@FaceBaseDataHub

NIDCR-funded repository and resource empowering dental, oral & craniofacial research (including related biological and anatomical health/disease domains).

facebase.org
Joined August 2020
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Nerves don't just wire up muscle - they help build it. New in FaceBase: single-cell, bulk RNA-seq, and SeqFISH showing trigeminal nerve-derived GDF11 shaping soft palate muscle architecture. @CCMB_USC #craniofacial #scRNAseq #spatialtranscriptomics facebase.org/2026/08/25/rece…

New release: Sensory nerve-derived signaling coordinates oropharyngeal structural organization that...

A new dataset from the Chai lab at the University of Southern California is now available in FaceBase, combining single-cell RNA sequencing, bulk RNA sequencing, and SeqFISH spatial transcriptomics...

facebase.org
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It's that time again! Join us for Office Hours this week: 📅 Wed, August 26, 1 pm Eastern / 10 am Pacific Ask the FaceBase team about finding, submitting, and citing data and more! Register: usc.zoom.us/meeting/register… #craniofacial @NIDCR_NIH #innerear @NIH_NIDCD #OpenData
Promotional graphic for FaceBase Office Hours, held the last Wednesday of the month at 10 am PT / 1 pm ET. Dark blue background with a "Register now" button and a phone displaying the FaceBase logo and www.facebase.org.

ALT Promotional graphic for FaceBase Office Hours, held the last Wednesday of the month at 10 am PT / 1 pm ET. Dark blue background with a "Register now" button and a phone displaying the FaceBase logo and www.facebase.org.

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New in FaceBase: two needs assessment datasets from the Center for TMD IMPACT at USC — one surveying 103 patients with TMD, one surveying 17 clinicians who treat them. Same clinical encounter, two vantage points. De-identified and open access. facebase.org/2026/08/18/rece…

New release: Center for TMD IMPACT (C-TMD IMPACT) Patient and Clinician Needs Assessment

Two new datasets from the Center for TMD IMPACT (C-TMD IMPACT) are now available in FaceBase. Together, they offer a view of common needs and common barriers from both sides of the clinical encount...

facebase.org
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Why do some cranial sutures fuse too early? New FaceBase data point to timing: FGFR2 signaling normally declines after birth, dialing down retinoic acid to keep the coronal suture open. Overactivate it and the suture closes. Chai lab, USC. @CCMB_USC facebase.org/2026/08/04/rece…
FGFR2-RA signaling governs dura mater-suture mesenchyme interaction during early postnatal development to control coronal suture development and craniosynostosis. Illustration created with BioRender.com.

ALT FGFR2-RA signaling governs dura mater-suture mesenchyme interaction during early postnatal development to control coronal suture development and craniosynostosis. Illustration created with BioRender.com.

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How do continuously growing teeth withstand constant mechanical load? New FaceBase data identify a KDM6B–BMI1–PIEZO1 "mechanostat" that shields incisor progenitors from stress-induced apoptosis. Bulk RNA-seq + Cut&Run-seq, Chai lab, USC. @CCMB_USC facebase.org/2026/07/30/rele…
Schematic representation of KDM6B safeguarding tissue homeostasis to mechanical stress through epigenetic control of PIEZO1- mediated mechanotransduction. Using the mouse incisor as a model of mechanical loading, we reveal that within TACs, Kdm6b demethylates H3K27me3, thereby relieving the repression of the Bmi1 gene. Normal BMI1 inhibits Piezo1 expression. This maintains physiological PIEZO1 levels, ensuring calibrated Ca2+ influx for proliferation and differentiation. In contrast, loss of Kdm6b leads to an accumulation of H3K27me3 at the Bmi1 promoter region, which silences Bmi1 expression and diminishes BMI1 formation. This reduction results in pathologically increased PIEZO1 ion channels in the membrane. The subsequent Ca2+ overload triggers TAC apoptosis while reducing proliferation and differentiation. Ultimately, these molecular events compromise tissue homeostasis. Schematic created with BioRender.com. Ho, T. (2026) https://BioRender.com/8mzv4a

ALT Schematic representation of KDM6B safeguarding tissue homeostasis to mechanical stress through epigenetic control of PIEZO1- mediated mechanotransduction. Using the mouse incisor as a model of mechanical loading, we reveal that within TACs, Kdm6b demethylates H3K27me3, thereby relieving the repression of the Bmi1 gene. Normal BMI1 inhibits Piezo1 expression. This maintains physiological PIEZO1 levels, ensuring calibrated Ca2+ influx for proliferation and differentiation. In contrast, loss of Kdm6b leads to an accumulation of H3K27me3 at the Bmi1 promoter region, which silences Bmi1 expression and diminishes BMI1 formation. This reduction results in pathologically increased PIEZO1 ion channels in the membrane. The subsequent Ca2+ overload triggers TAC apoptosis while reducing proliferation and differentiation. Ultimately, these molecular events compromise tissue homeostasis. Schematic created with BioRender.com. Ho, T. (2026) https://BioRender.com/8mzv4a

