Luca Delfinis, PhD retweeted
The term mitochondrial dysfunction is often misnomer
Something that looks “dysfunctional” with a single approach can end up being an adaptive recalibration when seen more holistically with multiple measures
Excellent paper below by @ChrisPerryMito
When is a change in mitochondrial bioenergetics reflective of 'mitochondrial dysfunction' vs 'intentional reprogramming'?
Here we present traditional vs alternative interpretations of mitochondrial responses to muscle disuse.
physoc.onlinelibrary.wiley.c…
Luca Delfinis, PhD retweeted
When is a change in mitochondrial bioenergetics reflective of 'mitochondrial dysfunction' vs 'intentional reprogramming'?
Here we present traditional vs alternative interpretations of mitochondrial responses to muscle disuse.
physoc.onlinelibrary.wiley.c…
Luca Delfinis, PhD retweeted
Published research from recent #YorkU Kinesiology & Health Science @YorkUKINE PhD grad Luca Delfinis is the first to show muscle weakness precedes muscle wasting in cancer – a groundbreaking discovery for early detection & treatment. tinyurl.com/533x3prn
ALT York Kinesiology and Health Science PhD graduate Luca Delfinis
Luca Delfinis, PhD retweeted
Our 3rd new manuscript this week: @DelfinisLuca found a mitochondrial-targeted compound partially prevents muscle weakness without preventing atrophy in ovarian cancer. This opens a new direction for therapies targeting muscle ‘quality’. biorxiv.org/content/10.1101/…
Luca Delfinis, PhD retweeted
Seeing these two convocate at the same time was a special experience for me. Shahrzad Khajehzadehshoushtar @shardarabi_, MSc, and Luca Delfinis @DelfinisLuca, PhD. This duo poured their passion into a huge shared project on ovarian cancer-induced cachexia. Onward and upwards!
Luca Delfinis, PhD retweeted
Congrats to Shahrzad Khajehzadehshoushtar @SharShoush for an outstanding MSc defence! Shar is nominated for a thesis prize for a carefully crafted document, voluminous work, + high-level discussion
Watch for Shar's publication on mitochondrial therapy in ovarian cancer cachexia
Luca Delfinis, PhD retweeted
We are proud to introduce Dr. Luca Delfinis, who has successfully defended his PhD! As a doctoral student in @ChrisPerryMito's lab, Luca studied the links between metabolic dysfunction & cancer cachexia to advance a treatment for this illness. Many congratulations, Luca! 👏#YorkU
Very proud to announce the newly minted Dr. Luca Delfinis! @DelfinisLuca will have a fantastic career and be respected by his peers, as he is/was here in @YorkUHealth. He will be missed but watch out for his next big steps in industry.
Luca Delfinis, PhD retweeted
Here are Luca's published first author papers. His last paper is about to be submitted!
Muscle weakness precedes atrophy during...
Ovarian cancer cachexia: pubmed.ncbi.nlm.nih.gov/3892…
C26 colorectal cancer: pubmed.ncbi.nlm.nih.gov/3634…
Luca Delfinis, PhD retweeted
Very proud to announce the newly minted Dr. Luca Delfinis! @DelfinisLuca will have a fantastic career and be respected by his peers, as he is/was here in @YorkUHealth. He will be missed but watch out for his next big steps in industry.
Luca Delfinis, PhD retweeted
@MHRC_YorkU we need to all congratulate Luca on his exceptional #PhD defence under the outstanding mentorship of prof @ChrisPerryMito #cancer #muscle @YorkUniversity
Luca Delfinis, PhD retweeted
Women with metastatic ovarian cancer experience severe muscle wasting
Here, @DelfinisLuca in our lab describes a new mouse model to help study this relationship
We also found that weakness actually precedes metastasis and atrophy
@MolMetab is fast! 1/
sciencedirect.com/science/ar…
Luca Delfinis, PhD retweeted
Women with advanced ovarian cancer experience severe muscle wasting once metastasis occurs
Here, we describe a new mouse model of metastatic ovarian cancer cachexia that can be used to study this relationship
We also found that weakness actually precedes metastasis and atrophy
Muscle weakness and mitochondrial stress occur before metastasis in a novel mouse model of ovarian cancer cachexia biorxiv.org/cgi/content/shor… #bioRxiv
Luca Delfinis, PhD retweeted
For cancer patients, maintaining muscle is vital to health and treatment, but staying strong is complicated theconversation.com/for-canc… via @ConversationCA
Luca Delfinis, PhD retweeted
The @CancerCachexia Society Education Committee invites you to the fourth of our Trainee Talks on November 8th at 12:00 pm EST!
Selected speakers: Deena Snoke, Luca Delfinis and Andrea Irazoki.
Seminars are open to everyone, please share!
See cancercachexiasociety.org for link!
Luca Delfinis, PhD retweeted
Cancer cachexia is a muscle wasting syndrome that is associated with certain cancers. Research characterizing the multifactorial origins of this syndrome is still ongoing. Check out 3 recent publications that have made notable advances in this pub review: bit.ly/4925ces
🧵The NotedSource Physiology Research Community is an exclusive platform for academics to share articles, discussion topics and funding/job opportunities with fellow experts. The focus of this community is to integrate the complexity of physiology..
..in the context of health science with application to human disease. This is an excellent space to join to stay up to date on the most recent data and directions in physiology!
Create an account and apply to join the community through the following link:
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Presenting our recently published work on behalf of @ChrisPerryMito in the 16th annual SCWD conference at the Karolinska Institute. What an amazing experience surrounded by an exceptional group of researchers! @SCWDnews @JCSM_cachexia
Luca Delfinis, PhD retweeted
Very happy to announce that Luca Delfinis @DelfinisLuca in our lab will present his work next to leaders in cancer cachexia in Stockholm. Luca found 1) cancer causes weakness and mitochondrial stress before atrophy, 2) some muscles restore specific force!
society-scwd.org/annual-conf…
