Full Professor in Pharmacology @pharma_UPSaclay, @UnivParisSaclay, @moods_inserm, @cesp_inserm visiting Professor @columbiaPsy Study psychiatric disorders
France
Joined July 2016
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Really to be part of this story with @DrChristineAnnD and @BriKChen
Featured on the cover of Biological Psychiatry: Research from Dr. Briana Chen in @DrChristineAnnD's lab shows that a single combined dose of (R,S)-ketamine and prucalopride outperforms single-drug treatments against stress. Read the full study: biologicalpsychiatryjournal.…
Our findings suggest that targeting the 5-HT4 recepto may open new perspectives for faster-acting antidepressant strategies and improved patient care.
#depression #antidepressant #newtherapy #repurposing
This study highlights the potential repositioning of #prucalopride, a medication currently prescribed for chronic constipation, as a promising candidate for the treatment of #depression and #anxiety.
This study highlights the potential repositioning of #prucalopride, a medication currently prescribed for chronic constipation, as a promising candidate for the treatment of #depression and #anxiety.
Our latest paper is avàaible online « Prucalopride, a serotonin type 4 receptor agonist, induces fast anxiolytic/antidepressant effects and concomitant changes in the gut microbiota » | npj Biofilms and Microbiomes
rdcu.be/e3ylX nature.com/articles/s41522-0…
Our latest paper is avàaible online « Prucalopride, a serotonin type 4 receptor agonist, induces fast anxiolytic/antidepressant effects and concomitant changes in the gut microbiota » | npj Biofilms and Microbiomes
rdcu.be/e3ylX nature.com/articles/s41522-0…
Denis DAVID retweeted
Wrapping up 👋🏽 another amazing experience #ACNP2026 @ACNPorg 🇧🇸 #Goodscience #meetings #networking. Great to catch up #friends #colleagues #newconnections to discuss/share science 💊🧬🧠. Wonderful family environment 😍👏🏽👍 Congrats to all the awardees 👏🏽 ready for #ACNP2027 😉
Do not miss our latest work @ACNPorg
If you’ve some free time stop by and say hi 👋🏽😉 Let’s talk about #5ht4R #Prucalopride #anxiolytic #newtreatmetns 🧠💊 Amazing collaboration wonderful people 😉@DrChristineAnnD @DenisJDavid @CorrubleE @MOODS_Inserm @UnivParisSaclay @Columbia @ACNPorg #ACNP2026
#ACNP2026 🇧🇸🤓😎
Denis DAVID retweeted
If you’ve some free time stop by and say hi 👋🏽😉 Let’s talk about #5ht4R #Prucalopride #anxiolytic #newtreatmetns 🧠💊 Amazing collaboration wonderful people 😉@DrChristineAnnD @DenisJDavid @CorrubleE @MOODS_Inserm @UnivParisSaclay @Columbia @ACNPorg #ACNP2026
#ACNP2026 🇧🇸🤓😎
Our latest paper is online
Leveraging Fiber Photometry to Decipher Neural Circuits Underlying Anxiety in Mice - Abdennebi - 2025 - Fundamental & Clinical Pharmacology - Wiley Online Library onlinelibrary.wiley.com/doi/…
Great collaboration between @DrChristineAnnD and @BriKChen @ColumbiaPsych and @MOODS_Inserm
Co-administration of prucalopride, a 5HT4R agonist, and ketamine has extended benefits for combating stress-induced pathophysiology
#ThisWeekInNPP
@DrChristineAnnD & @BriKChen show that chronic co-admin of ketamine+5HT4 agonist prucalopride exerts therapeutic effects in🐭models of stress
@AliciaWhye @tayyymoniz @im74ve @DenisJDavid @alain_gardier @Stef_JohnsPhD @SiloPharma
nature.com/articles/s41386-0…
Denis DAVID retweeted
Scientific mission accomplished Represented @MOODS_Inserm
@ParisSaclay 🤓 Always a pleasure to get together 🤗meet friends/colleagues & welcome new people that are doing #AmazingScience #MoodDisorders Thanks for the symposium acceptance @SOBP ☺️🤗see you all 🇺🇸 #NYC #SOBP2026 😉
Congrats Indira @MOODS_Inserm for this fantastic talk #sobp2025 @SOBP on the role of #serotonin type 4 receptor in anxiety and depression @MOODS_Inserm
Fantastic panel 👏👏👏5HT4 symposium! Interactive audience and a great session 🤓Thank you all for your support 🤗😉 looking forward for more special moments! #Science #SOBP2025 Great collaborations and more to come @BriKChen @DrChristineAnnD @MOODS_Inserm 🧠🤓
Don’t miss @im74ve presentation tomorrow @SOBP #SOBP2025 on the role of the 5HT4 receptor to treat anxiety and depression @MOODS_Inserm
Denis DAVID retweeted
Ready for the scientific aventure!! 🤓 #SOBP2025
Welcome to Toronto! The #SOBP2025 Annual Meeting is officially underway! Over the next three days, we’ll explore how AI is transforming psychiatric research and practice. Stay tuned for key insights and highlights! 💡 #ArtificialIntelligence #MentalHealthResearch
Indira will be presenting her latest data on 5HT4 and anxiety @MOODS_Inserm
Hello everyone 👋🏽On my way and excited to meet with colleagues and friends and of course to participate on my first symposium! Stay tuned for more details⚠️ #SOBP2025 #Toronto 🇨🇦 this week! sobp.societyconference.com 😉
À ne pas manquer👇
Symposium "Le sport, bien plus qu’une activité physique" avec l'@UnivParisSaclay.
📅 Jeudi 27 mars - 19h
📍 Maison des Arts, Le Plessis-Robinson
Experts et athlètes échangeront sur les liens entre sport et santé mentale.
📄⬇️Communiqué de presse
#SportEtSanté #PlessisRobinson
La Faculté de Pharmacie de l’UPSaclay et la mairie du Plessis-Robinson vous invitent au prochain symposium sur la Santé Mentale.
🗓 Le sport, bien plus qu’une activité physique
📅 jeudi 27 mars 2025 - 19h
📲 Inscription obligatoire ➡️ admin-sphinx.universite-pari…
@MOODS_Inserm
The best team
Another annual scientific seminar overseas #Martinique 🇲🇶 total success sharing with colleagues & friends #scientificprojects #Futurecollaborations 🧑🏽🔬👨🔬👨🏼💻💊🧠 in a wonderful place 🏝️😎😉 looking forward for another exciting year 😉@MOODS_Inserm @UnivParisSaclay @Pharma_UPSaclay
Our latest paper, a collaboration betEen @MOODS_Inserm and @SHFJ_cea Synaptic Vesicle 2A (SV2A) Positron Emission Tomography (PET) Imaging as a Marker of Therapeutic Response in a Mouse Model of Depression | ACS Pharmacology & Translational Science pubs.acs.org/doi/full/10.102…
