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Baum Lab SLU

@BaumLabSLU

Twitter account for the Baum Lab in the Department of Chemistry at Saint Louis University

 St. Louis, MO, USA
danabaumlab.com
Joined August 2014
  • Tweets659
  • Following222
  • Followers275
131Media
Photo by Baum Lab SLU (@BaumLabSLU)Photo by Baum Lab SLU (@BaumLabSLU)Photo by Baum Lab SLU (@BaumLabSLU)Photo by Baum Lab SLU (@BaumLabSLU)Photo by Baum Lab SLU (@BaumLabSLU)Photo by Baum Lab SLU (@BaumLabSLU)Photo by Baum Lab SLU (@BaumLabSLU)Photo by Baum Lab SLU (@BaumLabSLU)Photo by Baum Lab SLU (@BaumLabSLU)Photo by Baum Lab SLU (@BaumLabSLU)
Replying to @BaumLabSLU
@BaumLabSLU and Piotr Mak have identified key axial ligands in the heme-guanine quadruplex complex. Understanding function of non-canonical DNA structures such as G4 will inform rational design of biocatalysts, biosensors, and new drug targets. Read more doi.org/10.1016/j.jinorgbio.…
Guanine quadruplexes are non-canonical DNA structures that can bind heme prosthetic group, resulting in heme-bound G-quadruplexes (heme-G4) that exhibit enhanced peroxidase activity and act as promising biocatalysts. Electronic absorption and resonance Raman spectroscopic studies demonstrate that the oxygen atom of the guanine base acts as a heme axial ligand.

ALT Guanine quadruplexes are non-canonical DNA structures that can bind heme prosthetic group, resulting in heme-bound G-quadruplexes (heme-G4) that exhibit enhanced peroxidase activity and act as promising biocatalysts. Electronic absorption and resonance Raman spectroscopic studies demonstrate that the oxygen atom of the guanine base acts as a heme axial ligand.

