Bothwell Lab (@Bothwell_Lab) profile picture

Bothwell Lab

@Bothwell_Lab

We study novel functions of Wnt antagonists DKK1 and DKK2 in the immune response, trogocytosis, and cancer.

 Tucson, AZ
bothwelllab.github.io
Joined January 2022
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  • Followers39
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Photo by Bothwell Lab (@Bothwell_Lab)Photo by Bothwell Lab (@Bothwell_Lab)Photo by Bothwell Lab (@Bothwell_Lab)Photo by Bothwell Lab (@Bothwell_Lab)Photo by Bothwell Lab (@Bothwell_Lab)
Read all about #CancerTrogocytosis in our latest publication: Colon cancer cells acquire immune regulatory molecules from tumor-infiltrating lymphocytes by trogocytosis | Proceedings of the National Academy of Sciences pnas.org/doi/10.1073/pnas.21…
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Congratulations to our graduate student Dr. @HaleyMarcarian (far right in image) who showed off her MAD Scientist skills yesterday and successfully defended her dissertation at the University of Arizona! Note: Picture was taken in a lab/zombie-themed escape room
Image from Bothwell Lab (@Bothwell_Lab)
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Our excellent graduate students @anutr_sivakoses and @HaleyMarcarian recently co-authored a review article on contact-dependent cell trafficking mechanisms that was published this morning! mdpi.com/3393540 #mdpicancers via @Cancers_MDPI
Molecular Dynamics of Trogocytosis and Other Contact-Dependent Cell Trafficking Mechanisms in Tumor...

Molecular Dynamics of Trogocytosis and Other Contact-Dependent Cell Trafficking Mechanisms in Tumor...

Horizontal trafficking of subcellular components, such as nucleic acids, proteins, and membrane fragments, is utilized by tumor cells to facilitate tumor cell proliferation and survival. Convention...

mdpi.com
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The Bothwell Lab has a brand new publication out now! Our fabulous graduate student @HaleyMarcarian investigates protein and DNA trafficking in renal cancers. Read now: journals.plos.org/plosone/ar…
Renal cancer cells acquire immune surface protein through trogocytosis and horizontal gene transfer

Renal cancer cells acquire immune surface protein through trogocytosis and horizontal gene transfer

Trogocytosis is an underappreciated phenomenon that shapes the immune microenvironment surrounding many types of solid tumors. The consequences of membrane-bound proteins being deposited from a donor...

journals.plos.org
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The Bothwell Lab has a brand new publication out now! Our fabulous graduate student @HaleyMarcarian investigates protein and DNA trafficking in renal cancers. Read now: journals.plos.org/plosone/ar…
Renal cancer cells acquire immune surface protein through trogocytosis and horizontal gene transfer

Renal cancer cells acquire immune surface protein through trogocytosis and horizontal gene transfer

Trogocytosis is an underappreciated phenomenon that shapes the immune microenvironment surrounding many types of solid tumors. The consequences of membrane-bound proteins being deposited from a donor...

journals.plos.org
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Congratulations to our new (almost) graduates @HaleyMarcarian and @anutr_sivakoses for nearing the completion of their PhD! They recently returned to the U of A for their hooding and will be defending in early August.
Image from Bothwell Lab (@Bothwell_Lab)
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Our new lab's manuscript was published today! Please be sure to give it a read!
Anutr Sivakoses (@anutr_sivakoses) profile pictureAnutr Sivakoses@anutr_sivakoses31 Mar 2025
Super excited to share my first scientific publication investigating TNBC trogocytosis of immune cells: peerj.com/articles/19236/
Triple negative breast cancer cells acquire lymphocyte proteins and genomic DNA during trogocytosis...

Triple negative breast cancer cells acquire lymphocyte proteins and genomic DNA during trogocytosis...

Trogocytosis is the process by which a recipient cell siphons small membrane fragments and proteins from a donor cell and can be utilized by cancer cells to avoid immune detection. We observed...

