Postdoc @ University of Melbourne/Peter Mac | cancer biology x cell cycle x epigenetics x CDK2/4/6i
Melbourne, Victoria
Joined March 2014
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April Watt retweeted
A nice follow-up to our recent @Nature paper (@BarbMarte).
Nature has published a News & Views piece discussing the work: “The secret life of a cell-cycle gatekeeper of cancer.”
Very proud of the team. Interested to hear where these concepts go next.
nature.com/articles/d41586-0…
April Watt retweeted
Delighted to share our new paper, published today in @Nature , led by @AprilCWatt and @AntonioAhnNZ at the @PeterMacCC and The University of Melbourne @uommedia
Paper: nature.com/articles/s41586-0…
Excited to share our work, now in @Nature! Delighted to have co-led this study with co-first author @AntonioAhnNZ under the supervision of @shomgoel at @PeterMacCC @PeterMacRes and the University of Melbourne @uommedia
Open access:
nature.com/articles/s41586-0…
April Watt retweeted
Peter Mac researchers from @shomgoel's lab have uncovered why breast cancer treatment stops working for some patients.
Published in @Nature, the discovery could help develop new treatment combinations that work for longer and improve outcomes.
More: petermac.org/about-us/news-a…
April Watt retweeted
Congratulations @AprilCWatt on a great talk at @SABCSSanAntonio. Provided the first real explanation of why CDK4/6 inhibitors and endocrine therapy work together, with major implications for understanding resistance and therapy development.
April Watt retweeted
Congratulations @AprilCWatt on a great talk at @SABCSSanAntonio. Provided the first real explanation of why CDK4/6 inhibitors and endocrine therapy work together, with major implications for understanding resistance and therapy development.
April Watt retweeted
Happy to share our new study describing the effects of CDK2 inhibition in solid cancers. It has been a fun and stimulating collaboration with @incyclixbio and fantastic to work with INX-315, their selective and potent CDK2 inhibitor.
doi.org/10.1158/2159-8290.CD……
April Watt retweeted
‘How is your PhD going?’ nitter.cf/buitengebieden/status/…
April Watt retweeted
Can we expand the potential of existing cancer therapies through strategic drug schedules & combinations? Read our perspective on harnessing the immunotherapeutic activity of CDK4/6 inhibitors for combo therapies
nature.com/articles/s41698-0… @PeterMacRes @Nature_NPJ #precisiononcology
April Watt retweeted
Here's our perspective on targeting CDK4/6, just published in Nature Reviews Cancer @NatureRevCancer @PeterMacRes @UniMelbMDHS @SnowMedical. CDK4/6i's have transformed breast cancer therapy, but we have still only realised a fraction of their potential! rdcu.be/cJhFx
Check out our latest review on CDK4/6i in HR+ #breastcancer, published with @SpringerNature in @BCRJournal. We cover research on mechanisms of action beyond cytostasis, summarize current knowledge on acquired resistance, and more… @shomgoel rdcu.be/cIkE0
Congratulations @shomgoel ! Looking forward to all the exciting research the team will be able to embark on
Thank you to @SnowMedical and the visionary Snow family for this once-in-a-lifetime opportunity. I am honoured to be named a Snow Fellow and know that this will be life changing for me and my team. Congratulations also to @meleckmas and @DrMarinaPajic!
April Watt retweeted
Enhancer redundancy in development and disease go.nature.com/2KhuvTq #Review by @evgenykvon, @WayMaxxed, Mario G. Elabd & @zebabw
April Watt retweeted
Many thanks to Antoni Hurtado for the detailed and insightful discussion of our lab's recent research. @NatureCancer @krknrm @UniBarcelona @PeterMacRes nature.com/articles/s43018-0…
April Watt retweeted
The epigenetic basis of cellular heterogeneity go.nature.com/37g8Hir #Review by Benjamin Carter & Keji Zhao
April Watt retweeted
I couldn’t just walk past this Tweet, so here is some fun #dataviz
Scented candles: An unexpected victim of the COVID-19 pandemic 1/n
ALT 3 R-generated graphs: 1) Top 3 unscented candles 2017-2020 reviews: rating (1-5) on the y axis; date on the x axis; the scatterplot shows a relatively flat line across the three years. N = 1,118 2) Top 3 scented candles 2017-2020 reviews: rating (1-5) on the y axis; date on the x axis; the scatterplot shows a relatively flat line that drops off sharply after January 2020. N = 11,404 3) A bar chart with 11 bars (January-November 2020). Proportion of reviews mentioning lack of scent on the y axis; month on the x axis. January = 2%, February = 3.5%, March = 2.8%, April = 4.6%, May = 3.4%, June = 2.4%, July = 3%, August = 3.2%, September = 3.1%, October = 5.8%, November = 5.8%.
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April Watt retweeted
Need a read for the weekend? #SpecialIssue on Methods: #scRNAseq of human milk-derived cells, a novel & non-invasive framework for investigating physiology of human #lactation by @JMartinCarli & @MikeRudolph20.
link.springer.com/article/10…
April Watt retweeted
Opposing Effects of Cohesin and Transcription on CTCF Organization Revealed by Super-resolution Imaging dlvr.it/Rm4tR0
April Watt retweeted
In #breastcancer, CDK4/6i stimulates AP-1 to activate classical super-enhancers that drive luminal differentiation & apoptotic evasion, as well as enhancers overlying endogenous retroviral elements that are enriched for proximity to IFN-driven genes: nature.com/articles/s43018-0…
Pleased to share our work on the epigenetic effects of CDK4/6 inhibition in breast cancer @NatureCancer. A fruitful collaboration between the @shomgoel Lab at @PeterMacCC @PeterMacRes and our colleagues @CFCE_DanaFarber @DanaFarber. Thread below.
nature.com/articles/s43018-0…
Many, many thanks to my co-first authors @palocejas and Molly DeCristo, as well as Henry Long. This work was only possible bc of your dedication and teamwork.
Thank you @MAFD110, @enidylam, @gilan_omer, @charles_bell92 for your work on this project and helping me find my footing at Peter Mac. Finally, thank you @shomgoel for everything esp your excellent leadership on this project.