Elijah Krings

Opening up 3 spots for this months coaching again If you want to work with me 1:1 to resolve long term health issues like: - IBS - IBD - SIBO - Mold - ME/CFS - Fungal Overgrowth - Intestinal Dysbiosis And many more Feel free to apply with the link below: tally.so/r/b5b4N1

When reading a salivary hormone test and seeing low cortisol, I do not look at the adrenals as a root cause Rather the eye-brain-gut-axis This is where most of the adrenal insufficiency stems from: High blue/red light ratio, no consistent circadian pattern and no AM sun gazing to set the circadian clock (eye part) When the gut barrier breaks due to inflammation, the set of neurons responsible for cortisol production is wrecked: The paraventricular nucleus (PVN) is not protected by the BBB, allowing any toxins & cytokines modulating its function You can see this in a progesterone steal syndrome, low cortisol pattern Further pronounced by viruses hijacking the circadian clock through redox modulation

Adrenal fatigue has a huge light component behind it: Blue light directly activates the sympathetic branch, leading to the release of cortisol and catecholamines Red light on the other hand has been shown to modulate parasympathetic function, balancing out some of the effects of blue light This is becoming increasingly important in winters, where the light cycle shortens and we rely on indoor lighting to function Candle, dim, warm lighting that shines from below, rather than above is what your body needs during those times to balance sympathetic with parasympathetic innervation A regular sauna practice or whole body NIR panels also can be a nice addition providing warmth & low energy longer wavelenghts of light

Ketogenic diets are known to be very protective and restorative of the CNS Many mechanisms like HDAC inhibition, redox modulation or changes in GABA:Glutamate balance are discussed, but I also believe one other thing might be important: PPAR-A agonism and plasmalogen synthesis Ketones can activate peroxisomal metabolism through PPAR-Alpha, increasing PL synthesis. This is vastly important as this class of lipids are highly enriched in the vesicles of neurons Without PLs proper communication between synapses is not possible, while there will also be an indirect effect on oxidative stress markers as PLs buffer any insult on neurons This long term keeps the balance between excitation and inhibition. ROS, inflammation and mitochondrial dysfunction all intertwine to increase excitation. Plasmalogens can work on all three of these axis simultaneously to restore homeostassis

A high quality olive oil can be a very nice addition to someones diet "Oh yeah PUFAs" - olive oil is more than that Good olive oil is barely oxidized and it contains plenty of Vit E to do so It is a good source of the omega-9 FA oleic acid which is a PPAR-alpha agonist, boosting peroxisomal metabolism, lowering LDL and increasing HDL It also is a precursor to n9 plasmalogens which are stabilizing cell membranes & protecting them from damage (highly enriched in the heart) The polyphenol hydroxytyrosol has been found to protect membranes, neurons and even mitochondria from oxidative stress, while it also improves membrane potential of the latter, showing it can provide a real increase in energy efficiency & capacity It also can inhibit adhesion of platelets improving hemodynamics (blood flow and therefore oxygen/ nutrient delivery; mechanistically also lowers risk of blood clotting)

An interesting finding in viral infection: Viruses hijack peroxisomal metabolism to protect themselves and leverage our own anabolic pathways for their growth This is pronounced in plasmalogen synthesis, as viruses can either block or use them, both of which minimize host usage/ availability Maybe the wide spread reason PLs precursors have success that they fix a bottleneck created by viral overload. Remember that covid can disrupt gut peroxisomal metabolism, so other viruses could do that as well and on a more systemic scale Issue I am facing: How do we know that the supplementation of PLs could for some cause reactivation of some virus. I have seen no evidence of that but its an after thought

If you want to know the impact that plasmalogens have on our biology, look into edge cases of plasmalogen deficiency Zellweger syndrome (genetic disruption of peroxisomal metabolism) can present on a spectrum, but all of them have a shortened lifespan in common Plasmalogens are so valuable in lipid / membrane physiology as they can buffer ROS, preventing other structural lipids enriched with omega-3s to survive without causing lipid peroxidation cascading Thus PLs keep normal cellular signaling & physiology upright. I think they will play a key role for all of those that suffered for eons without having any true therapeutic lever Combine them with other membrane replacement tools such as PDC, Vit E/Astaxanthin, omega-3 saturation, but also some omega-6 becomedecentralized.substack…

