Drew Scott (@AndrewScottPhD) header
Drew Scott (@AndrewScottPhD) profile picture

Drew Scott

@AndrewScottPhD

Brain tumor researcher 🧠 | Neuroscience enthusiast | Tracing metabolic currents and exploring biochemical frontiers, one synaptic spark at a time

 Ann Arbor, MI
Joined June 2019
  • Tweets102
  • Following162
  • Followers207
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Photo by Drew Scott (@AndrewScottPhD)Photo by Drew Scott (@AndrewScottPhD)Photo by Drew Scott (@AndrewScottPhD)Photo by Drew Scott (@AndrewScottPhD)
🧠Food fuels the mind and body, yet brain cancer cells hijack those same nutrients to power their invasive growth. Our @Nature study, using GPS-tracking of nutrients in humans and metabolic flux modeling, reveals how glioblastoma tumors exploit those nutrients for rapid growth. And in preclinical models, depriving tumors of their preferred nutrients slows them down and enhances chemo/radiation! Are precision diets the future of medicine? Thread by @DanWahlMD and full article: nature.com/articles/s41586-0… #BrainCancer #CancerResearch #Metabolism
Image from Drew Scott (@AndrewScottPhD)
Daniel Wahl (@DanWahlMD) profile pictureDaniel Wahl@DanWahlMD4 Sep 2025
New discovery from our team defining how human brain cancers rewire the metabolism of the normal brain published today @Nature and led by @AndrewScottPhD nature.com/articles/s41586-0…
Rewiring of cortical glucose metabolism fuels human brain cancer growth

Rewiring of cortical glucose metabolism fuels human brain cancer growth

Nature - The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative...

nature.com
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Drew Scott retweeted
Defne Bayik (@d_bayik) profile picture
Defne Bayik@d_bayikJun 23
📣Super excited that the first manuscript from our lab @umiamimedicine @SylvesterCancer published today @NatureCancer 🙌 (1/5) nature.com/articles/s43018-0…
GABA signaling activation drives glioblastoma progression in female mice through myeloid-derived...

GABA signaling activation drives glioblastoma progression in female mice through myeloid-derived...

Nature Cancer - Pathak et al. unveil a female vulnerability for glioblastoma according to a mechanism that relies on γ-aminobutyric acid receptor-mediated signaling on granulocytic...

nature.com
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Juyeun Lee (@JuyeunLee31) profile picture
Juyeun Lee@JuyeunLee31May 6
We’re very excited to share our paper just published in @Nature nature.com/articles/s41586-0…
Androgen loss accelerates brain tumour growth via HPA axis activation

Androgen loss accelerates brain tumour growth via HPA axis activation

Nature - Androgens have distinct roles in the brain, acting as immune-based tumour suppressors through neuroinflammation and neuroendocrine mechanisms.

nature.com
Justin Lathia, PhD 🧠🕺🏽 (@JustinLathia) profile pictureJustin Lathia, PhD 🧠🕺🏽@JustinLathiaMay 6
Big news coming later today from @JuyeunLee31 (now with her own lab at @CCFL_BrainTumor ) and our @CCLRI @caseccc lab 🕺
Image from Justin Lathia, PhD 🧠🕺🏽 (@JustinLathia)
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Brain cells refine nitrogen choice with maturity dlvr.it/TSHkl5
Brain cells refine nitrogen choice with maturity

Brain cells refine nitrogen choice with maturity

Nature Metabolism - Nitrogen metabolism is more complex and less mapped than carbon pathways owing to the diversity of nitrogen sources and disjointed routing. Savani et al. develop a multiplexed...

nature.com
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Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice dlvr.it/TSHkdW
Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

Nature Metabolism - This study develops a platform that enables simultaneous, multiplexed tracing of 30 nitrogen isotope-labelled metabolites, uncovering differences in pyrimidine synthesis pathway...

nature.com
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Vennetilab (@vennetilab) profile picture
Vennetilab@vennetilabFeb 4
Super excited to share our recent work on ependymomas spearheaded by the indomitable @shiva251993. nature.com/articles/s41586-0…
ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression

ZFTA–RELA ependymomas make itaconate to epigenetically drive fusion expression

Nature - The ZFTA–RELA fusion, an oncogene for ependymomas, promotes the production of itaconate, and its dependence on this metabolite represents a new therapeutic target for this cancer.

nature.com
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Brain tumor metabolism: the sequel just dropped 🎬 Patients get nutrients. GBM crashes the party, hogs the serine & misuses purines. We built it a digital mirror w/ genetics + isotope tracing. It glimpsed its greed & had an existential crisis. Come watch tumors face the music! #DigitalTwins #BrainCancer #CancerResearch
Cell Metabolism (@Cell_Metabolism) profile pictureCell Metabolism@Cell_Metabolism1 Dec 2025
New! Online now: Digital twins for in vivo metabolic flux estimations in patients with brain cancer dlvr.it/TPZCMM
Image from Cell Metabolism (@Cell_Metabolism)
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Incredibly grateful to colleaguess @BaharanMeghdadi @DNagrathLab @DanWahlMD @LyssiotisLab @Wajd_MD and support from @theNCI and @UMRogelCancer for the opportunity to help bring us closer to making personalized metabolic therapies a reality 🙏
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Excited to share that our digital twin framework predicting patient responses to metabolic therapies is now published online @Cell_Metabolism. One step forward to personalizing glioblastoma treatment. Thankful to my advisors @DNagrathLab @DanWahlMD doi.org/10.1016/j.cmet.2025.…
Image from Baharan Meghdadi (@BaharanMeghdadi)
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Now you serine, now you don't dlvr.it/TNf6sd
Now you serine, now you don't

