AndréassonLab (@AndreassonLab) profile picture

AndréassonLab

@AndreassonLab

We use yeast to understand the molecular mechanisms of cellular protein homeostasis. Account is run by members of the lab.

 Stockholm, Sweden
andreassonlab.com/
Joined January 2021
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  • Following919
  • Followers1.1K
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Photo by AndréassonLab (@AndreassonLab)Photo by AndréassonLab (@AndreassonLab)Photo by AndréassonLab (@AndreassonLab)
From MBoC Genetic inactivation of essential HSF1 reveals an isolated transcriptional stress response selectively induced by protein misfolding Cells counteract stress by inducing adaptive transcriptional programs. Hsf1 in yeast is solely responsible doi.org/10.1091/mbc.E23-05-0…
Image from American Society for Cell Biology (@ASCBiology)
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Latest paper from my former lab- congrats, guys ⁦@AndreassonLab ⁩Protein misfolding releases human Heat Shock Factor 1 (HSF1) from HSP70 latency control sciencedirect.com/science/ar…
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I'm so happy that the first paper from my PhD is finally published🙊. We define the tethers in the yeast vacuole-lipid droplets #membranecontactsite and their role in microlipophagy. Major thanks to all the people that contributed to make this story happen 😁
BüttnerLab (@ButtnerLab) profile pictureBüttnerLab@ButtnerLab14 Feb 2024
We are so proud to share the final version of our latest #MembraneContactSites story🎉, now in @Dev_Cell. We identify the LDO proteins and Vac8 as a tethering pair between the vacuole and lipid droplets (vCLIP) that mediates microlipophagy in starvation cell.com/developmental-cell/…
LDO proteins and Vac8 form a vacuole-lipid droplet contact site to enable starvation-induced...

LDO proteins and Vac8 form a vacuole-lipid droplet contact site to enable starvation-induced...

Álvarez-Guerra et al. identify the tethering machinery of the membrane contact site that enables lipid droplet consumption via lipophagy. They show that nutrient exhaustion drives the formation of...

cell.com
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AndréassonLab retweeted
BüttnerLab (@ButtnerLab) profile picture
BüttnerLab@ButtnerLab14 Feb 2024
We are so proud to share the final version of our latest #MembraneContactSites story🎉, now in @Dev_Cell. We identify the LDO proteins and Vac8 as a tethering pair between the vacuole and lipid droplets (vCLIP) that mediates microlipophagy in starvation cell.com/developmental-cell/…
LDO proteins and Vac8 form a vacuole-lipid droplet contact site to enable starvation-induced...

LDO proteins and Vac8 form a vacuole-lipid droplet contact site to enable starvation-induced...

Álvarez-Guerra et al. identify the tethering machinery of the membrane contact site that enables lipid droplet consumption via lipophagy. They show that nutrient exhaustion drives the formation of...

cell.com
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AndréassonLab retweeted
BüttnerLab (@ButtnerLab) profile picture
BüttnerLab@ButtnerLab12 Jan 2024
We are very proud to share our latest work describing the role of nuclear Hsp104 in protecting the translation machinery during quiescence nature.com/articles/s41467-0…
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Beckmann Lab (@BeckmannLab) profile picture
Beckmann Lab@BeckmannLab30 May 2023
🎉We are thrilled to share our exciting new collaboration with @inada_lab and @jingdongcheng on how Otu2 recognizes and deubiquitinates 40S ribosomes after translation. Here is a thread with the most interesting findings:👇 #ribosome #ubiquitin #cryoEM
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We're happy to share a new paper (the 1st one!) from our SUMO project. A short summary follows. jbc.org/article/S0021-9258(2…
Structural insights into the regulation of the human E2∼SUMO conjugate through analysis of its...

Structural insights into the regulation of the human E2∼SUMO conjugate through analysis of its...

Protein SUMOylation is a ubiquitylation-like post-translational modification (PTM) that is synthesized through an enzymatic cascade involving an E1 (SAE1:SAE2), an E2 (UBC9), and various E3 enzymes....

jbc.org
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Publication alert 🚨In our manuscript, we provide robust methods to biochemically and structurally analyze #mitoribosomes: Yeast Mitoribosome Purification and Analyses by Sucrose Density Centrifugation and Immunoprecipitation pubmed.ncbi.nlm.nih.gov/3716… @Ott_MitoLab #Mitochondria
Yeast Mitoribosome Purification and Analyses by Sucrose Density Centrifugation and Immunoprecipit...

Yeast Mitoribosome Purification and Analyses by Sucrose Density Centrifugation and Immunoprecipit...