This is your sign to start nasal rinses this fall/winter Especially important in those times of sickness all around you and the constant indoor heating leading to dryer air ways It can be a simple practice of nasal irrigation with some NaCl solution on a daily basis. Takes five minutes a day and compounds over time For those that have constant sinusitis issues it might be worth doing this long term with some antimicrobials, - inflammatories and biofilm busters NAC, Xylitol, Colloidal Silver, Iodine, mild antimicrobial herbs, propolis or even nasal sprays that contain KPV, RS3 or the aforementioned propolis

After improving my near decade long constipation issues through working on the cholinergic system (high dose thiamine, choline) and a well adopted elimination diet Fiber has improved my baseline motility to the next level. Specifically I am talking to soluble, low to medium fermentable ones which do not cause proximal bloating Titrating up on PHGG, Chia, Flax and Psyllium the last weeks really made a difference After that I will trial combinations of those fibers with resistant starches to get the butyrate production on point, while trying more bifidogenic fibers in low controlled dosages like inulin

Human brain evolution is so fascinating Analyzing it deeply will provide you with all the axioms of a proper human diet. It directly counter acts ANY dietary doctrine Carnivores who do not eat fish... Where is the DHA supply? Vegans/Vegetarians... see above multiplied multifold as we will certainly lack Vitamin B12, iron and many more nutrients needed for proper brain development Low fiber diets... We evolved with fiber as they can indeed increase ketone production (as they are turned into SCFAs) which alters epigenetics & provides fuel for the brain. Glucose uptake by the brain is limited, whereas fatty acids can be an unlimited fuel source. Also, SCFAs can be turned to glucose. But the same goes for glucose needed to fuel our high BMR compared to our body mass, while also allowing us to have sufficient energy for the brain to develop. Our brain is an energy hog and compared to our closes ancestors we could've traded a longer gut (fermentation chamber) for higher brain mass This is reflected in the energy our brain consumes in % to all energy burned (20%) which is really high Then by looking into the literature of WHERE we evolved, we likely evolved in a shore based environment where access to all of those food components: fruit, vegetables and fish where available

Mycotherapy (mushrooms as medicine) can be a really powerful tool to have in the immune system arsenal. Apart from peptides & basic micronutrient saturation, these are real levers to be pulled to improve how your immune system works - Cordyceps - Maitake - Chaga - Turkey Tail - Reishi (!) - AHCC (potentially the strongest; a-glucan extract from reishi) Mycotherapist swear on complexes as the sum of all of them is better than any single dosage Typical therapy for chronic issues can be between 6-12 months, for someone who just wants to do a pulsed therapy approach, I think 3-4 months 2x/ year can be really good What makes these interesting that many of these mushrooms can either push towards a certain branch or not, depending on the context E.g. if you need more Th1, you get more Th1. If you need more Tregs, you get them (very dumbed down version of my literature interpretation) A personal protocol for immune boosting could be: - Astragalus membranaceus - Baikal Scullcap - Cordyceps, Reishi, Turkey Tail Then depending on severity pulse through higher dosages and lower dosages throughout one period When you add other pharmacological levers like NAC/B2/Selenium, Black Seed Oil, IP6 you also improve the cytotoxicity of NK/CD8 cells by blocking important pathways that lead to suppression

Been stopping lymph drainage for some weeks now. Bad mistake Had to bring it back as I felt a big difference after a while. My cognition in the morning gets to baseline much faster, I feel less foggy and just lighter My favorite way is to do it right after waking (cue/trigger) and also before any sauna session to improve circulation of toxins & immune cells Doing the Big 6 with some additional head & neck work which also improved my upper back tightness slightly I pay huge attention to the sternocleidomastoid muscle (SCM) as there is a lot of drainage happening from the skull to the body Just saying: these are no replacement for an active life in general Movement & being outside (red light) are natural ways of improving lymphatic drainage

