David Porciani (@DavePorciani) header
David Porciani (@DavePorciani) profile picture

David Porciani

@DavePorciani

Senior Staff Scientist, previously @SomaLogic, Assistant Research Professor @Mizzou @BurkeLabRNA, PhD @scuolanormale, #Aptamers #biomarkers #nanotech

 San Diego, CA
scholar.google.com/citations?user=hpubQEIAAAAJ&hl=en
Joined June 2014
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  • Following527
  • Followers581
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Photo by David Porciani (@DavePorciani)Photo by David Porciani (@DavePorciani)Photo by David Porciani (@DavePorciani)Photo by David Porciani (@DavePorciani)Photo by David Porciani (@DavePorciani)Photo by David Porciani (@DavePorciani)Photo by David Porciani (@DavePorciani)Photo by David Porciani (@DavePorciani)Photo by David Porciani (@DavePorciani)Photo by David Porciani (@DavePorciani)
Such a great experience and a pleasure to attend the annual mtg of the @OTSociety together with the brilliant @Brian (MD-PhD student I’m mentoring in the @BurkeLabRNA). Lots of awesome applications of #RNA #therapeutics and great discussions and networking… I needed this!
Image from David Porciani (@DavePorciani)
Image from David Porciani (@DavePorciani)
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David Porciani retweeted
Pietro Delcanale (@delca_p) profile picture
Pietro Delcanale@delca_p10 Jan 2024
💥Our new paper is officially out! A great collaboration with the aptamer master @DavePorciani. "Fluorescence Correlation Spectroscopy as a Versatile Method to Define Aptamer-Protein Interactions with Single-Molecule Sensitivity" pubs.acs.org/doi/10.1021/acs…

Fluorescence Correlation Spectroscopy as a Versatile Method to Define Aptamer–Protein Interactions...

Abstract. Aptamers are folded oligonucleotides that selectively recognize and bind a target and are consequently regarded as an emerging alternative to ant

pubs.acs.org
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Targeting lung cancer with clinically relevant EGFR mutations using anti-EGFR RNA aptamer #MTNA dlvr.it/Sx4hK6
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David Porciani retweeted
Chris Serpell (@CJSerpell) profile picture
Chris Serpell@CJSerpell23 Aug 2023
Here's @alexandrarosiee's magnum opus from her PhD now out in @ChemicalScience - chemical modifications improve aptamers, but how and where should you modify? We can tell you.... pubs.rsc.org/en/content/arti…
Selection of optimised ligands by fluorescence-activated bead sorting†

Selection of optimised ligands by fluorescence-activated bead sorting†

The chemistry of aptamers is largely limited to natural nucleotides, and although modifications of nucleic acids can enhance target aptamer affinity, there

pubs.rsc.org
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David Porciani retweeted
BurkeLab (@BurkeLabRNA) profile picture
BurkeLab@BurkeLabRNA12 Apr 2023
End of an era and passing the torch, as Brian takes over the anti-cancer aptamer work and David leaves @BondLifeSci @Mizzou for new challenges Bittersweet/awesome when good friends and long-time collaborators succeed and move on Watch out San Diego! @DavePorciani @bthomasZOU
Image from BurkeLab (@BurkeLabRNA)
Image from BurkeLab (@BurkeLabRNA)
Image from BurkeLab (@BurkeLabRNA)
Image from BurkeLab (@BurkeLabRNA)
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Our latest @n4nlab work is out! Understanding aptamer-functionalized nanoparticle multivalency and targeting. Great work of @wth_laura: now your PhD is all out! And as usual fantastic collaboration with our aptamer wizards @DHBurkeAguero @DavePorciani sciencedirect.com/science/ar…
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David Porciani retweeted
BurkeLab (@BurkeLabRNA) profile picture
BurkeLab@BurkeLabRNA4 Dec 2022
This week! @BurkeLabRNA alumn Kwaku Tawiah is the featured speaker at the Dec ACES event (Alternative Career Exploration in the Science). @LabMed_Guy
Image from BurkeLab (@BurkeLabRNA)
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David Porciani retweeted
Alex Taylor (@Taylor_Lab_KCL) profile picture
Alex Taylor@Taylor_Lab_KCL13 Oct 2022
🚨New paper in @NatureChemistry w/ @PhilHolliger joint 1st w/ brill saxophonist & bowtie fan @Niklas_Freund1 We describe a polymerase for efficient DNA-templated synthesis of 2’OMe- & MOE-RNA & develop biostable aptamers & RNA-cleaving 2’OMezymes #synbio nature.com/articles/s41557-0…
A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyet...

