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Andy Puig

@AndyPuig
Joined October 2009
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Photo by Andy Puig (@AndyPuig)Photo by Andy Puig (@AndyPuig)Photo by Andy Puig (@AndyPuig)Photo by Andy Puig (@AndyPuig)Photo by Andy Puig (@AndyPuig)Photo by Andy Puig (@AndyPuig)Photo by Andy Puig (@AndyPuig)Photo by Andy Puig (@AndyPuig)Photo by Andy Puig (@AndyPuig)Photo by Andy Puig (@AndyPuig)
Paper alert!! So happy to see this findings out from the lab 🤗Congratulations @kari_jacome and all other authors!! Chromatin accessibility classification of TAD boundaries discloses new architectural proteins biorxiv.org/content/10.1101/…
Chromatin accessibility classification of TAD boundaries discloses new architectural proteins

Chromatin accessibility classification of TAD boundaries discloses new architectural proteins

3D genome organization is crucial to modulate gene expression. Topologically Associated Domains (TADs) isolate genes and their regulatory elements within the same topological neighborhood, avoiding...

biorxiv.org
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Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? biorxiv.org/content/10.1101/…
Image from Sofi Quinodoz (@sofiquinodoz)
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I am so excited to share this part of my PhD where we tackle the question: What impact do 3D contacts have on how enhancers regulate their target genes? biorxiv.org/content/10.1101/… 1/
Image from Philine (@PGuckelberger)
Image from Philine (@PGuckelberger)
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Check this out 👇👇 ! :)
Akis Papantonis (@AkisPapantonis) profile pictureAkis Papantonis@AkisPapantonis17 Jul 2024
New preprint from the lab just dropped! Led by former PhD student @palikyras, our work explains how cells exploit the changed biochemistry of their nuclei to cluster CTCF on nuclear speckles and commit to the fate of senescence. A long(ish) thread... biorxiv.org/content/10.1101/…
Senescent cells cluster CTCF on nuclear speckles to sustain their splicing program

Senescent cells cluster CTCF on nuclear speckles to sustain their splicing program

Senescence —the endpoint of replicative lifespan for normal cells— is established via a complex sequence of molecular events. One such event is the dramatic reorganization of CTCF into senescence-i...

biorxiv.org
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END-OF-THE-YEAR-PREPRINT 🎄 We took a deep dive into the characteristics and dynamics of DNA loop extrusion by the eukaryotic SMC complexes – with some unexpected findings. Get comfy with your Glühwein and have a read... Thread below /1 📜Manuscript: t.ly/uFuPK
Image from Roman Barth (@RomanBarth2)
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Están todes invitades :)
Fisiología Celular UNAM (@IFC_UNAM) profile pictureFisiología Celular UNAM@IFC_UNAM6 Dec 2023
Image from Fisiología Celular UNAM (@IFC_UNAM)
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Perrito descubre su reflejo 🥰
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Gran oportunidad para estudiar y entender el envejecimiento del cerebro en México. @PerlaMorCas @cinvestav
Image from Luis B Tovar-y-Romo (@TyR_lab)
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Check out the amazing work of my dearest mentor and friend: @nirvalite; Felicidades amiga! 👏 👏
Fisiología Celular UNAM (@IFC_UNAM) profile pictureFisiología Celular UNAM@IFC_UNAM8 Aug 2023
Nueva publicación IFC 🤓👇🏼 rdcu.be/dhZS9 #OrgulloIFC #ciencia #UNAM
Image from Fisiología Celular UNAM (@IFC_UNAM)
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So glad to see my PhD work, under the great mentorship of @FurlanLab, now published! We characterized the genome organization of nucleated chicken erythrocytes in relation with the severe transcriptional repression that takes place during terminal erythropoiesis 🩸. 1/5
Furlan-Magaril_lab (@FurlanLab) profile pictureFurlan-Magaril_lab@FurlanLab27 Jul 2023
Paper alert! 🐣🐣❤️So happy to see this published @NatureSMB. Congratulations to Andrés, @AndyPuig, Sherlyn @SherlynClaudio and all authors. Well done Andrés! @IFC_UNAM. Thanks to @sarakosman, @DimitrisTypas and reviewers. nature.com/articles/s41594-0…
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Our work adds to current discussions on the role of the paused RNA Pol II promoting local organization and opens interesting questions about gene expression and the control of the RNA Pol II activity in erythrocytes. 4/5
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This would not have been possible without the contributions of the superb @SherlynClaudio and everyone at @FurlanLab’s group at the @IFC_UNAM . You can read more about this thrilling story here: rdcu.be/dhUmY 5/5
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Our latest paper - now published in its final form @NatureGenet - examines long-standing questions about enhancer-promoter communication. nature.com/articles/s41588-0… A brief thread with the key results is below.
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