosomes, and post-translational (cont)
Tour de force by @drkennedy93 !
doi.org/10.1093/nar/gkaf1244
HP1/Swi6 phosphorylation is required for H3K9 trimethylation spreading but not nucleation. Why? Phosphorylation tunes the bulk chromatin affinity into a regime where HP1 is specific for the H3K9me3 state and not H3K9me0.
Question re: @BioRadLifeSci 491 Prep Cell: I have one, but need elution frit and tubing kit. Those are out of stock. The best advice I got from the sales rep is buy a whole new one ($7000) to get those <$100 items. Anyone know where to get such accessories? so far came up empty.
Throughout my PhD working on phytochrome signaling I always looked up to and took inspiration from Dr Chory creative and important work. I am truly sad for this loss. A giant in the field.
A preprint from the lab led by graduate student Dana R Kennedy.
doi.org/10.1101/2024.10.25.6…
Over 20 years ago, the Eissenberg lab showed that phosphorylation of HP1 is important for its silencing function. Why? Key observations from our study in fission yeast:
7. We suspect that increased oligomerization by NTE phos further partitions the protein into heterochromatin foci and supports spreading. Thanks to great collaborators Rob Maxwell at UC Berkeley, the Chang lab’s @JoelLemiere and Catherine Tan, and Julian Braxton, now at Caltech.
Awesome!
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
al-sadylab retweeted
Very excited to be hosting @levine_lab for the Basic Science a seminar at UCSF tomorrow ! Please everyone stop by you are in for a treat !