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eLife - the journal

@eLife

The funder-researcher collaboration and open-access journal for research in the life and biomedical sciences | @eLifeCommunity

 Cambridge, UK
elifesciences.org
Joined September 2011
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JAK-STAT pathway heterogeneity governs immunotherapy response in breast cancer elifesciences.org/articles/1…
JAK-STAT pathway heterogeneity governs immunotherapy response in breast cancer

JAK-STAT pathway heterogeneity governs immunotherapy response in breast cancer

Multi-omics investigation identifies cell-type JAK-STAT heterogeneity as a predictive biomarker for PD-1 blockade in breast cancer.

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Anatomy and mechanics of tsetse fly blood feeding elifesciences.org/articles/1…
Anatomy and mechanics of tsetse fly blood feeding

Anatomy and mechanics of tsetse fly blood feeding

A saw-like proboscis, forceful pulling movements, and precise targeting of softer skin sites allow tsetse flies to draw blood from remarkably diverse vertebrate hosts.

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Synaptic vesicle undocking induces low-frequency depression elifesciences.org/articles/1…
Synaptic vesicle undocking induces low-frequency depression

Synaptic vesicle undocking induces low-frequency depression

Low-frequency depression, an understudied form of synaptic plasticity, is proposed to reflect a reorganization of synaptic vesicles inside the readily releasable pool.

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Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic activity elifesciences.org/articles/1…
Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic...

Product-stabilized filamentation by human glutamine synthetase allosterically tunes metabolic...

Glutamine drives its own synthetase to assemble into inhibitory filaments, linking product concentration directly to a conformational switch that gates the active site.

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Synaptic connectome of a neurosecretory network in the Drosophila brain elifesciences.org/articles/1…
Synaptic connectome of a neurosecretory network in the Drosophila brain

Synaptic connectome of a neurosecretory network in the Drosophila brain

Connectome-level analysis of the Drosophila neuroendocrine system reveals the organizational logic by which the brain integrates sensory information to regulate hormonal signaling.

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Large-scale prospective evaluation of co-folding across hundreds of Mac1–ligand complexes and three virtual screens elifesciences.org/articles/1…
Large-scale prospective evaluation of co-folding across hundreds of Mac1–ligand complexes and three...

Large-scale prospective evaluation of co-folding across hundreds of Mac1–ligand complexes and three...

Co-folding methods accurately place and rank ligands within an optimization series, yet fail to separate true binders from docking false positives, suggesting complementary roles in drug discovery.

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Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development elifesciences.org/articles/1…
Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development

Svep1 orchestrates distal airway patterning and alveolar differentiation in murine lung development

Genetic and functional analyses identify SVEP1 as an extracellular matrix regulator that coordinates airway branching, smooth muscle differentiation, and alveolar maturation during lung development.

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Robust and replicable effects of ageing on resting-state brain electrophysiology measured with MEG elifesciences.org/articles/1…
Robust and replicable effects of ageing on resting-state brain electrophysiology measured with MEG

Robust and replicable effects of ageing on resting-state brain electrophysiology measured with MEG

Resting-state MEG reveals a replicable, full-frequency profile of ageing that offers a foundation for comparing and validating brain health biomarkers although detecting specific effects requires...

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Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic sites in human cells elifesciences.org/articles/1…
Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic...

Genome-wide mapping of Cas9-induced sister chromatid exchange across single and over 200 genomic...

Sci-L3-Strand-seq uncovers sister chromatid exchange as a frequent hidden outcome of Cas9-induced breaks, revealing genome-editing consequences that are invisible to conventional sequencing, and can...

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Obtaining maximum information from colony counts with REPOP elifesciences.org/articles/1…
Obtaining maximum information from colony counts with REPOP

Obtaining maximum information from colony counts with REPOP

Conventional colony counting obscures bacterial population structure by conflating biological heterogeneity with stochastic noise from dilution and plating, which can be separated by explicitly...

