@AranyLab

We are the Arany lab at University of Pennsylvania. We love metabolism !

 University of Pennsylvania
med.upenn.edu/aranylab/
Joined December 2019
  • Tweets237
  • Following186
  • Followers1.4K
33Media
New! Online now: Quantification of nutrient fluxes during acute exercise in mice dlvr.it/TFMr8Y
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Reporting with pride: (1) our star Jessie Axsom is now Dr.! (2) her paper is out @Cell_Metabolism: unbelievably comprehensive quantification of fuel fluxes in #exercise mice - lots of surprises. #MoTrPAC: take note. w/Rabinowitz lab. Free link 50days: authors.elsevier.com/a/1jxL7…
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Fantastic brief historical overview of mechanism behind #preeclampsia from brilliant friend @ananthmsn34 in @jclinicalinvest : jci.org/articles/view/184052…
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The Arany lab retweeted
Cell@CellCellPress
1 Aug 2024
From our newest anniversary focus issue on #Metabolism! "Human cardiac metabolism" @AranyLab @PennMedicine & colleagues Read the review: cell.com/cell-metabolism/abs… #50YearsofCell
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We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! biorxiv.org/content/10.1101/…

SGLT2 inhibitors activate pantothenate kinase in the human heart

Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and mortality benefits in the treatment of heart failure but appear to do so independently of SGLT2. The relevant...

biorxiv.org
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it's been a while since we posted... Here our recent review w/ @Rongtian2 on HUMAN cardiac metabolism in @Cell_Metabolism : deep dive going back 50+yrs - turned out to be >300 refs! Much is known, much MORE needs figured out... cell.com/cell-metabolism/pdf…
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The Arany lab retweeted
PennCVI@PennCVI
25 Jul 2024
CVI's Highlighted #PapersoftheWeek pubmed.ncbi.nlm.nih.gov/3904…
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Translating metabolic and cardiovascular research into effective treatments: What’s next? Some thoughts from several of us on the topic, in this issue of Cell: authors.elsevier.com/a/1jUX4… @JuleenRZierath @JolandavanderV4 @Alicardsdoc @rosenzweig_a @DebMuoio
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The Arany lab retweeted
Boa Kim
@BoaKim5
6 May 2024
I am pleased to share a preprint ‘HIF2α-dependent inhibition of mitochondrial clustering of glutaminase suppresses clear cell renal cell carcinoma’. biorxiv.org/content/10.1101/…

HIF2α-dependent inhibition of mitochondrial clustering of glutaminase suppresses clear cell renal...

Clear cell renal cell carcinomas (ccRCC) are largely driven by HIF2α and are avid consumers of glutamine. However, inhibitors of glutaminase1 (GLS1), the first step in glutaminolysis, have not shown...

biorxiv.org
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A few days late:  Congratulations to Daniel @daniel_baker_j for winning the 2024 @Phacilitate Young Scientist Award from Advanced Therapies Awards — including Glittering Gala dinner in Miami !
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New manuscript from our group studying DCM-TTNtvs and transcriptional modulators that reverse haploinsufficiency. ahajournals.org/doi/10.1161/…

CRISPR Activation Reverses Haploinsufficiency and Functional Deficits Caused by TTN Truncation...

BACKGROUND: TTN truncation variants (TTNtvs) are the most common genetic lesion identified in individuals with dilated cardiomyopathy, a disease with high morbidity and mortality rates. TTNtvs reduce...

ahajournals.org
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The Arany lab retweeted
Ben Prosser@Prosser_Lab
17 Jan 2024
Interested in TTN/DCM? Check out current edition of @jclinicalinvest. 2 new reports: 1 by us w/ @Arany Lab and 1 from Miklos Kellermayer, plus commentary by @TravisHinson and Stuart Campbell. We know a lot more about TTN pathomechanisms! ...and we know what we don't know. 🧵1/4
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14 key points from our recent review on peripartum cardiomyopathy #PPCM in @NEJM , summarized in @ACCinTouch , thank you @MelindaDavisMD. acc.org/Latest-in-Cardiology…
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The Arany lab retweeted
NEJM
@NEJM
13 Jan 2024
Review Article by Zoltan Arany, M.D., Ph.D. (@AranyLab): Peripartum Cardiomyopathy nej.md/48pUCx3 #Cardiology

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Our latest review on peripartum cardiomyopathy #PPCM in @NEJM this week -- review of mechanism, genetics, clinical management, epi and prognosis -- lots of unknowns, huge racial disparities. Hope you enjoy it! nejm.org/doi/full/10.1056/NE…

Peripartum Cardiomyopathy | NEJM

The author discusses the epidemiology and clinical presentation of peripartum cardiomyopathy, as well as the mechanistic basis for potential therapeutics.

nejm.org
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High fat consumption & blood pressure elevation ft. @BoaKim5, @WencaoZhao, Soon Tang, @MGLevin, @_AyonIbrahim, Yifan Yang, Ling Lai, Jian Li, @FitzGerald__Lab, @AranyLab (@PennCVI/ @PennIDOM) Emilia Roberts & Richard Assoian (@PennSysPharmATT) tinyurl.com/35b3tfm5
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Cool:  Lauren has just been selected to serve as the intern on the American Society of Nephrology Policy and Advocacy committee for Jan-Dec 2024 !  First non-postdoc/fellow that they’ve accepted, apparently! Congratulations !! @metabolauren @ASNKidney
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Deadlines are approaching for @KeystoneSymp #Cardiometabolic Diseases: #EthnicDiversity in #PrecisionMedicine, this February in Vancouver! See scholarship, abstract and discount reg dates: keysym.us/KSCardiometab24 #KSCardiometab24 #Cardiovascular nitter.cf/realbarryyyy/status/16…
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The Arany lab retweeted
PennCVI@PennCVI
5 Dec 2023
CVI is accepting applications for AHA Summer Undergraduate Fellowships! Students who are underrepresented in medicine encouraged to apply. Application deadline is Feb 14, 2024. med.upenn.edu/cvi/american-h… #undergraduatefellowships #cardiologyresearch
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A tremendous joint meeting @StanfordCVI / @PennCVI /Duke /@WCM_CVRI hosted by Stanford - inspiring keynote by @nih_nhlbi director Gary Gibbons, amazing science all around, and lots of friends. Thank you @Joseph_C_Wu for hosting! @saptarsi_haldar @tcappola1 @Sharlen40950143
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