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Investments at the Intersection of Neuroscience, Psychedelics & Technology

Joined January 2021
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Xenon Pharmaceuticals Reports Promising Results for Two Non-Opioid Pain Drugs: jlsfund.substack.com/p/xenon… @XenonPharma #opioids
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Rhelion Life Sciences Expands Psilocybin Research With New Swedish University Agreement: jlsfund.substack.com/p/rheli… #psilocybin @rhelionLS
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Dr. Albert Garcia-Romeu spoke with MedPageToday about preliminary research from UCSF on psychedelics for depression and anxiety in people with Parkinson’s disease. He also discussed the potential to ease the psychological burden of neurodegenerative diseases, with a related trial in Garcia-Romeu’s lab at Johns Hopkins CPCR for those with mild cognitive impairment or early-stage Alzheimer’s disease, where findings are expected next year. medpagetoday.com/neurology/p…
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New Study Finds Psychedelic Nasal Spray Could Offer Rapid Relief From Severe Depression: jlsfund.substack.com/p/new-s… @ataibeckley #depression #psychedelics
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FDA Clears Nationwide Recruitment for Brain Implant That Helps Paralyzed Patients Speak Again: jlsfund.substack.com/p/fda-c… @paradromics
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A fascinating UCSF study on psilocybin for Parkinson's. The potential for psychedelics to reduce mitochondrial stress and inflammation is one of the most exciting areas of emerging research in our field. If you want to dig deeper into the science, check out the work of Dr. Chuck Nichols at LSU. IMHO, we should be adding these biomarkers to human psychedelic studies, as the implications are just massive. If you're a researcher in the field. I'd love to hear your thoughts on the most relevant, cost-effective measures we could be adding to new studies. cc. @MitoPsychoBio @EllenBradleyMD
Another win for psilocybin In 9 Parkinson's patients... GDF15 fell > 17.4% after 10 mg > 13.9% after 25 mg High GDF15 signals mitochondrial failure and neurodegeneration. Inflammation also declined: > IL-6: −17% > IL-8: −20% > hsCRP: −9.6% > IL-10: +2.7% (anti-inflammatory)
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Paradromics Partners With Siemens to Improve Brain Implant Surgery: jlsfund.substack.com/p/parad… @paradromics #bci #braincomputerinterface
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R.I.S.E. Summit November 12th Irvine California Exploring psychedelic treatments for addiction recovery I have one free registration to give away to the most deserving : ) make your case. etheridgefoundation.org/rise…
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New Non-Opioid Pain Drug Delivers Promising Phase 3 Results: jlsfund.substack.com/p/new-n… #opioids
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Arrowhead Pharmaceuticals' Experimental Alzheimer's Drug Delivers Promising Early Results: jlsfund.substack.com/p/arrow… @ArrowheadPharma #alzheimers
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Eton Pharmaceuticals and Aquestive Therapeutics Team Up to Bring New Epilepsy Treatment to Patients: jlsfund.substack.com/p/eton-… #epilepsy
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IGC Pharma Unveils New AI Platform to Help Identify Alzheimer's Risk Earlier: jlsfund.substack.com/p/igc-p… @IgcPharmaSAS #alzheimers
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Ontario Research Hospital Receives $2M in Gifts for Psychedelics Centre St Joseph’s Healthcare Hamilton has received $1M apiece from two philanthropic sources to support its Centre for Health Innovation and Research in Psychedelics, or CHIRP. The centre is currently running three trials: psilocybin for chronic pain and two studies looking at psilocybin for cannabis use disorder. Read more on our website: psychedelicalpha.com/news/p%…
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UCSF to Test Psilocybin as a Treatment for Methamphetamine Addiction: jlsfund.substack.com/p/ucsf-… #addiction
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Viatris Bets $1.65 Billion on Alternatives to Opioid Painkillers: jlsfund.substack.com/p/viatr… @ViatrisInc @PaciraBio #opioids
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PharmAla and Rua Bioscience Bring Medicinal MDMA to New Zealand: jlsfund.substack.com/p/pharm… @PharmAlaBiotech #MDMA #PTSD
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NIMH Grant Opportunity The National Institute of Mental Health (NIMH) is set to share a grant opportunity to support the implementation of ‘rapid-acting psychotropic interventional drugs’, or RAPIDs, which includes ketamine and psychedelics.  The program is geared around real-world effectiveness and expects to award $20M across three projects.  It will be posted tomorrow, October 10th. Read more on our website: psychedelicalpha.com/news/p%…
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This Technology Could Help Scientists Identify Failed Brain Drugs Before Human Trials: jlsfund.substack.com/p/this-…
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