Andy Hong (@AndyHongMD) profile picture

Andy Hong

@AndyHongMD

#physician #Pediatrics for kids with cancer with a research focus on #cancerresearch #ChildhoodCancer #kidneycancer #RareDiseases

 Atlanta, GA
thehonglab.org/
Joined January 2011
  • Tweets306
  • Following365
  • Followers358
1Media
Photo by Andy Hong (@AndyHongMD)
As we observe #ChildhoodCancerAwarenessMonth, let’s honor the children we’ve lost and recognize the bravery and resilience of those facing cancer. Join me in our fight against childhood cancer and supporting these courageous children and families. #CCAM #ChildhoodCancer
10
14
3
72
9,010
I’m hosting the 12th international pediatric renal tumor biology symposium at MSK in NYC on June 5-7 with @oleg8r and the @COGorg & @WorldSIOP kidney tumor group leads; #Wilms #Rhabdoid #RCC ; Free registration and abstract submission until April 1 here: msk.org/PedsRenalSymposium
1
7
21
1,757
We empower patients with #rarecancers to donate their tissue to research happening at leading institutions + labs through our platform Pattern.org. Some of our partners are @MDAndersonNews, @kochinstitute & @DanaFarber, @broadinstitute, @BrighamWomens, @ATLPedsHemOnc
Image from Rare Cancer Research Foundation + Pattern.org (@RareCancerRF)
4
5
800
Proud mentor moment: getting to see your trainees succeed! Congrats @GarrettC00per with your NCI F31 NOA! @emorygmb @ATLPedsHemOnc
This Post is from a suspended account. Learn more
3
1
1
20
2,051
Out @Nature today! Excited to finally share our work led by Juliann Shih in collab w/ @RameenBeroukhim. Our algorithm “BISCUT” looks at large chromosomal changes and aneuploidy in cancer to detect genes that can account for effects on cellular fitness. nature.com/articles/s41586-0…
22
71
3
277
37,086
What is an exon??? New paper w/ @ewjwallace and @RNA_julie in @CellGenomics : cell.com/cell-genomics/fullt… Cue 🧵1/8
Not all exons are protein coding: Addressing a common misconception

Not all exons are protein coding: Addressing a common misconception

Exons are genomic regions that are transcribed to RNA and retained after introns are spliced out. We clarify the definition of an exon, which is often misused as synonymous to “protein coding.” We...

cell.com
11
301
34
990
165,401
Now online @NatureComms: our study describing an expanded map of genetic dependencies in #chordoma, revealing new potential therapeutic targets (e.g., SHP2). Very special thanks to @SchreiberStuart, Mathias Wawer, and @ChordomaFDN! nature.com/articles/s41467-0…
Mapping the landscape of genetic dependencies in chordoma

Mapping the landscape of genetic dependencies in chordoma

Nature Communications - Cancer cells possess unique molecular features that can confer an increased dependence on specific genes. Here, the authors use CRISPR-Cas9 screens to identify selectively...

nature.com
4
20
4
67
17,450
Andy Hong retweeted
Hao Zhu Lab (@Zhu_Lab) profile picture
Hao Zhu Lab@Zhu_Lab10 Apr 2023
Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: authors.elsevier.com/a/1gua9… 1/10
37
182
25
652
194,115
Paper alert! 🚨 Studying the mSWI/SNF chromatin remodeling complex, by single and combinatorial Perturb-seq and SHARE-seq! Incredibly fun joint work with Jordan Otto Jagielski (her PhD thesis!) and @alexpywu, collab between Regev and @CKadoch labs! 1/n cell.com/molecular-cell/full…
Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through...

Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through...

Otto et al. use Perturb-seq-based single-cell profiling to reveal that chromatin accessibility and gene expression are driven by unique subunits, modules, and subassemblies within the heterogeneous...

cell.com
2
27
1
113
15,517
H3K27ac has been the go-to hallmark of enhancers for over a decade, but what if another chromatin feature exceeds this in predicting enhancers? Our paper was just published @NatureGenet rdcu.be/c9tUg Congrats to @TakeoNarita80, Yoshiki and the rest of the team.
14
134
10
509
104,769
Sharing this in case it's useful: I find that students often have a hard time conceptualizing quantitative parameters in genomics and popgen Here's a cheat-sheet I put together for teaching. It's also part of a textbook I have been writing on human genetics (more on that below)
Image from Jonathan Pritchard (@jkpritch)
24
437
31
1,553
209,487
It's finally here!! Our Method of the Year 2022 is....long-read sequencing! 🎉 Read our (free!) Editorial to learn why we felt the time was right to select this class of powerful technologies as the Method of the Year. nature.com/articles/s41592-0…
Image from Nature Methods (@naturemethods)
17
489
71
787
237,622
The field of chromatin biology lost a giant with the passing of David Allis. His science achievements & mentoring record are both stunning. He had a remarkable ability to make personal connections & mentor; he shared some insights into his approach here: pnas.org/doi/full/10.1073/pn…

On being an advisor to today’s junior scientists | PNAS

On being an advisor to today’s junior scientists

pnas.org
8
51
6
255
59,274
At the end of a great @GeneticsSociety #ASHG22, I wanted to share & get feedback on my "cheatsheet" of online resources, tools, and databases. This was developed with @capra_lab collabs 🙏and at VUMC medical genetics. Please comment/message to add 💡! docs.google.com/document/d/1…
Image from Evonne McArthur (@EvonneMcArthur)
15
126
13
437
We're doing a thing! Speakers @HHMINEWS Science Meetings will no longer put journal names on their talk slides. Instead display first author, year, PMID (or DOI) like @ardemp Why? -end prestige-signaling -people can actually find reference #nojournalnamesontalkslides
Image from Leslie Vosshall PhD (@leslievosshall)
91
296
159
1,976
Dr. Audrey Evans, a pediatric oncologist who helped create the first Ronald McDonald House, a concept that has blossomed into a worldwide network, has died at 97. nyti.ms/3LWFZXG
Dr. Audrey Evans, Cancer Specialist Who Gave Families a Home, Dies at 97 (Published 2022)

Dr. Audrey Evans, Cancer Specialist Who Gave Families a Home, Dies at 97 (Published 2022)

She was a prominent figure in the field of childhood cancer when, in 1974, she helped create the first Ronald McDonald House in Philadelphia.

nytimes.com
31
289
37
1,721
Out in @Nature today, we report that #p53 loss unleashes an ordered & selective pattern of cancer #GenomeEvolution: nature.com/articles/s41586-0…. 1/n
Ordered and deterministic cancer genome evolution after p53 loss

Ordered and deterministic cancer genome evolution after p53 loss

Nature - Malignant evolution enabled by p53 inactivation in mice proceeds through an ordered and predictable pattern of Trp53 loss of heterozygosity, accumulation of deletions, genome doubling and...

nature.com
10
207
16
829
🛑KEY POINT, READ THIS🛑 If you are dealing with collections of data, particularly those that span a long period of time, differences in processing like this WILL confound your results. You MUST make sure the data is uniformly processed or your results will likely be invalid. 13/
1
4
2
36
Excited to share our new work on FOXR2 as an epigenetically activated pan-cancer oncogene in @AACR Cancer Research - a wonderful collaboration between @Bando_Lab, the Phoenix Lab, and @dtwjones
This Post is from an account that no longer exists. Learn more
4
3
3
29
Load more