We study how circadian time is processed in the brain. We do biology, some electronics, a bit of mathematics, and just a tint of philosophy.
Taipei City, Taiwan
Joined February 2017
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Veronica's model pictures mood on a washboard (빨래판) potential and proposes how the brain’s clock may stabilize mood. The circadian clock rhythmically tilts it and sustains daily “ups and blues” while helping keep mood from sliding into deep depression.
doi.org/10.1063/5.0327423
The Chronotype Paradox: intrinsic circadian periods are slightly left-skewed, yet human chronotypes are heavily right-skewed. We show stochasticity in sleep pressure accumulation is sufficient to flip the skew. biorxiv.org/content/10.64898…
Circadian swings in the mood potential protect against falling into mood extremes such as mania and depression, and this helps explain why bipolar disorder and circadian dysfunction subtly interact. Work by Veronica Will (now at UCSD).
biorxiv.org/content/10.64898…
We know use of affective words show circadian fluctuations. Now Vuong and Mariana show circadian structure in embedding space, too: morning peak in local semantic exploration, later peak in global diversity as posts accumulate. arxiv.org/abs/2601.15091
Ben Nguyen explaining his mathematical model of chronotype at the Taiwan Sleep Society Meeting (October 2025).
Vuong presenting his work on the origins of the heart's circadian rhythm at the Japanese Chronobiology Society 2025 @jsc2025_kyoto meeting in Kyoto. (ヴオンの初めての時間生物学会での発表) #JSC2025
Circadian biologists from Korea, Japan, and Taiwan got together at #KSBNS2025 — Jihwan Myung, Eun Young Kim, Kazuhiro Yagita, and ShihKuo Chen!
Braintime Lab’s Vuong and Sun Lab’s Mariana took a joyful moment to celebrate their upcoming marriage💍 with a one-of-a-kind photo shoot!
#BraintimeLab #SunLab #LoveInTheLab #CircadianRhythms #BuryingBeetles #ScienceAndStory
Our super-postdoc Hélène is back from GRS/GRC after her wonderful talk and poster presentation! We still need to absorb what she learned there—but we are so proud of her. #GRC2025 #HeleneVitet
Our amazing master's student Veronica has officially graduated! Huge congratulations from all of us at Braintime Lab!
Circadian clocks in the body likely 'entrain' themselves rather than hierarchically reset. Given internal cellular feedback, omics (Bharath @TimelyScientist) may accurately predict their phases via connectomics, something single-gene reporters cannot. doi.org/10.1016/j.sleep.2025…
We had an exciting open lab at Braintime Lab! Helene and Vuong prepared hands-on experiments with mock mouse brains containing a mock SCN, which we visualized using fluorescence, and we tried mock Western blot and genotyping. But the experience was real!
Ilia Karatsoreos visited us and gave an awesome, inspiring talk on November 1st about 'Biological Time and the Prefrontal Cortex: Function and Dysfunction'.
