Cell Chemical Biology

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Online now! Shared α-helix chimeraffibodies enable linker-free bispecific protein design dlvr.​it/TW411K #chembiol

Online now! Genetic dissection of rapid proteolysis identifies TXNDC15 as a key factor of ERAD and lipid homeostasis dlvr.​it/TW2K3f #chembiol

Online now! Proteasome inhibition bidirectionally regulates ferroptosis sensitivity dlvr.​it/TW0qWp #chembiol

Online now! Small-molecule modulation of VDAC enhances glucose-stimulated insulin secretion by promoting ATP flux dlvr.​it/TW03tS #chembiol

Structural basis and rational engineering of a thermophilic Cas13a for robust RNA detection dlvr.​it/TVzJVt #chembiol

Online now! Selective USP32 inhibition reveals endosomal ubiquitin signaling and enables cell-permeable activity-based probes dlvr.​it/TVzJV7 #chembiol

Beyond acetylation: Evaluating the emerging biology of lysine acylation dlvr.​it/TVxc1x

Chemoproteomic profiling of itaconate-derived protein modifications dlvr.​it/TVxYq4

Non-enzymatic protein modifications at the interface of metabolism and immunity dlvr.​it/TVxXRH

Understanding protein ISGylation, a multifaceted posttranslational modification dlvr.​it/TVxWHz

Targeting protein arginine methyltransferases to enhance cancer immunotherapy dlvr.​it/TVxTwG

Arginine methylation in immunoregulation: Mechanisms and therapeutic targeting dlvr.​it/TVxSzK

Protein arginine methylation rewires molecular interactions dlvr.​it/TVxRsF

Post-translational modifications in bacteria: From identification to function dlvr.​it/TVx7PB

Lysine methylation as a bidirectional switch dlvr.​it/TVx05V

Investigation of the classical histone deacetylases and sirtuins using peptide technologies dlvr.​it/TVwzPP

Chemical biology tools for studying histone post-translational modifications dlvr.​it/TVwyWc

Location, location, deUFMylation: Coordinating ribosome quality control at the ER dlvr.​it/TVwxjQ

Voices: Emerging molecular mechanisms and open questions in post-translational modifications dlvr.​it/TVwwm2