@CellRepMed

Broad-scope #OA journal from @CellPressNews publishing cutting-edge science across the spectrum of #Translational and #ClinicalResearch | Editor: @DrSaraHam

 USA, NLD, CHN, GBR, BEL
cell.com/cell-reports-medicine
Joined October 2019
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The new issue is out! Cover: Li et al. shows unsafe drinking water is linked to multiple health risks globally. The cover image—an auction for "the last glass of pure water"—highlights urgent need for policy action to reduce water-related disease. Follow us on LinkedIn for more!
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Online now: Allosteric modulation of YTHDFs by ellagic acid suppresses triple-negative breast cancer via non-canonical activation of the HIF-1α pathway dlvr.it/TVh7mR

Allosteric modulation of YTHDFs by ellagic acid suppresses triple-negative breast cancer via...

Zhou et al. identify ellagic acid (EA) as an allosteric inhibitor of YTHDF proteins that binds to a conserved site shared across YTHDF family members. By disrupting YTHDF2-mediated RNA decay, EA...

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Online now: A single-dose inhalable rAAV-vectored vaccine against mpox virus dlvr.it/TVgs84

A single-dose inhalable rAAV-vectored vaccine against mpox virus

Jiao et al. develop an inhalable, single-dose rAAV/DJ-vectored mpox vaccine. The optimal formulation, MV-C, elicits durable mucosal and systemic immunity, inducing neutralizing antibodies and...

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Meet Prof. Di Yu of @UQ_News in Hangzhou, China, at the Cell Press Symposium: Taking programmed cell death from mechanisms to interventions, and chat to him about his latest research on ferroptosis. Secure your seat: hubs.li/Q04yjs6B0 @CellPressEvents #CSCellDeath26
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Online now: Emerging role of GLP-1 mono, dual, and triple agonists in the management of MASH-related fibrosis dlvr.it/TVgMzM

Emerging role of GLP-1 mono, dual, and triple agonists in the management of MASH-related fibrosis

Tavaglione and Loomba review the emerging role of GLP-1 mono, dual, and triple agonists in MASH-related fibrosis. These therapies target multiple metabolic and inflammatory pathways and show promis...

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Online now: Surface display of co-stimulatory ligand B7H2 on engineered bacteria enhances tumor immunotherapy dlvr.it/TVgC6y

Surface display of co-stimulatory ligand B7H2 on engineered bacteria enhances tumor immunotherapy

Feng et al. develop surface-engineered bacteria as the living therapeutic for tumor immunotherapy. Bacteria are genetically programmed to display surface-anchored B7H2 to provide co-stimulatory...

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Online now: LungGPT: A unified multimodal system for interpretable diagnosis and clinical decision support of respiratory diseases dlvr.it/TVfsKS

LungGPT: A unified multimodal system for interpretable diagnosis and clinical decision support of...

Shao et al. present LungGPT, a multimodal artificial intelligence system that fuses clinical features, lab tests and imaging to enhance respiratory healthcare. LungGPT enables accurate diagnoses,...

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Online now: Preferential engagement of the anti-inflammatory ATP/adenosine axis by HIV vaccine candidate with V1-deleted envelope in male rhesus macaques dlvr.it/TVfgvL

Preferential engagement of the anti-inflammatory ATP/adenosine axis by HIV vaccine candidate with...

Silva de Castro, Rahman, Bissa et al. show that an HIV vaccine candidate with an Env V1 deletion reduces SHIV acquisition risk by 81%, whereas an intact-V1 candidate is not efficacious. Protection is...

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Online now: Enfortumab vedotin induces immunogenic cell death and shows enhanced preclinical antitumor activity when combined with a PD-1 inhibitor dlvr.it/TVf0Bs

Enfortumab vedotin induces immunogenic cell death and shows enhanced preclinical antitumor activity...

Olson et al. characterize multiple preclinical mechanisms associated with enfortumab vedotin activity, including direct and bystander cytotoxicity and induction of immunogenic cell death hallmarks....

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Meet Eileen Gentleman @GentlemanLab in Bruges @CellPressEvents #CPSOrganoidsNAMs27 and discover how her research is using innovative biomaterials to harness the potential of stem cells for regenerate medicine. Abstract submission deadline: Jan 22, 2027 hubs.li/Q04y4vQ_0
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Online now: Maternal secretor status and human milk oligosaccharides influence the infant gut resistome dlvr.it/TVd7Hn

Maternal secretor status and human milk oligosaccharides influence the infant gut resistome

Samarra et al. show that exclusive breastfeeding, through human milk oligosaccharides, shapes the infant gut resistome. Specific human milk oligosaccharides associate with reduced antibiotic resist...

