GS4 MD/PhD in Reynolds Lab @ UTSW. Previously: IRTA fellow Rotman Lab @ NIH ‘18 | BS @ Cornell University ‘16 - statements here are my own
Dallas, TX
Joined September 2014
- Tweets114
- Following170
- Followers109
- Likes1.4K
Philip Brown retweeted
@kimreynolds_lab based @UTSWMedCenter show that biochemical coupling between metabolic enzymes shapes the range of enzyme activities sufficient to rescue cell growth
nature.com/articles/s41467-0…
Philip Brown retweeted
A long-acting #LEAP2 agonist as a new treatment for #MAFLD #fattyliver and #obesity ? @oceankripa and the rest of the @ZigmanLab say YES! #ghrelin
authors.elsevier.com/sd/arti…
preprint now available @MolMetab
@UTSWMedCenter @UTSWInternalMed @UTSWBrain @UTSWdiabetes
Philip Brown retweeted
Physical protein interactions constrain interface sequence. But what about non-binding "biochemical" interactions in metabolism? We used deep mutational scanning to map sequence constraints for two enzymes that catalyze consecutive metabolic reactions: rdcu.be/dE7xl
Philip Brown retweeted
The “ORBIT for E. coli” paper is out in Nucleic Acids Research! doi.org/10.1093/nar/gkae227
**Perform genetics (e.g. deletions) without any PCR / cloning – just transform an oligo!**
The paper demonstrates benefits over λ Red & shows how oligos scale to high throughput libraries.
ALT Electroporation of a an oligo and non replicating plasmid can be used to make a gene deletion in E. coli.
Philip Brown retweeted
Our @NIDDKgov lab is seeking a #postdoc for exciting project assessing how human #liver in #MASLD handles fasted-to-fed transition.
Unicorns comfortable with bioinformatics, molecular biology and physiology should apply.
Details 👇
Friends please RT!
niddk.nih.gov/research-fundi…
Proud to share our recently published work from @kimreynolds_lab! Ever wanted to quantify epistatic relationships between genes? Here’s our proposed model in E. Coli!
A continuous epistasis model: Cell Systems cell.com/cell-systems/fullte…
#UTSW #genetics #systemsbiology #mstp
Philip Brown retweeted
Goood (late) morning! This is Phil Brown (@B3Phil) here - long time metabolism fan, and current student in the Molecular Metabolism & Metabolic Disease Track! I’m at the controls of the UTSW3MD Twitter (X?) account today - so I’ll share about myself and a day in the life of 3MD!
Philip Brown retweeted
Mitochondrial fatty acid synthesis is an emergent central regulator of mammalian oxidative metabolism dlvr.it/T0ySTw
Philip Brown retweeted
Our 1st preprint!
We developed a genetic toolkit for E. coli that directly uses cheap DNA oligos to specify kb scale mutations. No PCR/cloning to delete genes!
The paper demonstrates benefits over λ Red & gets fancy w/ pooled mutant libraries. 1/15
biorxiv.org/content/10.1101/…
Philip Brown retweeted
I always carb load before bioinformatics.
ALT Picture of a tote bag that says, “eat pasta run fasta”
Philip Brown retweeted
Congratulations to @ginajpark on receiving the 2023 Ida M. Green Award! In her dissertation research, Gina discovered the mechanism of mRNA capping by SARS-CoV-2, involving a novel reaction catalyzed by a pseudokinase domain. Congratulations, Gina!
Philip Brown retweeted
We are so proud of @VancityReynolds ...well not that Ryan Reynolds, but our Ryan Reynolds on his PhD thesis defense today.
Philip Brown retweeted
#MetabolismMasterclass today at 4PM
Today's speaker is Dr. Joachim Herz.
"Preventing Alzheimer’s – Novel Mechanisms and Therapeutic Approaches"
@UTSWGradSchool @UTSWmstp @UTSW_NeuroGrads @UTSWNeurosci @UTSWNeurology
Philip Brown retweeted
#Metabolize with us on Thu 3/9 5pm at "Bottles & BS".
Organized by @UTSW3MD's Social Committee.
Faculty Guest Dr. Markey McNutt.
Food is on us!
@UTSW3MD @UTSWGradSchool @GDDgradprogUTSW @UTSWmstp @UTSW_NeuroGrads @UTSWCancerBio students are invited.
Philip Brown retweeted
@UTSWGradSchool @GDDgradprogUTSW @UTSWmstp @UTSW_NeuroGrads @UTSWCancerBio @CmbUtsw students this is for you. "Bottles & BS". Brought to you Thursday 2/16 6pm. Hosted by @UTSW3MD's Social Committee with @B3Phil. See you there!! #metabolize with us at @on_rotation. Food is on us.
Philip Brown retweeted
Cornell is increasing grad stipends to $43k for next year, requiring summer funding to be provided for all PhD students, cutting grad tuition costs for private Cornell colleges cause they are currently higher than the public ones
Philip Brown retweeted
I recently learned that my tenure application was approved!! So grateful to all the fantastic students, fellows, and staff that I've had the privilege of working with. What a great lab team. And excited for what comes next! @MolBiophysUTSW @LHBioinf_UTSW @UTSWcomps
Philip Brown retweeted
RESEARCH | Led by Jian Xu (@UTSWNews):
The authors provide insight into the regulation of branched-chain amino acid #metabolism and its impact on whole-body physiology by identifying and characterizing a metabolon formation.
nature.com/articles/s42255-0…
Philip Brown retweeted
@B3Phil may be a @GDDgradprogUTSW student, but @UTSW3MD is claiming him, too! Come check out Phil's presentation (and Ping Mu's presentation) at GDD WIPs today at noon in NA6.212.