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📅 We're exhibiting at #SfN26 next week! Visit us at stand 2622 to chat about our publishing model and pick up some exclusive eLife goodies. See you in Washington, D.C.! @SfNtweets elifesciences.org/events/d27…
visit our booth at neuroscience 2026, we'll be at stand 2622

ALT visit our booth at neuroscience 2026, we'll be at stand 2622

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Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers elifesciences.org/articles/1…
Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

Punctuated mutagenesis promotes multi-step evolutionary adaptation in human cancers

Evolutionary modeling reveals that punctuated bursts of mutations facilitate fitness-valley crossing in cancer, promoting multi-step adaptation across complex fitness landscapes.

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A membrane-disruptive action of VBIT-4 challenges its role as a widely used VDAC1 oligomerization inhibitor elifesciences.org/articles/1…
A membrane-disruptive action of VBIT-4 challenges its role as a widely used VDAC1 oligomerization...

A membrane-disruptive action of VBIT-4 challenges its role as a widely used VDAC1 oligomerization...

VBIT-4 perturbs lipid membranes without detectably affecting VDAC1 channels or oligomerization, calling for careful interpretation of its biological effects and highlighting the need to assess...

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Role of desolvation on biomolecular liquid–liquid phase separation elifesciences.org/articles/1…
Role of desolvation on biomolecular liquid–liquid phase separation

Role of desolvation on biomolecular liquid–liquid phase separation

A desolvation-aware coarse-grained framework enables efficient and physically realistic modeling of biomolecular phase separation by capturing water-mediated effects on phase behavior, dense-phase...

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The structural context of mutations in proteins predicts their effect on antibiotic resistance elifesciences.org/articles/1…
The structural context of mutations in proteins predicts their effect on antibiotic resistance

The structural context of mutations in proteins predicts their effect on antibiotic resistance

Spatial clustering of mutations in Mycobacterium tuberculosis proteins finds proteins that are involved in antibiotic resistance, and predicts which mutations cause resistance.

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Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat avoidance via bidirectional glutamatergic and peptidergic signaling elifesciences.org/articles/1…
Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat...

Starvation transforms signal encoding in C. elegans thermoresponsive neurons and suppresses heat...

Nutritional state dynamically reshapes sensory processing to prioritize behavioral responses, revealing the plastic coupling of sensation, internal state, and behavior.

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CRY me to sleep elifesciences.org/digests/92…

CRY me to sleep

The light receptor CRYPTOCHROME promotes wakefulness during short winter-like days in fruit flies, revealing a seasonal sleep-regulatory mechanism that may provide insights into seasonal affective...

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Early recruitment of membrane-bound DNaseX to phagocytic cups in macrophages elifesciences.org/articles/1…
Early recruitment of membrane-bound DNaseX to phagocytic cups in macrophages

Early recruitment of membrane-bound DNaseX to phagocytic cups in macrophages

Phagocytic cups of macrophages exhibit strong DNase activity during the early stage of phagocytosis, prior to cup closure.

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Genome-wide synthetic lethality screen of Bam complex-associated genes in Escherichia coli elifesciences.org/articles/9…
Genome-wide synthetic lethality screen of Bam complex-associated genes in Escherichia coli

Genome-wide synthetic lethality screen of Bam complex-associated genes in Escherichia coli

High-throughput genetics reveals all synthetic-lethal relationships for outer membrane protein biogenesis associated genes in Escherichia coli.

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Circadian photoreceptor CRYPTOCHROME promotes wakefulness under short winter-like days via a GABAergic circuitry elifesciences.org/articles/9…
Circadian photoreceptor CRYPTOCHROME promotes wakefulness under short winter-like days via a...

Circadian photoreceptor CRYPTOCHROME promotes wakefulness under short winter-like days via a...

The circadian photoreceptor CRYPTOCHROME selectively inhibits sleep under short winter day length by tuning down GABAergic tone within pacemaker neuron network.

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