Bhandoola_Lab (@Bhandoola_Lab) profile picture

Bhandoola_Lab

@Bhandoola_Lab

As a lab, we're all in.

Joined February 2024
  • Tweets21
  • Following43
  • Followers25
Arundhoti Das' review on ILC development was published, shortly after she started her own lab. Yi Ding and Christelle Harly are co-authors. nature.com/articles/s41590-0…
The development of innate lymphoid cells

The development of innate lymphoid cells

Nature Immunology - In this Review, Bhandoola et al. discuss recent advances in understanding early developmental stages of innate lymphoid cells originating from lymphoid progenitors in mice.

nature.com
1
3
59
cell.com/immunity/abstract/S… NFIL3 resides at the apex - as far as I know, at least - of a transcription factor hierarchy that initiates innate lymphoid specification.
The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors

The transcription factor NFIL3 drives innate lymphoid cell specification from lymphoid progenitors

Understanding the mechanisms underlying innate lymphoid cell (ILC) specification may provide insight into ILC functions in immunity and tissue homeostasis. Léger et al. demonstrate that NFIL3...

cell.com
2
5
359
Much to add. Two long obsessions, finally published last year. First, this one: journals.plos.org/plosbiolog… Is thymic involution consequential for immune responses? If you could figure out how to prevent it, or reverse it, would it matter?
Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice

Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice

Age-related thymic decline impairs T-cell immunity and increases infection risk in the elderly. This study shows that enhancing thymic function in aged mice restores naïve T cells and improves immune...

journals.plos.org
1
1
47
Our colleagues will of course decide whether the new NK classification proposed by @EricVivier1 is useful. What their decision, I do think a classification that makes sense of both mouse and NK subsets would be very useful to the field.
88
Our contribution was to show that mouse NK cells develop by 2 pathways, and that the transcriptional signatures that defined these 2 mouse NK subsets also distinguished human NK subsets defined by CD56.
99
Glad to have contributed to the work by Rebuffet, @EricVivier1 and colleagues, reposted below.
78
Vivier and colleagues integrated scRNA-seq and CITE-seq data to provide a resource of human NK cell heterogeneity in healthy tissues and in the tumor setting. Read it here: rdcu.be/dM61D nature.com/articles/s41590-0…
1
15
92
10,531
And here are the links to the two new papers in Nature Immunology. From us and our collaborators @SimonGrassmann, @SunLab_Official, @BelkaidLab nature.com/articles/s41590-0… From the lab of Bendelac and McDonald: nature.com/articles/s41590-0…
2
7
1,137
And here is the thoughtful N&V from Emma Patey & @bjorkstrom_lab nature.com/articles/s41590-0…
1
5
219
Such a bittersweet surprise to be back to back in Nature Immunology with Albert. To my thinking, our two papers are very complementary.
102
The original papers are here, one from our lab, one from the lab of Albert Bendelac. rdcu.be/dKS3i rdcu.be/dKS9d
1
99
Bhandoola_Lab retweeted
ImmuNoah'sArk (@immunonoah) profile picture
ImmuNoah'sArk@immunonoah15 Jun 2024
Great summary from Emma Patey & @bjorkstrom_lab about the 2 recent papers studying NK cell developmental origins from the late Bendelac's lab & the Bhandoola's lab: nature.com/articles/s41590-0… ILCs with more nuance! Orginal studies: rdcu.be/dKS3i rdcu.be/dKS9d
Image from ImmuNoah'sArk (@immunonoah)
3
9
1,124
Bhandoola and colleagues describe the existence of two developmental pathways that give rise to functionally distinct NK cell subsets. Read it here: rdcu.be/dKPp7 nature.com/articles/s41590-0…
1
13
3
43
10,318
The CCR media team has a succinct outline of this latest work from our lab: nitter.cf/NCIResearchCtr/status/…
2
3
400
Bhandoola_Lab retweeted
Immunity (@ImmunityCP) profile picture
Immunity@ImmunityCP26 Apr 2024
Online now: Transcription factor Tox2 is required for metabolic adaptation and tissue residency of ILC3 in the gut dlvr.it/T63Tgk
17
73
10,497
science.org/doi/full/10.1126… Other recent work from our lab. Stay tuned for more.
Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus...

Expression of the transcription factor Klf6 by thymic epithelial cells is required for thymus...

Klf6 is required in thymic epithelial cells for normal thymic development and the establishment of T cell tolerance.

science.org
1
112
And here's the link to the paper itself, below. nature.com/articles/s41586-0…
Bone marrow plasma cells require P2RX4 to sense extracellular ATP

Bone marrow plasma cells require P2RX4 to sense extracellular ATP

Nature - We demonstrate the role of the ligand-gated purinergic ion channel P2RX4 in maintaining mouse plasma cells in their bone marrow niche.

nature.com
1
104
Bone marrow plasma cells require P2RX4 to sense extracellular ATP rdcu.be/dyDzS The link is to a web-readable version of our lab's first paper on plasma cells. From a very fun collaboration between our lab at the National Cancer Institute and David Allman's lab at Penn.
1
87
Load more