A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyet...

Nature Chemistry - Sterically demanding 2′-modified nucleotides used in antisense therapeutics have thus far been challenging to synthesise enzymatically. Now, it has been shown that mutation...

nature.com
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#OTS22 #aptamers #EGFR
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Very excited to join the McGill crew and get dinner together… a great start for this #ots22 @OTSociety
Aurélie Lacroix (@AurelieLacroix_) profile pictureAurélie Lacroix@AurelieLacroix_2 Oct 2022
Happy to meet again face to face with Montréal crew (and more) 😁. (And hello to @SleimanHanadi & @F_ANAtico 😁) 🙈☺️
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Happy to meet again face to face with Montréal crew (and more) 😁. (And hello to @SleimanHanadi & @F_ANAtico 😁) 🙈☺️
Leonora Abdullahu (@Leonora_Abd) profile pictureLeonora Abdullahu@Leonora_Abd2 Oct 2022
A little @uMcGill reunion tonight on OTS-eve! And meeting new friends! Ready for day one of #OTSPhoenix tomorrow.
Image from Leonora Abdullahu (@Leonora_Abd)
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If you have a minute (I promise it's that quick) - help us out @StemloopInc and take this survey!
Stemloop, Inc. (@StemloopInc) profile pictureStemloop, Inc.@StemloopInc6 Sep 2022
We're all familiar with Lateral Flow Tests after Covid-19, but reading them can be a challenge (is that a line or a smudge?!). We've decided to put Stemloop's supporters to the test w/ this quick, 1 min survey. Your response is appreciated! forms.office.com/Pages/Respo…
Screenshot of Stemloop Band Visibility Survey

ALT Screenshot of Stemloop Band Visibility Survey

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Yeah 🎉 I know how hard you have worked to achieve this result, I’m very proud of you 👏🏼 #WomenInSTEM #workingmama
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Just submitted my abstract to be considered for short talk at the next #oligonucleotide mtg #OTS2022 @OTSociety I’m very excited to attend this in-person conference after 2+ yrs and share my latest developments in #aptamer research & #tumor targeting #EGFR #NSCLC @BurkeLabRNA
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David Porciani retweeted
Alex Taylor (@Taylor_Lab_KCL) profile picture
Alex Taylor@Taylor_Lab_KCL18 Jul 2022
I’ve published a ‘Matters Arising’ article in @NatureChemistry in collab with @PhilHolliger in which we examine a modified version of the 10-23 DNAzyme, “X10-23”, described by the labs of Profs. John Chaput and Robert Spitale (UC Irvine) – A thread (1/10) nature.com/articles/s41557-0…
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The final version of the article by the #Aptamer Consortium entitled "The minimum aptamer publication standards (MAPS guidelines) for de novo aptamer selection" in #JAptamers can be read on the following link: japtamers.co.uk/the-minimum-… @aptamer_connect @mmckeague
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"The minimum aptamer publication standards (MAPS guidelines) for de novo aptamer selection" is now out in Aptamers @JAptamers Thanks to Maureen and Sarah for taking the lead to get this written and published. japtamers.co.uk/the-minimum-…
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A new landmark article by the #Aptamer Consortium entitled "The minimum aptamer publication standards (MAPS guidelines) for de novo aptamer selection" in #JAptamers: In-press, unedited version can be read on the following link: japtamers.co.uk/the-minimum-… @aptamer_connect @mmckeague
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After two years, the ALMC Image Contest is back with striking photos on display at Bond LSC stopping passerby students in their tracks. Find out how winning researchers Christie Herd, @DavePorciani and @JanloRobil approach their work: 🔗decodingscience.missouri.edu… #MizzouResearch
Image from Mizzou Life Sci Center (@BondLifeSci)
Image from Mizzou Life Sci Center (@BondLifeSci)
Image from Mizzou Life Sci Center (@BondLifeSci)
Image from Mizzou Life Sci Center (@BondLifeSci)
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Assistant Research Prof. @DavePorciani (right) uses aptamer technology to improve targeting of anti-cancer reagents. New post-doc, Georg Pietruschka (left), will explore Origins of Life with @NASA. Today they ponder recently collected data together. #TuesdayTakeover @BondLifeSci
Image from Mizzou Life Sci Center (@BondLifeSci)
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