Erica Larschan (@EricaLarschan) profile picture

Erica Larschan

@EricaLarschan

I run a research group at Brown University that defines new mechanisms for gene regulation. https://nitter.cf/t.co/CNY3DmHlDI

larschanlab.com
Joined July 2020
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Photo by Erica Larschan (@EricaLarschan)
Gunjan Singh - American Federation for Aging Research afar.org/grantee-profiles/gu…

Gunjan Singh - American Federation for Aging Research

Postdoctoral Fellow, Brown University. Determining the role of Dosage Compensation Complex in regulation of sex-specific aging of brain. Aging and

afar.org
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doi.org/10.7554/eLife.87865 @eLife We are so excited about our new paper defining a new link between splicing and transcription!
Sex-specific splicing occurs genome-wide during early Drosophila embryogenesis

Sex-specific splicing occurs genome-wide during early Drosophila embryogenesis

Combining computational and experimental approaches reveals that the loss of a maternal transcription factor influences sex-biased differential splicing in the early zygotic transcriptome at genes...

elifesciences.org
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$12.5 million grant aims to help researchers better understand aging differences between females and males | The Warren Alpert Medical School of Brown University medical.brown.edu/news/2022-…
$12.5 million grant aims to help researchers better understand aging differences between females...

$12.5 million grant aims to help researchers better understand aging differences between females...

medical.brown.edu
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Check out this exciting new paper we contributed to that provides the first single cell time course of early fly embryogenesis: science.org/doi/10.1126/scie…
The continuum of Drosophila embryonic development at single-cell resolution

The continuum of Drosophila embryonic development at single-cell resolution

A single-cell atlas of chromatin accessibility and gene expression reveals cell lineages and gene expression patterns during Drosophila embryogenesis.

science.org
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Capstones Better Prepare Native Students for College and Careers - Future Focused Education futurefocusededucation.org/2…
Capstones Better Prepare Native Students for College and Careers - Future Focused Education

Capstones Better Prepare Native Students for College and Careers - Future Focused Education

By Miguel S. Maizano | Zuni High School, Senior Honors Project Teacher The capstone project at Zuni High School is not just an alternative for high school graduation, but a pathway for our students...

futurefocusededucation.org
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doi.org/10.7554/eLife.69937 @eLife Check out our new paper on zygotic genome activation!
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Congratulations to all and thanks for a great collaboration! We are very excited about the discovery of a new pioneer TF. doi.org/10.7554/eLife.69937 @eLife
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We are very excited about our new paper! The zinc finger protein CLAMP promotes long-range chromatin interactions that mediate dosage compensation of the Drosophila male X-chromosome | Epigenetics & Chromatin | Full Text epigeneticsandchromatin.biom…

The zinc finger protein CLAMP promotes long-range chromatin interactions that mediate dosage...

Epigenetics & Chromatin - Drosophila dosage compensation is an important model system for defining how active chromatin domains are formed. The male-specific lethal dosage compensation...

link.springer.com
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Erica Larschan retweeted
Perrimon Lab (@PerrimonLab) profile picture
Perrimon Lab@PerrimonLab15 Jun 2021
New paper: TIMEOR: a web-based tool to uncover temporal regulatory mechanisms from multi-omics data. Conard AM, Goodman N, Hu Y, Perrimon N, Singh R, Lawrence C, Larschan E. Nucleic Acids Res. 2021 Jun 14:gkab384. doi: 10.1093/nar/gkab384. PMID: 34125906
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Im pleased to present my novel time-series multi-omics method and web server TIMEOR (Trajectory Inference and Mechanism Exploration with Omics in R) in The NAR Web Server Issue 2021. doi.org/10.1093/nar/gkab384
TIMEOR: a web-based tool to uncover temporal regulatory mechanisms from multi-omics data

TIMEOR: a web-based tool to uncover temporal regulatory mechanisms from multi-omics data

Abstract. Uncovering how transcription factors regulate their targets at DNA, RNA and protein levels over time is critical to define gene regulatory networ

academic.oup.com
Perrimon Lab (@PerrimonLab) profile picturePerrimon Lab@PerrimonLab15 Jun 2021
New paper: TIMEOR: a web-based tool to uncover temporal regulatory mechanisms from multi-omics data. Conard AM, Goodman N, Hu Y, Perrimon N, Singh R, Lawrence C, Larschan E. Nucleic Acids Res. 2021 Jun 14:gkab384. doi: 10.1093/nar/gkab384. PMID: 34125906
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The zinc finger protein CLAMP promotes long-range chromatin interactions that mediate dosage compensation of the Drosophila male X-chromosome biorxiv.org/content/10.1101/…
The zinc finger protein CLAMP promotes long-range chromatin interactions that mediate dosage...

The zinc finger protein CLAMP promotes long-range chromatin interactions that mediate dosage...

Drosophila dosage compensation is an important model system for defining how active chromatin domains are formed. The Male-specific lethal dosage compensation complex (MSLc) increases transcript...

biorxiv.org
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TIMEOR: a web-based tool to uncover temporal regulatory mechanisms from multi-omics data biorxiv.org/content/10.1101/… Congrats Ashley on this amazing tool that will be so useful for so many labs!
TIMEOR: a web-based tool to uncover temporal regulatory mechanisms from multi-omics data

TIMEOR: a web-based tool to uncover temporal regulatory mechanisms from multi-omics data

Uncovering how transcription factors (TFs) regulate their targets at the DNA, RNA and protein levels over time is critical to define gene regulatory networks (GRNs) in normal and diseased states....

biorxiv.org
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Amazing graphics!
Image from Erica Larschan (@EricaLarschan)
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CLAMP and Zelda function together as pioneer transcription factors to promote Drosophila zygotic genome activation biorxiv.org/content/10.1101/…
CLAMP and Zelda function together as pioneer transcription factors to promote Drosophila zygotic...

CLAMP and Zelda function together as pioneer transcription factors to promote Drosophila zygotic...

Because zygotic genome activation (ZGA) is an essential process across metazoans, it is key to evolve multiple pioneer transcription factors (TFs) to protect organisms from loss of a single factor....

biorxiv.org
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