Mitochondrial protein biosynthesis is maintained by an interplay between the mitochondrial ribosome (mitoribosome) and a large set of protein interaction partners. This interactome regulates a...

pubmed.ncbi.nlm.nih.gov
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The TIM23 translocase of the inner membrane of mitochondria stabilizes PINK1 and thereby directly influences the distribution of Parkin. Beautiful mechanistic @CellReports study by Toshihiko Oka and Toshiya Endo relevant for mitophagy and parkinson. cell.com/cell-reports/fullte…
Image from Johannes Herrmann (@Herrmann_lab)
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Check out this week's selection of publications on #MembraneContactSites! biomed.news/bims-mecosi/2023… My favourite: doi.org/10.1038/s41556-023-0… Thanks to @Bims_BiomedNews for the pre-selection! #ParkinsonsDisease #Neurodegeneration #MCS #Mitochondria #QualityControl #ESCRT
Image from Verena Kohler (@_VerenaKohler)
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AndréassonLab retweeted
EmSontagMU (@EmSontagMU) profile picture
EmSontagMU@EmSontagMU20 Apr 2023
IT'S FINALLY HERE! A story years in the making about how cells handle misfolded proteins in the nucleus and cytoplasm 1/12 #proteostasis #proteinfolding nature.com/articles/s41556-0…
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Back-to-back JBC papers! Happy to share another JBC paper @jbiolchem on the phase separation of bacterial nucleoid-associated proteins. A great collaboration with my departmental colleague, P. Guptasarma @guptasarma_p & his lab @pglab_iiserm @DBS_IISERM doi.org/10.1016/j.jbc.2023.1…
Image from Samrat Mukhopadhyay (@SamratLabMohali)
Samrat Mukhopadhyay (@SamratLabMohali) profile pictureSamrat Mukhopadhyay@SamratLabMohali21 Apr 2023
Happy to share our 4th paper in the Journal of Biological Chemistry (JBC) @jbiolchem (new role of ATP in yeast prion conversion). Congrats @SayantaIISERM (co-corresponding) @AnushaSarbahi (co-first) @_NehaPunia @AshishJ87810510 @AnamikaAvni @anuja_walimbe doi.org/10.1016/j.jbc.2023.1…
Image from Samrat Mukhopadhyay (@SamratLabMohali)
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The proteomic landscape of genome-wide genetic perturbations cell.com/cell/fulltext/S0092…
The proteomic landscape of genome-wide genetic perturbations

The proteomic landscape of genome-wide genetic perturbations

By combining functional genomics with proteomics, molecular phenotypes in the yeast Saccharomyces cerevisiae can be assigned at genome scale, and systems-level insights reveal principles of how gene...

cell.com
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The phosphorylation status of Hsp82 regulates mitochondrial homeostasis during glucose sensing in Saccharomyces cerevisiae #Proteostasis sciencedirect.com/science/ar…
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Enhanced Degradation of Mutant C9ORF72-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection pubs.acs.org/doi/10.1021/acs…

Enhanced Degradation of Mutant C9ORF72-Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome...

Abstract. A hexanucleotide repeat expansion (HRE) in an intron of gene C9ORF72 is the most common cause of familial amyotrophic lateral sclerosis and front

pubs.acs.org
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Check out this week's selection of publications on #MembraneContactSites! biomed.news/bims-mecosi/2023… Thanks to @Bims_BiomedNews for the pre-selection #MCS #MAMs #EndoplasmicReticulum #Mitochondria #Vacuole #Neurodegeneration #Lipids
Image from Verena Kohler (@_VerenaKohler)
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Check out this week's (small =) ) selection of publications on #MembraneContactSites! biomed.news/bims-mecosi/2022… Thanks to @Bims_BiomedNews for this nice collab! #MAM #MitochondriaAssociatedMembranes #Apoptosis #Lipids
Image from Verena Kohler (@_VerenaKohler)
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Verena Kohler (@_VerenaKohler) profile picture
Verena Kohler@_VerenaKohler8 Nov 2022
Check out this week's selection of publication on #MembraneContactSites: biomed.news/bims-mecosi/2022… Thanks to @Bims_BiomedNews for the pre-selection! #Mitochondria #Autophagy #Seipin #LipidDroplets
Image from Verena Kohler (@_VerenaKohler)
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AndréassonLab retweeted
Verena Kohler (@_VerenaKohler) profile picture
Verena Kohler@_VerenaKohler2 Nov 2022
Check out this week's selection of publications on #MembraneContactSites: biomed.news/bims-mecosi/2022… Thanks to @Bims_BiomedNews for the pre-selection #MAMs #Mitochondria #ER #LipidDroplets #Aging #Calcium
Image from Verena Kohler (@_VerenaKohler)
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Fine-tuning of the Hsc70-based human protein disaggregase machinery by the distinctive C-terminal extension of Apg2 #Proteostasis sciencedirect.com/science/ar…
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