peerj.com
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We had an amazing holiday lab lunch/white elephant gift swap yesterday with @DrJoannSweasy and @DuctalvsAcinar's labs yesterday! Thank you for inviting us and we are looking forward to our future collaborations!
Image from Bothwell Lab (@Bothwell_Lab)
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Congratulations @lincolnstrick!! Thanks to @anutr_sivakoses @HaleyMarcarian @ihedioho and committee members @Bothwell_Lab @DrJoannSweasy and Rakesh Singh for their feedback and support!
Lincoln Strickland (@lincolnstrick) profile pictureLincoln Strickland@lincolnstrick11 Nov 2024
First thesis committee meeting: ✅! Thank you to my advisor, @DuctalvsAcinar for her mentorship. Also thank you to the very kind members of the @Bothwell_Lab who helped me prepare for the meeting and who surprised me with this cake afterward!
Image from Lincoln Strickland (@lincolnstrick)
Image from Lincoln Strickland (@lincolnstrick)
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Proud moment as @lincolnstrick was selected to give a lighting talk at the #EppleyInstitute symposium. She gave an excellent talk on how repeated radiofrequency ablation changes #neutrophil function in #PancreaticCancer!! @BuffettCancer @UNMC_PathMicro
Image from Jennifer Bailey-Lundberg (@DuctalvsAcinar)
Image from Jennifer Bailey-Lundberg (@DuctalvsAcinar)
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Congratulations to Bothwell Lab Members @anutr_sivakoses, @HaleyMarcarian, and @ihedioho, as well as @lincolnstrick from the @DuctalvsAcinar lab for giving amazing lightning talks (Lincoln and Haley) and poster presentations!
Image from Bothwell Lab (@Bothwell_Lab)
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(1/2) Congratulations to our wonderful postdoc @ihedioho on her article's acceptance to Frontiers in Immunology The full manuscript will be available at the link below:
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(2/2) Frontiers | Leishmania major surface components and DKK1 signalling via LRP6 promote migration and longevity of neutrophils in the infection site (frontiersin.org/journals/imm…)
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Welcome to the BCC @DuctalvsAcinar! Super excited to work with you and @lincolnstrick.
Jennifer Bailey-Lundberg (@DuctalvsAcinar) profile pictureJennifer Bailey-Lundberg@DuctalvsAcinar27 Sep 2024
Celebrating 10 years since the lab opened in Sept 2014 and receiving a @DeptofDefense @CDMRP #PancreaticCancer Idea Development Award NOA! Huge thanks to @lincolnstrick for making a thoughtful cake. Grateful for our steadfast collaborators & the dedication of every lab member🫶🏻
Image from Jennifer Bailey-Lundberg (@DuctalvsAcinar)
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Congratulations to our PostDoc, Olivia, who recently published her article on Leishmania LPGs influence DKK1 production and platelet cell activation in @FrontImmunol! Open-Access: frontiersin.org/articles/10.…
Frontiers | Leishmania major-derived lipophosphoglycan influences the host’s early immune response...

Frontiers | Leishmania major-derived lipophosphoglycan influences the host’s early immune response...

Platelets are rapidly deployed to infection sites and respond to pathogenic molecules via pattern recognition receptors (TLR, NLRP). Dickkopf1 (DKK1) is a qu...

frontiersin.org
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Bothwell Lab retweeted
Zavros Lab (@ZavrosL) profile picture
Zavros Lab@ZavrosL14 Feb 2023
AddThis | Home doi.org/10.1016/j.trsl.2023.… We are excited to share the new article published by our lab! @JayatiChakraba2 @UAZMedTucson @uarizona @MarthaDu @heartresearchUS
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Check out Zavros’s lab manuscript on iPSC derived corticotroph organoids to study Cushing disease!
Zavros Lab (@ZavrosL) profile pictureZavros Lab@ZavrosL14 Feb 2023
AddThis | Home doi.org/10.1016/j.trsl.2023.… We are excited to share the new article published by our lab! @JayatiChakraba2 @UAZMedTucson @uarizona @MarthaDu @heartresearchUS
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Missed the #NationalMentoringMonth 2023 Webinars? No problem! Check out our YouTube page: youtube.com/channel/UCjjGfIw…
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INFECTION AND INFLAMMATION AS DRIVERS OF AGING SYMPOSIUM THURSDAY, JANUARY 12, 2023, 9:00AM, KEATING 103
Image from UAZImmunobiology (@ImmunobiologyUA)
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Bothwell Lab retweeted
BIO5 Institute (@UAZBIO5) profile picture
BIO5 Institute@UAZBIO522 Nov 2022
Gain knowledge from @uarizona Immunologist Dr. Deepta Bhattacharya as he weighs in on why kids are experiencing a resurgence of respiratory viruses.➡️bit.ly/3ADQyKZ #Immunobiology
A child with a blue face mask.

ALT A child with a blue face mask.

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Bothwell Lab retweeted
NSURPorg (@NSURPorg) profile picture
NSURPorg@NSURPorg15 Nov 2022
We are thrilled to congratulate #NSURP2022 student Alexis on her @ABRCMS poster award!!! #ABRCMS2022 #nolabnoproblem
Image from NSURPorg (@NSURPorg)
Image from NSURPorg (@NSURPorg)
Image from NSURPorg (@NSURPorg)
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