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🚨 Calling Alumni 🚨 Get the latest news of all things SSE! Join SLU's School of Science and Engineering Dean Gregory Triplett, Ph.D., for a Virtual Town Hall from 6-7 p.m. CT on Thursday, September 12. Register now: loom.ly/YArBEMs
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Baum Lab SLU retweeted
SLU Research (@SLUResearch) profile picture
SLU Research@SLUResearch5 Dec 2023
Excited for the Bio-Chem Research Symposium 2023 on Dec 9 at @SLU_Official. Great research presented by #SLU faculty and a keynote from @UCIrvine's Krzysztof Palczewski, the scientist who crystallized the first G Protein Coupled Receptor. Do not miss! biochem.slu.edu/event/bio-ch…
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Our final Cover Feature on Issue 1 is the work of John S. Samuelian and Dana A. Baum (@BaumLabSLU @SLUChemDept @SLUResearch) on identification of DNA aptamers for benzodiazepine detection in synthetic urine chemistry-europe.onlinelibra…
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Baum Lab SLU retweeted
PCE3 (@PCE3_Sci) profile picture
PCE3@PCE3_Sci13 Sep 2022
More news from @BurkeLabRNA, recipient of one of the 2020 NASA ICAR grants. RNA molecules shifting cofactors reduction potential 🙀Congratulations!!👏 nature.com/articles/s41589-0…
BurkeLab (@BurkeLabRNA) profile pictureBurkeLab@BurkeLabRNA12 Sep 2022
Parade of Big Papers continues! Last week @SkylerTKramer1 @BiochemPhD and @BurkeLabRNA put out the FASTAptameR 2.0 toolkit. sciencedirect.com/science/ar… TODAY we have a exciting new story in @nchembio revealing surprising consequences of RNA interactions with nucleotide cofactors.
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Sad to learn that #Yale Prof. and colleague #SidneyAltman, 1989 Chemistry #Nobel recipient, has died. His publication on the #ribozyme action of #RNaseP was a milestone discovery in the now exploding field of #ncRNA. The photo shows him celebrating the news of his Nobel Prize.
Image from Ronald Breaker (@RonBreaker)
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See how the ribozyme catalyzes RNA methylation! @Caro_Scheitl @Uni_WUE in @nchembio rdcu.be/cJcte The mechanism involves acid catalysis and a protonated nucleobase in the cofactor binding site. Ribose modification in the active site accelerates the ribozyme.
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Baum Lab SLU retweeted
Yingfu Li (@Yingfu8888) profile picture
Yingfu Li@Yingfu888825 Jan 2022
AddThis | Home authors.elsevier.com/a/1eTdz… Wanted to write this review for a long time, and finally got the time to do it during COVID-19 pandemic. I hope it is a step stone for encouraging more thoughts on how to make better aptamers for more real-world applications!
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Baum Lab SLU retweeted
nature (@Nature) profile picture
nature
@Nature24 Dec 2021
Nature research paper: Time-resolved structural analysis of an RNA-cleaving DNA catalyst nature.com/articles/s41586-0…
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In a message to the SLU community today, University Provost Michael Lewis, Ph.D., announced the final plans for a reimagined College of Arts and Sciences and the establishment of a new School of Science and Engineering. Learn more: loom.ly/gtyAKXI
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#OTD in 1982, Science News reported that Thomas Cech and colleagues have found that RNA can function like an enzyme to trigger the synthesis of proteins —  the discovery of ribozymes. #SN100 sciencenews.org/archive/rna-…
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DNA in movies vs. real DNA
Image from DNA&RNA Universe 𝕏 (@DNA_RNA_Uni)
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Tomorrow is about connecting as #OneSLU. Find an event. Share with a friend. Explore a resource. ow.ly/4spg50GfE0x See you there, Billiken family.
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CAPTCHA
Image from DNA&RNA Universe 𝕏 (@DNA_RNA_Uni)
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PCR Troubleshooting Bingo 👌 #sciencetwitter #phdchat #DNA #RNA #PCR #troubleshooting @grawoig @PeptideScience @CarDrevy @_atanas_ @nanopore 𝕒𝕕𝕧𝕖𝕣𝕥𝕚𝕤𝕖𝕞𝕖𝕟𝕥: check also mdpi.com/1422-0067/22/14/738…
Image from DNA&RNA Universe 𝕏 (@DNA_RNA_Uni)
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"Using RNA to increase Flavin Redox Potential" por Donald Burke @BurkeLabRNA 👉youtu.be/YCLqc1EMDG8 @DrMoeyG
Image from ASTROBIOLOGÍA (@IAstrobiologia)
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Baum Lab SLU retweeted
Chem Soc Rev (@ChemSocRev) profile picture
Chem Soc Rev@ChemSocRev12 Nov 2020
Check out our themed collection on Nucleic Acids 😄It includes Review Articles like 'Covalent labeling of nucleic acids' by Andrea Rentmeister #openaccess 🔓 Read here: xlink.rsc.org/?doi=D0CS00600… rsc.li/nucleic-acids
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Aptamers. You think you know what they do? Well, think again! pubs.acs.org/doi/10.1021/jac… Great collaboration with Belgian colleagues and my PhD student Elise Daems (twitterless)
Do Aptamers Always Bind? The Need for a Multifaceted Analytical Approach When Demonstrating Binding...

Do Aptamers Always Bind? The Need for a Multifaceted Analytical Approach When Demonstrating Binding...

Abstract. In this manuscript, we compare different analytical methodologies to validate or disprove the binding capabilities of aptamer sequences. This was

pubs.acs.org
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Saint Louis University’s STEM programs have launched a crowdfunding campaign to raise funds for STEM@SLU, a new University initiative designed to increase the stature of the science, technology, engineering and math disciplines at SLU: ow.ly/52uF50Ch9It
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Replying to @batterybriefs
@Energystorage4 @ECSorg – at Thanjavur, India
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