Erik Toraason (@EToraason) header
Erik Toraason (@EToraason) profile picture

Erik Toraason

@EToraason

Postdoc @ctmurphy1 lab, Princeton University | LSRF Fellow @LSRFdtn @sfariorg | Aging and DNA repair in C. elegans

 Princeton, NJ
Joined June 2019
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Photo by Erik Toraason (@EToraason)Photo by Erik Toraason (@EToraason)Photo by Erik Toraason (@EToraason)
Structural duality enables a single protein to act as a toxin–antidote pair for meiotic drive | PNAS pnas.org/doi/abs/10.1073/pna… & A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring | PNAS pnas.org/doi/abs/10.1073/pna… 2 amazing papers! 🤩
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At the end of 2018 I was lucky to receive a @cziscience Ben Barres award. This preprint is the culmination of that funding, which allowed us to try "out of the box" ideas to study neurodegeneration. Fearlessly led by amazing student @MitaliTyagi2! 🧵 /1 biorxiv.org/content/10.1101/…
Arc mediates intercellular tau transmission via extracellular vesicles

Arc mediates intercellular tau transmission via extracellular vesicles

Intracellular neurofibrillary tangles that consist of misfolded tau protein[1][1] cause neurodegeneration in Alzheimer’s disease (AD) and frontotemporal dementia (FTD). Tau pathology spreads cell-t...

biorxiv.org
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Schuh Lab (@SchuhLab) profile picture
Schuh Lab@SchuhLab21 Oct 2024
Women lose >90% of their #eggs by their mid-30s, with persistent #DNADamage driving this loss. But why isn’t this damage repaired? Our new work in @CurrentBiology, led by @ninadini_sharma, reveals the causes of high DNA damage in aged oocytes.🧬💥 bit.ly/48e35Ee (1/13)
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The Nobel Prize (@NobelPrize) profile picture
The Nobel Prize
@NobelPrize7 Oct 2024
This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans. Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals, making it a useful model for investigating how tissues develop and mature in multicellular organisms. Read how the 2024 medicine laureates’ investigations into C. elegans revealed an entirely new dimension to gene regulation: bit.ly/4dlPE6f #NobelPrize
Image from The Nobel Prize (@NobelPrize)
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The Nobel Prize (@NobelPrize) profile picture
The Nobel Prize
@NobelPrize7 Oct 2024
BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.
Image from The Nobel Prize (@NobelPrize)
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Brunet Lab (@BrunetLab) profile picture
Brunet Lab@BrunetLab3 Oct 2024
Can we use CRISPR screens to identify genes that drive neural stem cell aging? Super excited to see this work published @Nature! Huge congrats to Tyson @ruetz_tyson, Angie Pogson, @kashiwagi_chloe, and all authors! Great collaboration with @MCBassik! nature.com/articles/s41586-0…
CRISPR–Cas9 screens reveal regulators of ageing in neural stem cells

CRISPR–Cas9 screens reveal regulators of ageing in neural stem cells

Nature - CRISPR–Cas9 screens in cultures of young and old neural stem cells (NSCs) and in vivo in old mice identify gene knockouts that can boost old NSC activation and neurogenesis, with...

nature.com
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yeast_papers (@yeast_papers) profile picture
yeast_papers@yeast_papers15 Sep 2024
BioRxiv: Synaptonemal complex protects double-Holliday junctions during meiosis dlvr.it/TDGpHH
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Cejka Lab (@CejkaLab) profile picture
Cejka Lab@CejkaLab11 Sep 2024
We are thrilled to present you our work on BRCA1-BARD1 @Nature showing that the complex has a direct role in long-range DNA end resection. With @CeppiIlaria @DelloStritto_MR and our collaborators @PabloHuertasLab @SylvieNoorderm1 and Seidel labs. nature.com/articles/s41586-0…
Image from Cejka Lab (@CejkaLab)
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When I started my postdoc, I asked if partial reprogramming could rejuvenate aging worm neurons. It turns out, these worm OSK factors are neutral or even deleterious to C. elegans lifespan and chemosensation! Thanks to @ctmurphy1 and @RKaletsky for their help and support!
microPublication (@Micropub7n) profile picturemicroPublication@Micropub7n29 Aug 2024
In vivo neuron-specific expression of C. elegans reprogramming factor orthologs does not alleviate age-related cognitive decline #micropublication #biology #data #caltechlibrary #Celegans #PhenotypeData #NewFinding #NegativeResult micropublication.org/journal…
Image from microPublication (@Micropub7n)
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Our new paper is out @Nature We report that fibrin drives toxic inflammation, impaired viral clearance & neuropathology in #SARSCoV2 infection treated by #fibrin antibody #LongCovid #Coagulation #Immunotherapy #fibrinogen #COVID19 nature.com/articles/s41586-0…
Image from Katerina Akassoglou (@AkassoglouLab)
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We created a comic book based on our research on the role of GJ channels and bioelectricity in neuromuscular development! This was an amazing collaboration with undergraduate art student Bentley Smallwood.🐟🔬⚡️ Read the whole version here: opentext.uoregon.edu/science… #Zebrafish
Image from Rachel Lukowicz-Bedford, PhD (@RachelLukowicz)
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The last of my graduate work with @DianaLibuda is out in @eLife! We show that BRCA1 and SMC-5/6 regulate DNA break repair pathway engagement in C. elegans meiosis, but are not required for intersister repair. A fun "crossover" collab with @TheRogLab! elifesciences.org/articles/8…
BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis

