RANP ..special interests dementia / delirium/ gerontology ..all views my own
Joined March 2016
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Frontiers | A new blue zone? exceptional late-life survival in Bolotana, Sardinia share.google/rKp29HTPrn7Wjv9…
Cathy McHale retweeted
DSiDC @dsidc.bsky.social is ready for the #36AEC @alzheimereurope.bsky.social conference in Dublin, Ireland.
We are thrilled to hear and share knowledge and best practice on #dementia.
Visit our stand in the Forum !
Testing for Alzheimer Disease in Asymptomatic Adults jamanetwork.com/journals/jam…
Cathy McHale retweeted
Last week above the city of Rhenen in The Netherlands. I had been wanting to photograph this church tower with these kinds of conditions for years, and I finally managed to do so. What a morning.
A water-pinning hot spot drives templated tau aggregation | PNAS pnas.org/doi/10.1073/pnas.26…
Cathy McHale retweeted
DYSLIPIDEMIA MASTERCLASS: From Lipid Profile to Treatment!
High LDL-C? Elevated triglycerides? What about Lp(a)?
This 8-part visual guide covers:
⭕Lipoproteins & lipid interpretation
⭕ Cardiovascular risk assessment
⭕ Primary & secondary dyslipidemias
⭕ Statins & non-statin therapies
⭕ Hypertriglyceridemia & pancreatitis prevention
⭕ Lp(a), HDL-C & special populations
⭕ Guideline-based treatment algorithms
Updated with the 2026 ACC/AHA Dyslipidemia Guideline and 2025 ESC/EAS Focused Update.
Learn it. Apply it. Save it.
Cathy McHale retweeted
Among older adults, #ADHD was associated with increased risk of later mild cognitive impairment or dementia, and higher genetic liability was also associated with greater risk.
ja.ma/4AUBaqT
ALT Figure 2 displays two graphs showing cumulative incidence of MCI or dementia by age. A: ADHD diagnosis (orange curve) shows higher incidence than No ADHD (blue), HR=4.11. B: High ADHD Polygenic Risk Score (orange) shows higher incidence than Low (blue), HR=1.35.
Frontiers | A new blue zone? exceptional late-life survival in Bolotana, Sardinia share.google/p3iOagoVrx0C1wo…
#IGS2026 highlight 💫 @AmyLynch4848 presentation of Systematic Review and Meta-Analysis on CGA for Older People Presenting to the Emergency department - eloquent and superb 👏👏
Thought provoking and excellent Symposium from @SPKennelly and @TonyFoleyUCC on Brain health, dementia risk reduction, and preparedness for a new era of disease modifying therapies #igs2026
Cracking presentation from @taylors2305 identifying limitations of current evidence surrounding cog rehab in pscd - importance of measuring with robust tools, not just once + more evolved definition of 'impairment'- need for core outcome set👏 #igs2026
Brilliant presentation by @josephine_zifen and @Claire_Aine showcasing all their hard work -Advancing Integrated Care for nursing home residents @TUH_Tallaght 👏👏focus on keeping residents out of the acute setting / getting them out quickly when they do come in #igs2026
Inflection points and transitions in Alzheimer’s disease
Alzheimer研究分野に於る2人の重鎮がNatureに論説を掲載
ADはAβ→tauの線形cascadeでなく、<100µmの組織domain毎に閾値(変曲点)を非同期に越えるmozaic過程であり、Aβ関連p-tau誘導(pTau217)が中核的転換点
治療効果は標的の遷移がまだ可逆かで決まる
#Alzheimers
#papers
nature.com/articles/s41586-0…
Cathy McHale retweeted
Comparing resting-state functional connectivity in 58 people with mild-to-moderate #Parkinsons scanned in the OFF-medication state & 24 neurotypical older adults revealed patterns of both increased & decreased functional connectivity across key motor areas
academic.oup.com/braincomms/…
Cathy McHale retweeted
Biological aging clocks as biomarkers of human aging: Biological basis, methodological design, and epidemiological implications
sciencedirect.com/science/ar…
Cathy McHale retweeted
The first Regional Network Hub for Rare Dementia Support has now been established at TUH. The inaugural meeting in Tallaght Library brought people together to share experiences and shape future support. This work reflects TUH’s strategy of co designing care with patients.
ALT Members of the TUH Institute of Memory & Cognition in Tallaght Library following the first meeting of the Irish Regional Network Hub of Rare Dementia Support
Unified long-read panel for Parkinson’s and repeat expansion disorders
Researchers designed a novel gene panel comprising 564 loci related to #Parkinsons, repeat expansion disorders, & other neurodegen. conditions, & performed adaptive sampling to jointly interrogate various variants (STXBP2, AP4S1, RARS2, ALS2, & CNBP)
nature.com/articles/s41531-0…