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Online now: Fast tumor accumulation and payload release of c-Met targeting aptamer-drug conjugate enables robust anti-tumor efficacy dlvr.it/TVcbyZ

Fast tumor accumulation and payload release of c-Met targeting aptamer-drug conjugate enables...

Liu et al. developed a c-Met-targeting aptamer-drug conjugate (ApDC) that achieved robust anti-tumor efficacy across multiple c-Met-overexpressing tumor models through rapid tumor accumulation and...

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Online now: CRISPRa-identified transcription factors reprogram glioblastoma into dendritic cell-like cells to elicit systemic antitumor immunity dlvr.it/TVcMM6

CRISPRa-identified transcription factors reprogram glioblastoma into dendritic cell-like cells to...

Liu et al. demonstrate a cellular reprogramming strategy that directly transforms glioblastoma cells into functional dendritic cell-like cells. This in situ conversion remodels the tumor microenvir...

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Online now: Lysyl oxidase inhibition disrupts mitochondrial homeostasis to create vulnerability to ferroptosis in TNBC dlvr.it/TVblBt

Lysyl oxidase inhibition disrupts mitochondrial homeostasis to create vulnerability to ferroptosis...

Saatci-Ulukan et al. show that lysyl oxidase (LOX) has non-canonical intracellular functions in promoting glucose metabolism, inhibiting mitophagy, and sustaining redox homeostasis and that inhibit...

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Online now: Single-cell tracking reveals tumor-reactive T cell plasticity during melanoma TIL therapy dlvr.it/TVbVl3

Single-cell tracking reveals tumor-reactive T cell plasticity during melanoma TIL therapy

Sandholzer et al. track tumor-reactive T cells across TIL therapy in metastatic melanoma using single-cell RNA and TCR sequencing. They show how ex vivo expansion reshapes CD8+ and CD4+ T cell states...

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Online now: First-line fecal microbiota transplantation for the management of immune checkpoint inhibitor-mediated diarrhea and colitis dlvr.it/TVZvGy

First-line fecal microbiota transplantation for the management of immune checkpoint inhibitor-med...

Wang et al. report the efficacy of a preliminary cohort of patients who receive first-line fecal microbiota transplantation for the management of immune-mediated diarrhea and colitis with multi-omics...

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Online now: L013 promotes NRF2 degradation in NRFA-subtype esophageal squamous cell carcinoma dlvr.it/TVZcl5

L013 promotes NRF2 degradation in NRFA-subtype esophageal squamous cell carcinoma

Yu et al. identify L013 as an NRF2-targeting agent that reduces NRF2 via UPS-associated degradation and A51-mediated suppression. L013 inhibits tumor growth in preclinical models, revealing therape...

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Online now: Neutrophil elastase-mediated myoepithelial loss is a therapeutic vulnerability in ductal carcinoma in situ progression dlvr.it/TVZ78D

Neutrophil elastase-mediated myoepithelial loss is a therapeutic vulnerability in ductal carcinoma...

Transition from ductal carcinoma in situ (DCIS) to invasive breast cancer remains a key step in disease progression that is poorly understood. Taifour et al. show that neutrophil elastase disrupts...

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Online now: Bi-hourly plasma proteomics during the first 48 h of life in an African cohort reveals distinct periods and sex-dependent immune development dlvr.it/TVYxh5

Bi-hourly plasma proteomics during the first 48 h of life in an African cohort reveals distinct...

Bennike et al. profile plasma proteins and cytokines/chemokines in 679 healthy newborns through mass spectrometry and immunoassays to characterize immune adaptation during the 48 h immediately after...

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Online now: Targeted insertion of an optimized donor DNA is effective in a humanized mouse model of dominant retinitis pigmentosa dlvr.it/TVYbF0

Targeted insertion of an optimized donor DNA is effective in a humanized mouse model of dominant...

Esposito et al. develop a donor-optimized, mutation-agnostic AAV-HITI strategy for dominant rhodopsin-associated retinitis pigmentosa that simultaneously disrupts the mutant RHO P23H allele and...

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Online now: Intoxication and other subjective effects of preanesthetic opioids in surgical patients: A randomized controlled trial dlvr.it/TVYPgn

Intoxication and other subjective effects of preanesthetic opioids in surgical patients: A random...

Karlsen et al. show that patients experience marked undesirable effects but minimal desirable effects after preoperative intravenous opioids.

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