@FraLo05
 Trento, Trentino-Alto Adige
Joined July 2017
  • Tweets62
  • Following82
  • Followers75
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Francesca Lorenzin retweeted
Gian Marco Franceschini@GMFranceschini
Sep 2
nature.com/articles/s41568-0…

Origins and consequences of oncogenic 3D chromatin remodelling

Nature Reviews Cancer - In this Review, Franceschini and colleagues discuss how remodelling of the 3D structure of chromatin in cancer is both a cause and a consequence of genetic and epigenetic...

nature.com
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Favorite study! Germline-somatic tandems dictate cancer subtypes, provide clinical insights, and fuel molecularly informed studies. Kudos: Blerta Stringa, @Paola_Gasperini, Alessandro Alaimo, and @LunardiLabCIBIO (co-last a!) @NimaSharifiMD doi.org/10.1158/2159-8290.CD… @UniTrento
Germline-somatic tandems increase cell fitness, favoring cell transformation. This type of germline-somatic tandem is detectable through association studies testing hypothesis-constrained germline variants and molecular subclasses of human tumors.

ALT Germline-somatic tandems increase cell fitness, favoring cell transformation. This type of germline-somatic tandem is detectable through association studies testing hypothesis-constrained germline variants and molecular subclasses of human tumors.

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Francesca Lorenzin retweeted
Thomas Cantore@cantore_thomas
1 Mar 2025
❗️Excited to share my PhD work in Genome Biology: PRODE recovers essential and context-essential genes through neighborhood-informed scores. What is PRODE, and how does it help?👇
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How can we make PARP inhibitors more effective in castration-resistant prostate cancer? @FrancescaBZNY et al. identify the DNA repair gene LIG1 as a sensitizer to PARP inhibitors in multiple tumor models: jci.org/articles/view/179393 @FraLo05 @GiuliaFracassi_ @CIBIO_UniTrento @AIRC_it @PCF_Science @ERC_Research
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Our latest paper describing a role for SCAF1 in promoting RNAPII elongation is online at Nucleic Acids Research @NAR_Open! Check it out here: doi.org/10.1093/nar/gkae1219. Big thanks to collaborators @erhard_lab, @MYCGyvers and AG Schlosser!

Phenotypic screens identify SCAF1 as critical activator of RNAPII elongation and global transcrip...

Abstract. Transcripts produced by RNA polymerase II (RNAPII) are fundamental for cellular responses to environmental changes. It is therefore no surprise t

academic.oup.com
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Proud of our LIG1 loss/PARP inhibition #SL study in @jclinicalinvest by @GiuliaFracassi_ an @AIRC_it fellowship awardee and @FraLo05 a @PCF_Science YIA Collaborators: @quimmateo @FdAdF66 Relevant to #prostatecancer and beyond. Download it! jci.org/articles/view/179393
Giulia Fracassi@GiuliaFracassi_
27 Dec 2024
🚨 New Preprint Alert! 🚨 I’m thrilled to share our latest study now online on JCI: 
CRISPR/Cas9 screens identify LIG1 as a sensitizer of PARP inhibitors in castration-resistant prostate cancer. 🔬 Check out the preprint here: doi.org/10.1172/JCI179393 Huge thanks to @FrancescaBZNY, @FraLo05, all Demichelis’ lab members and facilities staff at @UniTrento @CIBIO_UniTrento, and key collaborators @quimmateo, @FdAdF66 and Helmut Klocker. Special thanks to Fondazione Trentina per la Ricerca sui Tumori, @AIRC_it fellowship, @ERC_Research, @PCF_Science, and MIUR. #ProstateCancer #CRPC #LIG1 #PARPi #Biomarker #SyntheticLethality #PrecisionMedicine
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Francesca Lorenzin retweeted
Giulia Fracassi@GiuliaFracassi_
27 Dec 2024
🚨 New Preprint Alert! 🚨 I’m thrilled to share our latest study now online on JCI: 
CRISPR/Cas9 screens identify LIG1 as a sensitizer of PARP inhibitors in castration-resistant prostate cancer. 🔬 Check out the preprint here: doi.org/10.1172/JCI179393 Huge thanks to @FrancescaBZNY, @FraLo05, all Demichelis’ lab members and facilities staff at @UniTrento @CIBIO_UniTrento, and key collaborators @quimmateo, @FdAdF66 and Helmut Klocker. Special thanks to Fondazione Trentina per la Ricerca sui Tumori, @AIRC_it fellowship, @ERC_Research, @PCF_Science, and MIUR. #ProstateCancer #CRPC #LIG1 #PARPi #Biomarker #SyntheticLethality #PrecisionMedicine
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🔥Post-doc position open🔥 at the Demichelis laboratory @UniTrento ⏳ application by August 31st! 👉 more info evitasociety.org/index.php/a… #oncosome #prostatecancer #evitians @CaterinaNardel1 @FrancescaBZNY
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Francesca Lorenzin retweeted
Yari Ciani@YariCiani
9 Jul 2024
I had the honor of writing a preview of the article published by @ICasanovaSalas et al. in the latest issue of @Cancer_Cell . doi.org/10.1016/j.ccell.2024…
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Francesca Lorenzin retweeted
Fondazione Pezcoller@pezcoller
25 Jun 2024
The recipient of @embojournal Molecular Medicine poster prize is: Fracassi Giulia @GiuliaFracassi_ @CIBIO_UniTrento @UniTrento
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Francesca Lorenzin retweeted
Cusanelli Lab@LabCusanelli
13 Jun 2024
Happy to share our recent publication on #TERRA participating in #telomerase regulation at human #telomeres. science.org/doi/10.1126/scia…. Great work from @Bettinnicole_ and coworkers in collaboration with Chartrand lab @UMontreal. @ScienceAdvances @AIRC_it @CIBIO_UniTrento @UniTrento

