Assistant Prof @CityUHongKong | Bone-Kidney Axis & Regeneration | FGF23-Klotho | Veterinarian-Scientist ๐งฌ๐ฌ | Vet Education
Hong Kong, SAR
Joined July 2022
- Tweets60
- Following70
- Followers76
- Likes4.7K
Pinned Tweet
Antiaging, Klotho, kidney or mineral metabolism interests you? ๐๐งต
After 5+ years of work, weโre excited to share our research just published in Kidney Int. It dissects nephron segment-specific roles of Klotho in the kidney. @Kidney_Int @ISNkidneycare @CityUHongKong @UZH_en
An excellent opportunity to join our Bone-Kidney Axis and Regeneration Lab at CityUHK through the interdisciplinary PhD Programme in Veterinary Medicine (VM/P), in collaboration with Cornell University!
More about our research: cityu.edu.hk/ph/staff/prof-gโฆ
Our new study is just published! We identified an association in >300 people, then followed up in mice and cells. Our findings point to a new potential hormonal cascade whereby high salt intake increases cortisol, which may suppress FGF23.
Link: doi.org/10.1007/s00424-026-0โฆ
CKD and the aging-like phenotype may be driven by proximal rather than distal nephron Klotho dysregulation.
Invited mini-review: Klotho Revisited: Tubular Heterogeneity Reshapes Mineral Metabolism, Aging, and CKD
link.springer.com/article/10โฆ
Thank you to @CityUHongKong for showcasing our recent research on Klotho biology. It's a pleasure to see our work reach a wider audience.
Klotho, the "longevity protein," has long been a black box โ we knew kidneys produced it, but not how it worked. #CityUHK Professor Ganesh Pathare, in collaboration with Professor Johannes Loffing, from the University of Zurich, have finally mapped its precise kidney functions - cracking the code! ๐
Two game-changing discoveries:
๐ Distal tubule Klotho โ regulates calcium & bone health
๐ Proximal tubule Klotho โ maintains phosphate & circulating sKlotho levels
Overturning long-held assumptions, this study opens new doors for treating chronic kidney disease! ๐ฉบ
๐ Read more: go.cityu.hk/tlivyt
3
69
Open postdoc position in our group!!
More about our research: cityu.edu.hk/ph/staff/prof-gโฆ. Interested candidates can contact: [email protected]. Please share with anyone who might be interested.
High-salt diet modulates endocrine regulation between cortisol and FGF23 biorxiv.org/content/10.1101/โฆ
3
155
Excited to start as ๐๐ฌ๐ฌ๐ข๐ฌ๐ญ. ๐๐ซ๐จ๐ at CityU HK๐
Building a ๐ญ๐ซ๐๐ง๐ฌ๐ฅ๐๐ญ๐ข๐จ๐ง๐๐ฅ ๐ซ๐๐ฌ๐๐๐ซ๐๐ก ๐ฉ๐ซ๐จ๐ ๐ซ๐๐ฆ on the boneโkidney axis ๐งฌ
๐๐ก๐ ๐๐ฉ๐ฉ๐ฅ๐ข๐๐๐ญ๐ข๐จ๐ง๐ฌ open AugโSep ๐
HK = ๐ฏ๐ข๐๐ซ๐๐ง๐ญ ๐๐ข๐ญ๐ฒ + ๐ฉ๐๐๐๐๐๐ฎ๐ฅ ๐ก๐ข๐ค๐๐ฌ in nature๐ฟ๐
1
3
136
Gene therapy targeting sustained FGF23-ERK signaling alleviates kidney inflammation biorxiv.org/content/10.1101/โฆ
3
171
๐๐
๐ฐ๐ถ๐๐ฒ๐ฑ to share our latest on ๐๐น๐ผ๐๐ต๐ผ & ๐๐๐๐ฎ๐ฏ ๐๐ถ๐ด๐ป๐ฎ๐น๐ถ๐ป๐ด and honored to give an ๐ถ๐ป๐๐ถ๐๐ฒ๐ฑ ๐๐ฎ๐น๐ธ at ๐๐ฅ๐ ๐ฎ๐ฌ๐ฎ๐ฑ ๐ถ๐ป ๐ง๐๐๐ฐ๐ฎ๐ป๐! ๐ Huge thanks to the organizers! Looking forward to discusions & catching up with colleagues!
4
153
Please take a look at our latest work on FGF23 regulation, recently published in JBC.
jbc.org/article/S0021-9258(2โฆ
Thread:๐งต
Our manuscript posted in bioRxiv (not peer reviewed yet): Sodium levels have a direct impact on FGF23 production! Tonicity and NFAT5 play an important role.
"Extracellular sodium regulates fibroblast growth factor 23 (FGF23) formation. biorxiv.org/content/10.1101/โฆ
