CEO @artan_bio · Codon Therapy for the mutations of aging · Bay Area ↔ St. Pete · Science, longevity, family
San Francisco Bay Area
Joined May 2025
- Tweets581
- Following250
- Followers166
- Likes402
Brian Bodemann retweeted
Attention $VITARNA token holders:
We want your feedback on a proposed experiment! Token holders actually have a say! Vote below. This is #desci in action!
snapshot.org/#/s:vitarna.eth…
@vitarnabio @vita_dao @Molecule_sci @BioProtocol @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
For those interested, we share updates on the Vitarna Telegram thread here:
t.me/vitarna
Brian Bodemann retweeted
Attention $vitarna token holders. Here’s another thread on the data of our therapeutic:
Does the codon suppressor reach tissue? We dosed mice once with AAV9 and measured codon suppressor expression 14 days later. 🧬👇
@vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
Attention $vitarna token holders:
Artan-102 restores full-length p53 in Calu-6 cells with R196X on both alleles.
R196X is a CGA→TGA stop. The Artan-102 band runs stronger than the G418 control. Not quantitative. 🧬
@vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
The big banks are catching on. What we’re doing in the desci space is different! @vitarnabio @vita_dao @artan_bio
Brian Bodemann retweeted
What would happen if we could stop the functional consequences of somatic mutations we know accumulate over time?
Let's walk through what the data say. 🧬👇
@vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
Attention $vitarna token holders and longevity enthusiasts. As we go into @Jefferies London, we’re sharing more the science behind Artan. You’ll see how we’re different.
The problem:
One C→T change at a CGA codon turns arginine into a premature stop. It happens on its own, and it builds up with age.
Here's how it works and why it's the stop we built around. 🧬👇
@vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
1/6 🧬 A single genetic letter can stop a critical protein from being made.
What if we could restore it?
Human genetic research in Parkinson’s disease highlights exactly the class of mutations ARTAN Bio’s VitaRNA technology is designed to address.
Here’s why this matters for $VITARNA. 🧵 @vitarnabio @vita_dao @artan_bio @Bodeeeman @aschwartzphd
Brian Bodemann retweeted
No success so far in using fusion to turn mercury into Bitcoin, thankfully.
Last month, we demonstrated high-rate alchemy: turning mercury into real, stable gold, beating CERN’s record by a factor of 10.
Last week, we enriched isotopes in the world’s most powerful plasma centrifuge, beating the Soviet record that stood for 40 years.
Now, we’re building a fusion reactor in San Francisco to achieve record power density.
Brian Bodemann retweeted
Excited to receive this award! Hope to see some friends attend! Let’s keep building!
Brian Bodemann retweeted
Looking forward to representing @artan_bio at the @spARKbyARK Innovation Showcase here in St Pete. ARTAN, with the help of @vitarnabio $vitarna token holders is going after unique biology that addresses all 12 Hallmarks of Aging versus the more singular approaches of others!
Brian Bodemann retweeted
Arginine…
Can a single transfer RNA drive prostate cancer treatment resistance?
A new @Nature study found that loss of one tRNA, tRNA1-Arg(UCU), pushes prostate cancer cells toward a neuroendocrine-like state and makes them resistant to androgen receptor-targeted therapies. Restoring it reversed this shift and restored drug sensitivity in experimental models.
The mechanism involves SMARCC2, a SWI/SNF subunit important for maintaining AR signaling. Its mRNA is enriched in codons decoded by this tRNA, so when tRNA levels fall, SMARCC2 protein levels also decline.
In patient samples, low tRNA levels were associated with earlier metastasis and shorter survival.
No therapeutic delivery yet, but a striking link between codon biology, cancer cell identity, and treatment resistance.
Brian Bodemann retweeted
The cities of San Diego, Las Vegas, and Salt Lake City are all in the cone of Pacific Hurricane Rachel tonight.
Brian Bodemann retweeted
Fam, we building in St Pete, Florida with @spARKbyARK @ARKInvest. Time to put them gains to work @CathieDWood!
Brian Bodemann retweeted
Interesting talk from @ARTAN_bio!
I was totally unfamiliar with stop codon emergence and possible Tx applications. Bold approach to an under-appreciated problem!
Packed house for the @ARTAN_bio talk tonight @ARDD_Meeting . I assume everyone wants to learn about Longevity Codon Therapy, $VITARNA, and fundraising on @BioProtocol with @vita_dao
Brian Bodemann retweeted
Check out this thread from our @artan_bio CEO! He’ll be presenting at @ARDD_Meeting! Reach out to him or me to connect! Happy to make the intro! @aschwartzphd @vitarnabio @vita_dao @Molecule_sci $vitarna
Most aging research is trying to reset cells, clear them out, or swap the plasma. Those approaches matter, but they still leave one class of aging damage in place. #ARDD26
