Assistant Prof. at the Centre for Programmable Biological Matter, Durham University Interested in everything protein design Views are my own He / Him
Durham University
Joined July 2016
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Keep an eye out!
52nd New Phytologist Symposium: "Structural biology at the plant–microbe interface"
Tübingen, 21–25 Mar 2028
Crystallography, cryo-EM, cryo-ET, structure prediction & protein design
Applications open late spring 2027
newphytologist.org/events/52…
Adam Bentham retweeted
🎉 𝐌𝐞𝐞𝐭 𝐭𝐡𝐞 𝟐𝟎𝟐𝟔 𝐓𝐏𝐉 𝐅𝐞𝐥𝐥𝐨𝐰𝐬!
🔬 @martina_legris -Plant development
🧬 @AdamRBentham -Structural biology & AI-driven immune receptor design
🌾 Furong Liu-Engineering disease resistance in crops
📖 Meet our fellows in the editorial 👉 doi.org/10.1111/tpj.71164
🚨 Please share! 🚨
I'm recruiting a fully funded 4-year Gatsby Sainsbury PhD studentship at Durham! 🌱🤖 Designing plant immune receptors from scratch, combining AI protein design with structural biology and plant immunity.
benthamlab.org
shorturl.at/U2PdV
This is very cool and a phenomenal amount of work! Great to see protein design shaping the future of disease resistance bioengineering. We now really have entered the era of truly bespoke resistance!
science.org/doi/10.1126/scie…
Adam Bentham retweeted
Our new preprint is out! Using AI-guided design (RFdiffusion + ProteinMPNN), we engineered a plant immune receptor to recognise non-cognate pathogen effectors.
Huge thanks to our amazing co-authors for making this possible!
doi.org/10.64898/2026.07.10.…
Adam Bentham retweeted
Excited to preprint this collaborative study led by @AdamRBentham in which computationally-designed protein binders were generated that recognise pathogen effectors leading to a plant immune response when deployed within NLR immune receptors.
biorxiv.org/content/10.64898…
Excited to see our new preprint on bioRxiv! 🌱🤖 We used AI protein design (RFdiffusion + ProteinMPNN) to build brand-new sensor domains from scratch and installed them in a rice NLR immune receptor engineering recognition of a Fusarium effector FoSSP17
Our new preprint is out! Using AI-guided design (RFdiffusion + ProteinMPNN), we engineered a plant immune receptor to recognise non-cognate pathogen effectors.
Huge thanks to our amazing co-authors for making this possible!
doi.org/10.64898/2026.07.10.…
Adam Bentham retweeted
📚 𝐅𝐨𝐜𝐮𝐬𝐞𝐝 𝐑𝐞𝐯𝐢𝐞𝐰
"How to frustrate a plant pathogen" 🐛
This review explores new strategies for engineering broad-spectrum resistance against plant pathogen effectors.
✍️ Knight, Heddle, and @adamrbentham
👉 doi.org/10.1111/tpj.70971
Pls RT 🚨I'm looking for someone excited about #proteindesign and #synbio to join my lab @durham_uni and the @CPBM_heddlelab to undertake a PhD using #synthetic knottins as novel #bioinsecticides. If you're interested please get in touch and check out the advert below 👇
With Bluesky now having some nice critical mass I'm no longer going to be actively using Twitter. My account will stay up but the lights are off. Come find me on bluesky if you haven't already!
Adam Bentham retweeted
RhoFold+ is an end-to-end language model-based deep learning approach for predicting 3D structures of RNAs.
nature.com/articles/s41592-0…
Adam Bentham retweeted
A few more letters... and we can finally write amino acid sequence with protein structure encoded by amino acid sequence? 🧬🤔😀
@chrisfrank662 @DominikSchiwie0 Lara Fuss @hendrik_dietz
biorxiv.org/content/10.1101/…
Adam Bentham retweeted
We're happy to present a pre-print from the Hogenhout lab (@SaskiaHogenhout), describing how a family of proteases in aphid oral secretions suppress plant immunity
Aphid effectors suppress plant immunity via recruiting defence proteins to processing bodies biorxiv.org/cgi/content/shor… #biorxiv_plants
Adam Bentham retweeted
Incredibly excited to share new results from Nabla Bio where we show we can design antibodies de novo for use in therapeutic discovery.
We introduce JAM, an AI system we’ve developed to design de novo antibodies with good affinities, early stage developability, and function. We’re seeing success across a range of soluble and hard-to-drug membrane proteins including a Claudin and a GPCR. We’ve extensively tested these designs in our wet lab and included detailed data and controls, providing the first clear demonstration of how de novo design could expand the scope and efficiency of therapeutic antibody discovery. 🧵
Technical report: nabla-public.s3.us-east-1.am…
Blog: nabla.bio/news/denovo
Adam Bentham retweeted
We’re delighted to share our latest preprint from the Hogenhout lab (@SaskiaHogenhout, @JohnInnesCentre) on the molecular mechanisms of plant-aphid interactions. We show how the aphid Mp10 effector protein acts as a local anesthetic, suppressing plant perception of aphid attack.
The conserved aphid saliva chemosensory protein effector Mp10 targets plant AMSH deubiquitinases at cellular membranes to suppress ... biorxiv.org/cgi/content/shor… #biorxiv_plants
Adam Bentham retweeted
So glad to share that it's just published online. 'Conserved effector families render Phytophthora species vulnerable to recognition by NLR receptors in nonhost plants'.
nature.com/articles/s41467-0…
Adam Bentham retweeted
5 days left to apply for the postdoc and research scientist positions in cryo-EM & protein design in our lab! 🔬🦠🧬
They're fully funded for 4 years.
Salary: 42,800 euros gross per year.
See details below:
We're currently looking for new members to join our lab! If you're excited about this research, feel free to reach out!
We already have two open, fully funded positions:
🔬- Postdoc: cnio.es/en/empleo/postdoctor…
🧪- Senior Scientist: cnio.es/en/empleo/research-s…
Adam Bentham retweeted
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.1101/…