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It's that time again! Join us for our Office Hours tomorrow: 📅 Wednesday, July 29, 1 pm ET / 10 am PT Zoom with FaceBase team members and ask questions about finding data, submitting data, citing data, and more things data! Click here to register: usc.zoom.us/meeting/register…
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Save the date! The 2027 FaceBase Community Forum heads to Los Angeles — April 27–28, 2027, at USC/ISI in Marina del Rey. Details soon: bit.ly/FBForum2027
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New #FaceBase dataset: scRNA-seq of the enamel organ in an AmelxS16A knock-in mouse reveals 624 differentially expressed genes & major dysregulation of Shh and Wnt5a in secretory ameloblasts. Open data from Beniash/Margolis, Univ of Pittsburgh @PittTweet: doi.org/10.25550/AF-V3VC
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We have extended the poster abstract deadline for the 2026 FaceBase Annual Meeting. Share your work and connect with the craniofacial research community! Deadline is now: Friday, April 24. Submit here → facebase.org/community/annua…
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New on FaceBase 🧬 Xu, Liu & Jiang (Cincinnati Children's) contribute Six2 and CTCF ChIP-seq datasets from wildtype mouse embryonic facial tissues (E10.5–E13.5), shedding light on the regulatory landscape of craniofacial morphogenesis. doi.org/10.25550/7Z-41CW
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📋 A few days left to submit a poster abstract for the 2026 FaceBase Annual Meeting! Share your work and connect with the craniofacial research community. Deadline: Friday, April 17. Submit here → facebase.org/community/annua…
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New on FaceBase 🧬 Data from Ma & Rosin examines how prenatal depletion of CSF1R+ macrophages and osteoclasts disrupts craniofacial development with effects on the skull, mandible, palate, ear ossicles, and more. Dataset + publication now available. facebase.org/2026/04/09/rece…
An example one of the PLX5622 treated P1 skulls. Image by Felix Ma and Jessica M. Rosin.

ALT An example one of the PLX5622 treated P1 skulls. Image by Felix Ma and Jessica M. Rosin.

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Will you be at AADOCR/IADR or GRC? FaceBase will be in Ventura and San Diego with demos, presentations, and opportunities to connect with our team. See where to find us! facebase.org/2026/03/19/face…
A view of the San Diego Convention Center, where the AADOCR/IADR will be held next week. See FaceBase in Booth 402!

ALT A view of the San Diego Convention Center, where the AADOCR/IADR will be held next week. See FaceBase in Booth 402!

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FACEBASE COMMUNITY FORUM 🗓 Abstract Deadline for Talk Consideration - This Friday, March 20! Submissions will remain open after this first deadline. This deadline only applies to abstracts that would like to be considered for a talk. Submit abstract: facebase.org/community/annua…

Call for Abstracts for the 2026 FaceBase Community Forum

FaceBase is the primary data resource for dental, oral and craniofacial researchers worldwide.

facebase.org
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New data: Spatial transcriptomics (using seqFISH) reveals a fibroblast-immune microenvironment remodeling pathway in CFA-induced TMJ arthritis in mice. PI: Jian-Fu Chen (University of Southern California) @CCMB_USC
Spatial transcriptomics of the mouse temporomandibular joint (TMJ) using seqFISH, from the dataset "Spatial Transcriptomics of Mouse CFA-induced TMJ arthritis" https://doi.org/10.25550/8Q-3KAR)

ALT Spatial transcriptomics of the mouse temporomandibular joint (TMJ) using seqFISH, from the dataset "Spatial Transcriptomics of Mouse CFA-induced TMJ arthritis" https://doi.org/10.25550/8Q-3KAR)

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It's that time again! Join us for our Office Hours this week: 📅 Wednesday, Feb 25, 1 pm ET / 10 am PT Zoom with FaceBase team members and ask questions about finding data, submitting data, citing data, and more things data! Click here to register: usc.zoom.us/meeting/register…
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New: microCT data from ameloblast-specific Smad4 knockout and Ambn-IRESCre mice. Using a novel ameloblast-restricted Cre line, these data reveal severe enamel-specific pathology and highlight Ambn-IRESCre as a powerful tool for enamel gene function study: facebase.org/2026/02/11/rece…
Mutant sample from the dataset MicroCT analysis of ameloblast specific Smad4 conditional knockout mice

ALT Mutant sample from the dataset MicroCT analysis of ameloblast specific Smad4 conditional knockout mice

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Registration and Call for Abstracts are open for the FaceBase 2026 Community Forum! Advances in data reuse, integration, and AI-ready research in DOC, inner ear and related research. 📅 May 4-5, 2026 📍 Arlington, VA (also via Zoom) Register: bit.ly/FBForum2026
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New data release: Justin Cotney’s lab (CHOP) generated a single-nucleus RNA sequencing (snRNA-seq) atlas of critical time points during human and mouse craniofacial development, now openly available through FaceBase. Read all about it here: facebase.org/2026/01/20/rece…
Figure from Manchel et al 2026

ALT Figure from Manchel et al 2026

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Save the dates for the next FaceBase Community Forum: May 4 & 5 2026 in Arlington, VA. More details coming soon! facebase.org/community/annua…
Save the Dates for the 2026 FaceBase Community Forum in Arlington, VA on: May 4 & 5 2026! For updates, go to:https://bit.ly/FBForum2026

ALT Save the Dates for the 2026 FaceBase Community Forum in Arlington, VA on: May 4 & 5 2026! For updates, go to:https://bit.ly/FBForum2026

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