Now you serine, now you don't

Cancer cells alter metabolic programs to support uncontrolled growth and proliferation. A new study from Scott and colleagues directly examined tumor metabolism in glioblastoma patients and discove...

cell.com
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Thrilled to share our review on cancer GTP metabolism. It unifies structural/biochemical, cell/tumor & clinical perspectives—one of the first maps from molecules to translation. Thanks to co‑authors & Cancer Science! onlinelibrary.wiley.com/doi/…
IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope

IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope

This review provides a systematic summary of the current understanding of IMPDH biology, emphasizing its complex regulation and therapeutic relevance in cancer. We will outline key unresolved...

onlinelibrary.wiley.com
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FROM CELL DEATH TO REGENERATION: What if dying cells -come back to life? Now online @embojournal I tinyurl.com/yp8m7he6 , we aim to answer this question. Here is the journey. If you🩷science, please dont 🛑till the end of 🧵, I promise you will not regret. 1/n
Image from Santosh Chauhan (@Chauhanlab_ILS)
Image from Santosh Chauhan (@Chauhanlab_ILS)
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#NatMetabPicks | In @Nature led by @DanWahlMD @LyssiotisLab @DnagrathLab WN Al-Holou (@UMRogelCancer) Gliomas take up serine from the tumor microenvironment, and can be targeted with dietary serine restriction. nature.com/articles/s41586-0…
Rewiring of cortical glucose metabolism fuels human brain cancer growth

Rewiring of cortical glucose metabolism fuels human brain cancer growth

Nature - The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative...

nature.com
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U-M researchers, including @DanWahlMD, @DNagrathLab, @Wajd_MD, @LyssiotisLab, have found that brain cancer cells rewire how they use sugar, which can be targeted in mice to slow tumor growth and improve treatment responses. Learn more: michmed.org/MD2X2.
Image from Michigan Medicine (@umichmedicine)
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nature (@Nature) profile picture
nature
@Nature4 Sep 2025
Nature research paper: Rewiring of cortical glucose metabolism fuels human brain cancer growth go.nature.com/3UZGoOs
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nature (@Nature) profile picture
nature
@Nature3 Sep 2025
Glioblastoma, an aggressive brain cancer, depends on the amino acid serine as a fuel source go.nature.com/3JJOkkr

Depriving brain tumours of an amino acid could enhance chemotherapy

Nature - Glioblastoma, an aggressive brain cancer, depends on the amino acid serine as a fuel source. A serine-deficient diet has been shown to slow tumour growth in mice.

nature.com
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Grateful for the leadership and support from @DanWahlMD @LyssiotisLab @DNagrathLab @Wajd_MD @UMRogelCancer @UMichRadOnc and @theNCI
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Sidney Ritchie’s life changed with her diagnosis of an aggressive brain cancer. Now she finds meaning and purpose through connection, volunteering, and “showing up fully”. Read how Drs. Al-Holou and @CarlKoschmann helped Sidney navigate her treatment: michmed.org/jV42x.
Image from U-M Rogel Cancer Center (@UMRogelCancer)
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What an excellent meeting. Midwest has the best Metabolism 💪🏼 Thanks to @bensahralab, Nav, & Clara (@NorthwesternMed, @LurieCancer) for hosting. See ya next year in Ann Arbor! @UMich represent 👇🏼〽️ #GoBlue @YatrikShahLab, @DanWahlMD, @DNagrathLab
Image from Lyssiotis Lab (@LyssiotisLab)
Image from Lyssiotis Lab (@LyssiotisLab)
Image from Lyssiotis Lab (@LyssiotisLab)
Image from Lyssiotis Lab (@LyssiotisLab)
Ben-Sahra Lab (@bensahralab) profile pictureBen-Sahra Lab@bensahralab17 Sep 2024
We are excited to host the Midwest Metabolism Meeting (M3) this week! @LurieCancer @NUFeinbergMed. Join us to attend exciting talks and poster presentations by postdocs and students and a keynote address by Prof. Richard DiMarchi @IUBChemistry cancer.northwestern.edu/even…
Midwest Metabolism Meeting (M3)

Midwest Metabolism Meeting (M3)

cancer.northwestern.edu
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New Wahl lab publication! This time led by @erikrpeterson92, truly exceptional Cancer Biology PhD student, comentored by @castro2355_mg . Erik figured out a new way to overcome treatment resistance in the deadly pediatric brain cancer #DIPG. pubmed.ncbi.nlm.nih.gov/3859… (1/n) – at Ann Arbor, MI
Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma - PubMed

Purine salvage promotes treatment resistance in H3K27M-mutant diffuse midline glioma - PubMed

Our results indicate that DMG-H3K27M cells rely on highly active purine synthesis, both from the de novo and salvage synthesis pathways. However, highly active salvage of free purine bases into...

pubmed.ncbi.nlm.nih.gov
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