BRCA1/BRC-1 and SMC-5/6 regulate DNA repair pathway engagement during Caenorhabditis elegans meiosis

To maintain genomic integrity during oocyte development, the tumor suppressor BRCA1/BRC-1 and the SMC-5/6 complex both repress intersister crossover recombination events while BRCA1/BRC-1 also...

elifesciences.org
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So honored to be selected as an LSRF @LSRFdtn fellow supported by @SFARIorg . Thank you to the amazing @ctmurphy1 for her insight and guidance as I've started new projects in the lab, and to all my mentors (especially @DianaLibuda) who have believed in me! lsrf.org/current-fellows/
Current Fellows - Life Sciences Research Foundation

Current Fellows - Life Sciences Research Foundation

lsrf.org
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Now in @CurrentBiology , we show that gap junction-mediated bioelectric signaling is required for the development and function of slow muscle. cell.com/current-biology/abs…
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RESEARCH | @ChenLesnik, @RKaletsky, @ctmurphy1 et al. (@Princeton): In C. elegans, branched-chain amino acid catabolism is important for maintaining oocyte quality with age 🪱 nature.com/articles/s42255-0…
Enhanced branched-chain amino acid metabolism improves age-related reproduction in C. elegans

Enhanced branched-chain amino acid metabolism improves age-related reproduction in C. elegans

Nature Metabolism - Lesnik, Kaletsky et al. show that in C. elegans branched-chain amino acid catabolism is important for maintaining oocyte quality with age.

nature.com
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Itamar Harel (@ItamarHarel) profile picture
Itamar Harel@ItamarHarel15 May 2024
The ultimate sacrifice? 🔥Amazing work @NatureAging by Tehila and Eitan, demonstrating that the germline regulates vertebrate longevity and somatic repair! A fun collaboration with @SagivShifman, @WJGreenleaf, Oren Ram & Ehud Cohen! Follow & retweet!! nature.com/articles/s43587-0…
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🔥🔥🔥my 💯 paper is out, congrats 🎈🎉🍾 @Meyer_DH for this amazing story. Aging clocks tick by the noise: we can build aging clocks 🕰️ on accumulating stochastic variation! @CECAD_ @UniCologne @CGA_age @UKKoeln follow 🧵retweet & read now open access: nature.com/articles/s43587-0…
Aging clocks based on accumulating stochastic variation

Aging clocks based on accumulating stochastic variation

Nature Aging - Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive...

nature.com
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Hank Green (@hankgreen) profile picture
Hank Green
@hankgreen27 Apr 2024
Can we...just accept that we suck at this? I want to tell you a story that has made me kinda hopeless about Twitter's ability to affect positive things happening, and it starts with this tweet from Hillary Clinton. nitter.cf/HillaryClinton/status/…
Hillary Clinton (@HillaryClinton) profile pictureHillary Clinton
@HillaryClinton22 Apr 2024
What's at stake for our climate in this November's elections? Absolutely everything. carbonbrief.org/analysis-tru…
Image from Hillary Clinton (@HillaryClinton)
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Congratulations🥂, too, to Coleen Murphy, Professor of Molecular Biology and the Lewis-Sigler Institute (LSI) for Integrative Genomics and Director, LSI, on her election into the 2023 class of #AAASFellows in the section on biological sciences! The Murphy lab studies aging👵👴.
Coleen Murphy, James A. Elkins Jr. Professor in the Life Sciences; Professor of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics; Director, Lewis-Sigler Institute for Integrative Genomics; AND Director of the Paul F. Glenn Laboratories for Aging Research at Princeton University!

ALT Coleen Murphy, James A. Elkins Jr. Professor in the Life Sciences; Professor of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics; Director, Lewis-Sigler Institute for Integrative Genomics; AND Director of the Paul F. Glenn Laboratories for Aging Research at Princeton University!

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Yifei Weng (@Yifei83155584) profile picture
Yifei Weng@Yifei831555845 Apr 2024
My first first-author paper is now on @elife: The Neuron-specific IIS/FOXO Transcriptome in Aged Animals Reveals Regulatory Mechanisms of Cognitive Aging doi.org/10.7554/eLife.95621.… Yay!
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