TERRA transcripts localize at long telomeres to regulate telomerase access to chromosome ends

TERRA transcripts inhibit telomere elongation by impairing telomerase access to chromosome ends.

science.org
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We are recruiting: ERC- and DFG-funded PhD positions in Tumor Biology (Kiel, Germany). We look forward to your application!
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Francesca Lorenzin retweeted
Enrico Domenici@EnriDomenici
7 Jun 2024
Interested in the interplay between human #genetics and the #microbiome ? Nice opportunity for a #PhD position in my lab at @CIBIO_UniTrento in collaboration with @asnicar and @nsegata at @cibiocm Check for scholarship 1C here: unitn.it/en/ateneo/1961/anno… deadline 17th June
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CIBIO is hosting Titia De Lange from @RockefellerUniv winner of the 2024 @pezcoller @aacr Award for the Pezcoller Lecture: Telomeres and #Cancer: Tumor Suppression and Genome Instability 🗓️ May 10th, 2.30 p.m. 🏦 Sala Stringa, FBK ℹ️ webmagazine.unitn.it/node/12… #CIBIO
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The department has launched a call to fill a tenure-track assistant professor position in molecular biology (RTT, BIO/11). Send your applications in! 📅 May 16th, 12.00 ➡️ Apply here: lavoraconnoi.unitn.it/bando-… #ScienceJobs #research
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Francesca Lorenzin retweeted
Abdallah Gaballa@AbdallahHatem4
17 Feb 2024
Have you ever wondered if transcription elongation could influence tumor immune evasion? Happy to share results from my PhD work @MYCGyvers @Uni_WUE published @NatureComms. Check it out nature.com/articles/s41467-0… #MYC #PAF1c #PDAC #immune_evasion #PDAC 1/2
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Francesca Lorenzin retweeted
Luca Fava@LucaFava14
14 Feb 2024
A couple of years ago Andi @villunger and I suspected that extra centrosomes kill blood cells via Caspase-2. Problem was: ko of candidate substrates had no phenotype. Now @dario_rizz and @VincenzaVigo figured out why dlvr.it/T2lg8S
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Francesca Lorenzin retweeted
The EMBO Journal@embojournal
7 Feb 2024
Surprising mechanism revealed by androgen-independent PSA spikes in chronic prostate inflammation: EV-delivered TRPM8 mRNA promotes TLR3 & NF-kB signaling, and antitumorigenic sterile inflammation @AlessandroAlai7 @LunardiLabCIBIO et al @CIBIO_UniTrento embopress.org/doi/full/10.10…
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Francesca Lorenzin retweeted
PCF Science@PCF_Science
24 Jan 2024
ANNOUNCEMENT: RFA for 2024 @PCFnews Young Investigator Award Applications, to support innovative & highly promising early career #ProstateCancer researchers. DEADLINE: 4/15/24 Application Portal opens 1/29/24 pcf.smartsimple.com View the RFA here: res.cloudinary.com/pcf/image…
Prostate Cancer Foundation 2024 Young Investigator Awards REQUEST FOR APPLICATIONS Award Description The Prostate Cancer Foundation (www.pcf.org) champions investment in human capital to fast-forward solutions for prostate cancer with the ultimate goal of ending death and suffering from metastatic prostate cancer. We continue to focus significant efforts on developing gifted cohorts of young prostate cancer researchers. Since 2007, PCF has awarded 407 PCF Young Investigator Awards in 13 countries, making it one of the most prodigious, productive, competitive and prestigious early career awards in cancer research. We are pleased to announce a new round of funding for PCF Young Investigators. We especially encourage young investigators working on prostate cancer health disparities to apply. The mission of PCF is to fund research addressing unmet medical needs in the diagnosis and treatment of potentially lethal prostate cancer. PCF Young Investigator Awards will be 3 years in...

ALT Prostate Cancer Foundation 2024 Young Investigator Awards REQUEST FOR APPLICATIONS Award Description The Prostate Cancer Foundation (www.pcf.org) champions investment in human capital to fast-forward solutions for prostate cancer with the ultimate goal of ending death and suffering from metastatic prostate cancer. We continue to focus significant efforts on developing gifted cohorts of young prostate cancer researchers. Since 2007, PCF has awarded 407 PCF Young Investigator Awards in 13 countries, making it one of the most prodigious, productive, competitive and prestigious early career awards in cancer research. We are pleased to announce a new round of funding for PCF Young Investigators. We especially encourage young investigators working on prostate cancer health disparities to apply. The mission of PCF is to fund research addressing unmet medical needs in the diagnosis and treatment of potentially lethal prostate cancer. PCF Young Investigator Awards will be 3 years in...

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I am beyond excited to see our work out in @CD_AACR . We established a targeted sequencing assay to non-invasively monitor treatment resistance in advanced prostate cancer. Want to know more? Let’s take a short walk 👣 aacrjournals.org/cancerdisco…
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