Bunk Police

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Could mebufotenin, a psychedelic compound found in Sonoran Desert toad venom, lead to a new treatment for treatment-resistant depression? 🐸 A phase 2b trial studied a single-dose nasal spray formulation in 193 adults whose depression had not responded to multiple antidepressant trials. Participants received an 8-milligram dose, a 12-milligram dose, or a very low-dose comparator, along with psychological support. Both active doses were associated with greater reductions in depression scores than the comparator, with differences observed for up to 57 days. Most side effects were mild or moderate, and most participants were considered ready for discharge within two hours. This was a clinical trial of a nasal spray formulation—not raw toad venom. The findings are promising, but the treatment is still being studied and needs further research. 🔬 For information about mail-in lab analysis, visit TransparencyTesting.com. Source: futurism.com/health-medicine…

Knowing what a sample may contain and knowing how much is present are different questions. Reagents can show reactions consistent with LSD or another indole, but they can’t confirm the substance or measure its dose.

Could a psychedelic compound found in toad venom treat depression when snorted? A Phase 2b trial of 193 adults with treatment-resistant depression found that a single dose of nasal mebufotenin reduced symptoms, with effects lasting weeks. Participants received one 8 mg or 12 mg dose, or a very low comparator dose, alongside structured psychological support. Average improvement was around 30%, and remission rates were below those typically seen with ketamine or electroconvulsive therapy.

Potency testing and lab analysis answer different questions. The Psilocybin QTest estimates potency at home; lab testing can analyze an eligible submitted sample for psilocybin, psilocin, and other tryptamines. ✅️ TransparencyTesting.com

In a small randomized Swedish trial of 35 adults with depression, several participants improved within 48 hours of a single 25 mg psilocybin dose. Remission was reported by 53% at six weeks versus 6% on placebo, but the groups no longer differed significantly at one year.

LSD blotter reacting to the Ehrlich reagent 🧪 Ehrlich is the reagent that matters most for blotter, since it detects indoles and actually reacts with LSD when many other reagents stay clear. A genuine blotter turns purple/pink, which is a strong sign you’re looking at a real indole like LSD. 🔎 View the world’s largest lab-verified reagent reaction video library, featuring 1,000+ substance reactions, free on the Transparency Harm Reduction App or Vimeo. ✅️ Remember the Transparency Triple Check for confident testing: Check for adulterants with test strips, identify your substance with multiple reagents, and verify your results with the Transparency Harm Reduction App 📲

Minnesota’s opioid deaths fell for a third straight year, but overall overdose deaths rose. 📉 In 2025, Minnesota’s opioid-involved deaths fell for the third year in a row, from a high of 1,039 in 2022 to 671. Fentanyl-involved deaths also declined, from 602 in 2024 to 564 in 2025. But the overall overdose picture moved in the other direction: deaths involving all drugs rose from 994 to 1,025. Minnesota health officials say the increase was driven by stimulant-involved deaths, including methamphetamine and cocaine. Hospitalizations for nonfatal stimulant overdoses also increased. The state launched a new alert system in October that uses EMS data to spot local overdose spikes and emerging drug threats. More than 75 Minnesota counties have provided contacts for the system. 🧪 Testing gives you more information about a sample, but no single test can tell you everything. Follow the Transparency Triple Check: SCREEN with test strips, IDENTIFY with multiple reagents, and VERIFY results with the free Transparency Harm Reduction App 📲 Source: startribune.com/overdose-dea…

A recent small pilot trial at UCSF studied 12 adults aged 40–75 with mild-to-moderate Parkinson’s disease and mood symptoms. Participants received 10 mg of psilocybin followed by 25 mg about two weeks later. Researchers observed lower combined inflammation-marker scores at three follow-ups, including 30 days after the second dose. Some individual markers, including IL-6, IL-8 and C-reactive protein, decreased after the first dose. A mitochondrial stress marker also fell, but that change was no longer statistically significant after 30 days

In a federally funded survey of 1,023 recent cannabis consumers, dispensary staff were more trusted overall than clinicians or government officials. Dispensary staff had the highest average trust rating, 3.7 out of 5, followed by friends at 3.5 and healthcare providers at 3.4. State and federal officials averaged 2.9. The most trusted source varied by reason for use: 55% of respondents seeking medicinal use chose healthcare providers, while 47% of those using cannabis for fun or relaxation chose dispensary staff.

Your harm reduction routine shouldn’t stop at a fentanyl test strip. 🧪 Before you partake, follow the Transparency Triple Check protocol: 🔍 SCREEN with test strips to check for specific adulterants. 🧪 IDENTIFY with multiple reagent tests to help determine what substances may be present. 📲 VERIFY your results using the free Transparency Harm Reduction App to compare reactions. Then take it one step further with SprayPack! SprayPack lets you create a DIY nasal spray with a customized amount per spray, offering a potentially less irritating alternative to snorting powder and a more consistent way to measure intake. No method eliminates risk, but combining harm reduction tools can help you make more informed decisions. ✅ Learn more at BunkPolice.com and download the free Transparency Harm Reduction App today 📲

A small pilot study of 48 adults found that women who received 15 micrograms of LSD responded about 8% faster on one sustained-attention task and had fewer attention lapses. Researchers didn’t observe a comparable improvement among men. bunkpolice.com/does-lsd-micr…

The Pentagon is funding development of an under-the-tongue ketamine wafer, Wafermine, for battlefield pain, building on ketamine’s existing military use. The $40.95 million project is still in clinical development and has not been authorized or deployed. A reported licensing issue with the proposed U.S. manufacturing partner could complicate production and timing.

In a new mouse study, psilocybin increased the formation of dendritic spines (small structures that help neurons connect) within 24 hours. Many of these new connections persisted for weeks. Chronically stressed mice showed a greater increase in new connections and less loss of existing ones than healthy mice, suggesting the effects may depend on the brain’s starting condition. Manipulating serotonin receptors in specific neurons has allowed researchers to produce structural changes without the head-twitch response used as a behavioral proxy for psychedelic effects in mice.

The friend everyone needs in their festival crew. 🫶 Test strips, reagents, and SprayPack? That’s a festival essential lineup! Start with the Transparency Triple Check: Screen, Identify, and Verify. 🔍 Use test strips, multiple reagents, and the FREE Transparency Harm Reduction App to help make more informed decisions. Then, explore SprayPack for a more measured approach, with customizable dosing per spray. ✅ Find everything at BunkPolice.com!

Uruguay became the first country to fully legalize cannabis, and Montevideo’s ExpoCannabis is now preparing for its 13th edition. The event brings together cannabis and hemp brands, speakers and educators, with a focus on exhibitions, workshops and medical information rather than promoting consumption. ExpoCannabis Uruguay has grown to 180 participating brands and 60 program formats across its first 12 editions.

Wastewater estimates suggest cocaine consumption in England rose 26% from 2021 to 2025, reaching about 123,000 kg in 2024–25, with an estimated street value of £9.8 billion. Survey data does not show a matching increase in the number of people reporting cocaine use. In England, 33,612 people began treatment for cocaine problems in 2024–25, up 57% from 2019–20. People in their 30s were the largest group seeking help. Cocaine-related deaths in England and Wales have also reached record levels, with more than half of deaths registered last year involving people over 40.

Psilocybin research in Parkinson’s is beginning to look beyond mood symptoms. Researchers measured five blood markers related to inflammation. The overall inflammation measure was lower after treatment and remained lower 30 days after the final dose. A mitochondrial stress marker, GDF-15, fell shortly after each dose but was no longer significantly lower at 30 days. Participants knew they were receiving psilocybin, and the study had no control group.