A practical approach to improving insulin resistance: Increase the following micronutrients: Zinc, Vitamin A/D, Chromium, Magnesium, Thiamine, Biotin Some of these can also be supplemented Researched backed to improve insulin sensitivity: Myo-Inositol, L-Carnitin, Alpha Lipoic Acid, Maitake Mushroom (Choose 1-2 of these depending on other issues; e.g. inositol is great for insulin resistance induced hypothyroidism) Circadian Lifestyle: insulin sensitivity and glucose homeostasis follow a natural 24 hour rhythm. Aligning feeding windows & carbohydrate load with that can improve signaling Watching sunrise & sunset, front loading carbohydrates & stop eating once its dark are natural ways to improve insulin resistance Diet & Energy: Depending on the body type (obese, overweight, body fat %) you should go slightly below maintenance (300-500 kcal). Increase protein intake & fat intake, while cycling low carb days with medium carb days (these are on exercise days) Increase carbs around exercise and scale amount with the intensity & type of exercise (e.g. weight lifting or HIIT a bit more vs Zone 2) Exercise: Daily step counting (aiming for at least 10 000), post meal walks to improve post prandial glucose utilization and having a staple exercise regiment I believe a workout plan should have a bit of everything: weight training, zone 2 and HIIT. Depending on body type & circumstance start with zone 2, get into weight lifting on the side and then scale up HIIT work Zone 2 training can be used to improve metabolic flexibility, where I would not eat any carbs beforehand, fuel with some fat & protein and go for a run And then of course: Root causes Obesity, SAD or overfeeding on useless carbs are root causes themselves. But if you are doing most of these already there are some more like mycotoxins/ mold, SIBO/SIFO or even latent viruses inducing autoimmunity in some

21 Mechanisms behind your hypothyroidism: 1. CNS Serotonin deficiency lowering signaling between CNS/thyroid 2. CNS Dopamine deficiency lowering signaling between CNS/thyroid 3. Cytokine induced disruption of CNS-thyroid signaling 4. Elevated prolactin 5. Elevated cortisol 6. Autoimmunity induced TPO destruction 7. Autoimmunity induced thyreoglobulin destruction 8. Progesterone deficiency lowering TPO activity 9. Lack of nutrients (Vit A, D, Zinc, Selenium, Iodine) 10. LPS/Dysbiosis blocking conversion of T4 -> T3 11. Cytokine blocking conversion of T4 -> T3 12. Elevated cortisol blocking conversion of T4 -> T3 13. Peripheral serotonin deficiency blocking conversion of T4 -> T3 14. Peripheral dopamine deficiency blocking conversion of T4 -> T3 15. Peripheral desensitization through testosterone elevation (women) 16. Elevated TGB lowering hormone production (contraceptive induced) 17. Lowered TGB leading to hormone desensitization (estrogen + IR) 18. Hormone desensitization through inflammatio/cytokines 19. Cortisol lowering sensitivity to existing thyroid hormone 20. Lack of Vitamin A lowering thyroid hormone receptor expression 21. Elevated homocysteine lowering thyroid hormone receptor expression

Hypothyroidism cannot be cured "through the thyroid". Its root causes lie deeper: EBV, (any) Herpesvirus, H. Pylori, Intestinal Overgrowths, Long Covid Support while working on the root cause: - Zinc sufficiency - Aloe Vera (inner leaf) - Myo-Inositol + Selenium - Cod Liver Oil (Vitamin A/D) - Iodine through food afterwards - Working on any methylation defects - Plenty of localized red light & UV-A light - Lymphatic Drainage in head & neck region

When I create a protocol for someone, I would always start with the believe that there is no supplement, pill or peptide to be taken Start with diet & lifestyle first: What is the goal of said protocol? What are the underlying root causes? How can I eat to improve said condition? What is missing in terms of improving sleep? Where can I leverage circadian practices in day to day life? How can I regulate the nervous system through mind-body practices? These are questions I am always starting with after I analyzed and assessed the problem. There are hundreds of things to be done without ever touching a supplement. Without being neurotic, see what your floor is and what practices you can repeatedly do to achieve any given goal