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Compound Researcher (@Compoundarxiv) profile picture

Compound Researcher

@Compoundarxiv

What we're researching @compoundvc | DM @mhdempsey @shelbynewsad @0xsmac @mackenziejem to discuss

Joined July 2020
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Our public theses
Michael Dempsey (@mhdempsey) profile pictureMichael Dempsey
@mhdempsey30 Nov 2022
Replying to @mhdempsey
Enter the Compound Thesis Database An experiment with a few of our working theses that we've pulled from our internal database & made public. It's rough, but we hope it allows founders, operators, & investors to better connect with us & help us learn. compound.vc/thesis
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ieeexplore.ieee.org/document…
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pubs.aip.org/aip/apm/article…
Diamond thermal matrix demonstration for two-tier 3D integrated circuits

Diamond thermal matrix demonstration for two-tier 3D integrated circuits

A diamond matrix scaffold is crucial for 3D dense chips because it provides exceptional thermal management due to its excellent thermal conductivity. Diamond ca

pubs.aip.org
126
arxiv.org/abs/2609.40209
Designing Strongly Correlated Quantum Phases of Matter with...

Designing Strongly Correlated Quantum Phases of Matter with...

Materials design is an inverse problem: finding the couplings of a microscopic Hamiltonian whose ground state exhibits a desired property. For strongly correlated quantum systems, this remains...

arxiv.org
205
nature.com/articles/s41586-0…
Random heteropolymers as enzyme mimics

Random heteropolymers as enzyme mimics

Nature - Modulation of random heteropolymers results in globular polymer clusters with catalytic activity mimicking proteins.

nature.com
217
biorxiv.org/content/10.64898…
Functional recovery of vitrified and nanowarmed human-scale pig kidneys

Functional recovery of vitrified and nanowarmed human-scale pig kidneys

Organ transplantation is critically constrained by the short preservation window for donor organs, limiting allocation and contributing to organ discard and waitlist mortality. Cryogenic organ...

biorxiv.org
211
osf.io/preprints/osf/ukfx3_v…
CO₂-to-food pathways via synthetic fat and H₂ microbial protein outperform alternatives on energy,...

CO₂-to-food pathways via synthetic fat and H₂ microbial protein outperform alternatives on energy,...

Power-to-food technologies could transform food systems by reducing CO₂, land, and water footprints while enhancing food security and global resilience. CO₂-to-food pathways span chemical synthesis...

osf.io
180
science.org/doi/10.1126/scie…
Wafer-scale ultrathin and uniform van der Waals ferroelectric oxide

Wafer-scale ultrathin and uniform van der Waals ferroelectric oxide

Ferroelectrics have great potential for nonvolatile memory and next-generation electronics, but conventional ferroelectric oxide films generally suffer structural nonuniformity, interfacial depolar...

science.org
182
arxiv.org/abs/2602.06036
DFlash: Block Diffusion for Flash Speculative Decoding

DFlash: Block Diffusion for Flash Speculative Decoding

Autoregressive large language models (LLMs) deliver strong performance but require inherently sequential decoding, leading to high inference latency and poor GPU utilization. Speculative decoding...

arxiv.org
168
biorxiv.org/content/10.64898…
Amplicon/Protein Bead Display enables quantitative in vitro biochemistry at scale

Amplicon/Protein Bead Display enables quantitative in vitro biochemistry at scale

Scalable methods for producing and characterizing protein libraries are essential for generating standardized datasets needed to train models linking sequence to function. Here, we present Amplicon...

biorxiv.org
182
nature.com/articles/s43588-0…
HIP: Hessian Interatomic Potentials without derivatives

HIP: Hessian Interatomic Potentials without derivatives

Nature Computational Science - The authors introduce an extension of machine learning interatomic potentials that predicts molecular Hessians directly, improving accuracy and speed compared in...

nature.com
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232
science.org/doi/10.1126/scie…
Magic state cultivation on a superconducting quantum processor

Magic state cultivation on a superconducting quantum processor

Fault-tolerant quantum computing requires a universal gate set, but the necessary non-Clifford gates represent a significant resource cost for most quantum error correction architectures. Magic state...

science.org
178
arxiv.org/abs/2604.07639
Exponential quantum advantage in processing massive classical data

