Brad Clark

Mark your calendar — April 25, 10:00 AM. Excited to present at the HRS Late-Breaking Clinical Trials – High Impact Science Session. 📍 McCormick Place, Room S103 “Reentry at Patient-Specific Regions with Steep Repolarization Gradients Is a Mechanism of AF Initiation” This work reflects years of effort by an extraordinary team. Importantly, it marks a major advance in our understanding of AF mechanisms, one that can move the field forward by enabling a shift from empiric therapy toward patient-specific targeting of the substrate responsible for AF initiation and maintenance. We set out to answer fundamental questions: 1.What is the mechanism of AF initiation? 2.Is there a localized substrate? 3.What are its ep properties? 4.Can it be identified during sinus rhythm? 5.Can targeted ablation eliminate AF? This study answers all of these questions and also provides proof-of-concept clinical validation supporting a mechanism-driven, patient-specific approach to AF ablation. For too long, ablation strategy has remained largely empirical. We hope this work moves us closer to a truly mechanism-based approach.