Cat Mak

The Energy Resistance Principle (ERP) is probably the most important paper and theory we've published. authors.elsevier.com/a/1luVK… The ERP bridges physics and biology, providing a first-principles understanding of the central force behind health and disease dynamics. Delightful to write this with lovely biophysicist @msahsorin. We are grateful for the dozens of colleagues, friends, and lab members who have contributed to sharpening the ideas, concepts, and definitions in the ERP. The ERP is a quantitative framework that can be used to understand some profound things that we know matter for our health: ☯︎ Why is exercise good for us? ☯︎ How does ketosis work as a treatment for mental illness? ☯︎ Why do we age well or not so well? ☯︎ Where does fatigue and the need to sleep come from? ☯︎ Why is the brain warmer than other tissues? ☯︎ How can we measure energy resistance (éR)? ERP's key idea is that we live in a narrow zone of energy resistance (éR). For energy to transform into metabolites, cells, organs, and thoughts, it needs to run through éR. Too little resistance, you would burst into flames. Too much resistance, your energy cannot flow easily, you feel tired, become inflamed, age faster, and get sick more easily. When éR is too high, we die. A new era of science is upon us. We have new theories, and are developing new tools and technologies to monitor energetic states, not just their molecular and physical expressions. This opens new avenues to develop the first field of science devoted to understanding health, and what sustains it: the healing process. It's time for Healing Science. We'd love to hear your thoughts, ideas, and questions. Please join us for a X space discussion on Oct 21. Details to follow.

Some of what makes each of us unique is likely to be expressed in mitochondria Discussion on a new paper here: mitoworld.org/how-evolution-… The paper: cell.com/cms/10.1016/j.xgen.… Probing the role of mitochondria as driver of psychobiological differences in humans: cell.com/trends/endocrinolog…