Exponential quantum advantage in processing massive classical data

Broadly applicable quantum advantage, particularly in classical data processing and machine learning, has been a fundamental open problem. In this work, we prove that a small quantum computer of...

arxiv.org
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287
nature.com/articles/s41467-0…
A fully integrated smart ring for daily biochemical monitoring

A fully integrated smart ring for daily biochemical monitoring

Nature Communications - Commercial smart rings lack biochemical sensing. Here, the authors present a fully integrated ring that measures multiple chemical biomarkers from osmotically extracted...

nature.com
182
pmc.ncbi.nlm.nih.gov/article…
Protein abundance inference via expectation-maximization in fluorosequencing

Protein abundance inference via expectation-maximization in fluorosequencing

Fluorosequencing generates millions of single peptide reads, yet a principled route to quantitative protein abundances has been lacking. We present a probabilistic framework that adapts expectation...

pmc.ncbi.nlm.nih.gov
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215
biorxiv.org/content/10.64898…
Designing enzymes for new-to-nature chemistry and non-natural substrates with AlphaProtein Novo

Designing enzymes for new-to-nature chemistry and non-natural substrates with AlphaProtein Novo

Creating highly active enzymes for arbitrary reactions is a transformative goal for the molecular sciences[1][1]. Traditional protein engineering[2][2],[3][3] is constrained by a reliance on existing...

biorxiv.org
211
nature.com/articles/s41586-0…
Function-preserving watermarking of AI-generated proteins

Function-preserving watermarking of AI-generated proteins

Nature - SynthIDBio watermarks AI-generated protein sequences and structures while preserving function, enabling provenance detection and offering a proof-of-concept tool for biosecurity and...

nature.com
232
nature.com/articles/s41592-0…
Voltage imaging of neurons distributed across entire brains of larval zebrafish

Voltage imaging of neurons distributed across entire brains of larval zebrafish

Nature Methods - Voltage imaging across much of the zebrafish brain is achieved at 200.8 Hz, by optimizing a remote-scanning light-sheet microscope.

nature.com
207
thelancet.com/journals/laneu…
Dynamic changes in plasma biomarkers of Alzheimer's disease in patients treated with lecanemab: a...

Dynamic changes in plasma biomarkers of Alzheimer's disease in patients treated with lecanemab: a...

Lecanemab treatment was associated with dynamic, multidirectional changes across plasma biomarkers of Alzheimer's disease pathology, with partial normalisation of amyloid and tau biomarkers alongside...

thelancet.com
230
Compound Researcher retweeted
Mackenzie Morehead (@mackenziejem) profile picture
Mackenzie Morehead
@mackenziejemSep 23
Fantastic Research Day on sleep. Special thanks to all speakers!! Couple interesting insights: - ARPAH is funding the collection of a gigantic dataset on 100M EHR records to disentangle sleep's pathology. This will be massively helpful for tx translation efforts - With tx routes we like targeting AD/PD via SWS + glymphatic clearance a core issue pharma wants to see for trials is subtyping/patient selection - Habituation/homeostatic adjustment would also be a concern for even the best tx ideas To stay informed about these research days we host (like Shelby's next week on data), sign up here: compound-newsletter.vercel.a…
Image from Mackenzie Morehead (@mackenziejem)
Image from Mackenzie Morehead (@mackenziejem)
Image from Mackenzie Morehead (@mackenziejem)
Image from Mackenzie Morehead (@mackenziejem)
Mackenzie Morehead (@mackenziejem) profile pictureMackenzie Morehead
@mackenziejemSep 8
We just confirmed two new speakers! Stanford researcher on her mechanistic work on brain circuits that drive sleep regulation And UCSF epidemiologist on her evidence for the link between sleep & AD/PD You won't find more wisdom about sleep in one room luma.com/249fnmh6
Image from Mackenzie Morehead (@mackenziejem)
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biorxiv.org/content/10.64898…
Engineered Allosteric RNA Editors Enable Compact, Stimulus-Responsive Post-Transcriptional Circuits

Engineered Allosteric RNA Editors Enable Compact, Stimulus-Responsive Post-Transcriptional Circuits

Translational regulation offers a powerful biological control axis with the potential to enable programmable control over synthetic mRNAs. Here, we introduce inducible Deaminases Acting on RNA...

biorxiv.org
216
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