| Bram Vermeulen | PhD student at @PfefferCryoLab | Heidelberg
Nieuwegein
Joined October 2011
- Tweets72
- Following88
- Followers49
- Likes66
Bram Vermeulen retweeted
We are excited to share our latest work elucidating the structural basis for how augmin binds to microtubules. Out just now @NatureComms:
nature.com/articles/s41467-0…
Bram Vermeulen retweeted
Online today at @NatureComms: in a major team effort, we reveal the structural mechanisms for centrosomal recruitment and organization of the human microtubule nucleator γ-TuRC: nature.com/articles/s41467-0…
Bram Vermeulen retweeted
Out just now at @NatureComms and a great start into the New Year: we reveal how yeast cytoplasmic γ-TuRC is assembled and activated by dimeric CM1 motifs of the receptor protein Spc72 and how the microtubule polymerase Stu2 binds to promote MT assembly. nature.com/articles/s41467-0…
Bram Vermeulen retweeted
We have an open PhD position to explore structures of gamma-tubulin ring complexes using cryo-EM approaches here in our group @ZmbhH
@UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School @HBIGS_HD : hbigs.uni-heidelberg.de
Bram Vermeulen retweeted
We still have open PhD positions here in our cryo-EM group @ZmbhH @UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School or directly send us your application documents.
hbigs.uni-heidelberg.de/
We have two open PhD positions to explore structures of ribosomes and gamma-tubulin complexes using cryo-EM approaches here in our group @ZmbhH @UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School @HBIGS_HD: hbigs.uni-heidelberg.de/
Bram Vermeulen retweeted
We have two open PhD positions to explore structures of ribosomes and gamma-tubulin complexes using cryo-EM approaches here in our group @ZmbhH @UniHeidelberg.
Please apply via the Heidelberg Biosciences International Graduate School @HBIGS_HD: hbigs.uni-heidelberg.de/
Bram Vermeulen retweeted
Cryo-EM of native γ-TuRC-capped microtubules from frog egg extracts shows transition from open to partly closed conformation, with local misalignments in the RanGTP-dependent nucleation pathway
Elmar Schiebel, @PfefferCryoLab et al @ZmbhH @UniHeidelberg
embopress.org/doi/full/10.10…
Very excited that our work describing the structure of native y-TuRC-capped microtubules is finally out! Special thanks to our great collaborators, especially my co-first authors @QIGAO31314616 and Anna Böhler.
Out just now @embojournal: our cryo-EM structure of the native RanGTP-induced γ-TuRC-capped microtubule, revealing a surprisingly asymmetric minus end architecture with direct implications for microtubule regulation and modulation during spindle assembly.
embopress.org/doi/full/10.10…
Bram Vermeulen retweeted
We report the discovery & mechanism of #Clovibactin, an #antibiotic from unculturable bacteria!
⬇️⬇️ @CellCellPress ⬇️⬇️
💊 doi.org/10.1016/j.cell.2023.…
Clovibactin uses a 'hydrophobic cage' motif to target the cell wall and kill without detectable resistance
@UniUtrecht
1/n
ALT The newly discovered antibiotic Clovibactin from unculturable bacteria, also known as 'microbial dark matter. Clovibactin uses an unusual cage-like binding motif to tightly wrap around immutable pyrophosphate of cell wall precursors, but ignores the variable sugar-peptide part. This enables Clovibactin to target different, indispensable cell wall precursors (Lipid II, Lipid III, C55PP) in bacterial cell membranes, and it makes the drug extremely robust to the development of antimicrobial resistance. Clovibactin does even more: Upon target binding, it assembles to fibrils on the membrane surface. These fibrils help to stably binds the target as long as it takes. Altogether, Clovibactin is a promising lead for the development of next-generation therapeutics with a long clinical lifetime. PS: The name comes from the binding motif - 'Klouvi' means cage in Greek. Illustration by Gloria Fuentes from 'The Visual Thinker'
Bram Vermeulen retweeted
We have three open PhD positions funded under our #ERCStG 'RiboStress' to explore how cells remodel the activity and molecular organization of the translation machinery in response to stress.
If you are interested apply via the HBIGS graduate program: my-hbigs.uni-heidelberg.de/s…
Bram Vermeulen retweeted
Three articles on augmin structures using
#Alphafold & #cryoEM in only two weeks.
Congratulations to @lchangpurduebio, @RuiZhangWUSTL, @LabPetry and our collaborators @EustermannLab and the Schiebel Lab!
nature.com/articles/s41467-0…
biorxiv.org/content/10.1101/…
nature.com/articles/s41467-0…
Bram Vermeulen retweeted
How do you grow a microtubule tree? We provide structural insights into the formation of microtubule branches by using #AlphaFold and integrative structural biology to elucidate the molecular architecture of the branching factor Augmin.
nature.com/articles/s41467-0…
Bram Vermeulen retweeted
📣📣📣We are looking for PhD students & postdocs to join our lab for projects on #structuralbiology & #antibiotic mechanisms
➡️Please do get in touch or apply by Sept 20.
➡️Unroll to find the adds check weingarth-group.org/position…
#phdpositions #NMR
#postdocpositions
1/4
Bram Vermeulen retweeted
#Teixobactin, isolated from 'unculturable' bacteria, is considered the first new 💊#antibiotic💊 in 30 years. But how does it kill bacteria?
We show teixobactin uses a new mechanism that involves a double attack on the cell envelope
Out @Nature
nature.com/articles/s41586-0…
#NMR 1/n
ALT Teixobactin uses a new 'two-pronged' mechanism to kill bacteria
Bram Vermeulen retweeted
Ion channel textbook knowlege: The filter of K+ channels constricts upon inactivation.
Our new study in @NatureComms refutes this:
rdcu.be/cJDq5
👏Collaboration with Roux group
#ionchannels #nmr @UUBeta
Bram Vermeulen retweeted
How do cells fire up the #RQC engine? Check out our structural and mechanistic blueprint for bacterial #ribosome collision sensing by MutS2, out today in @Nature. MutS2 senses collisions and splits ribosomes to initiate RQC!
nature.com/articles/s41586-0…
Bram Vermeulen retweeted
How do you assemble a microtubule nucleator? Here are the step-by-step instructions.
We are excited to share our work on the structural basis of γ-TuRC assembly. Great collaboration with the Schiebel lab @ZmbhH.
nature.com/articles/s41467-0…
Proud to share the work done during my master's thesis in the Weingarth lab, together with the Roux lab!
We reveal that inactivation of voltage-gated potassium channels is probably different than has been assumed in the field for over a decade.
Bram Vermeulen retweeted
The Pfeffer Lab @ZmbhH @UniHeidelberg is finally on Twitter.