Professor for Epigenetics @ LMU Munich, interested in chromatin, endogenous retroviruses and transcription factor biology
Munich
Joined September 2019
- Tweets15
- Following36
- Followers126
- Likes14
Setdb1 silences ERV derived cryptic enhancers to ensure proper hematopoiesis. Although transcription factors, such as PU.1, can bind to H3K9me3 heterochromatin, their activity is inhibited by Setdb1.
out in PNAS: doi.org/10.1073/pnas.2409656…
H3K9me3 is not sufficient for silencing endogenous retroviruses if DNA methylation is perturbed. In Dnmt1 ko endoderm cells, IAP elements fully maintain H3K9me3, while trancriptionally active.
great collaboration with @LickertHeiko
out in @NatureComms
rdcu.be/cVRqS
Gunnar Schotta retweeted
DNA sequence-dependent formation of heterochromatin nanodomains [Graeme Thorn, Christopher Clarkson, Anne Rademacher, Hulkar Mamayusupova, Gunnar Schotta, Karsten Rippe & Vladimir Teif] nature.com/articles/s41467-0…
ChromHL software here: github.com/TeifLab/ChromHL
Cartoon as a bonus!
Gunnar Schotta retweeted
Here is our Snapshot of Human Endogenous Retroviruses (HERVs) that I wrote together with @JakobssonLab for Cell (@CellCellPress). Enjoy reading here: authors.elsevier.com/a/1eS8a… - @HelmholtzMunich @Lund_Stem
G-quadruplexes are cell type-specific and associated with high transcription. Great collaboration with @RichterLabUnipd @SaraNRichter_
Check out our latest research on how G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome.
nature.com/articles/s41467-0…
@GSchotta @FCernilogar @RichterLabUnipd
Morc3 silences endogenous retroviruses by enabling Daxx-mediated H3.3 incorporation. Morc3 GHKL ATPase domain dimerizes for Daxx interaction. An efficient ATPase cycle is critical for H3.3 incorporation. biorxiv.org/cgi/content/shor…
HIV infection activates ERVs to regulate antiviral gene expression. Great collaboration headed by Daniel Sauter! academic.oup.com/nar/advance…
G4 quadruplex structures are cell type specific and associate with highly expressed genes. New preprint of a collaborative project led by @SaraNRichter_ biorxiv.org/cgi/content/shor…
Gunnar Schotta retweeted
Ever wonder why children react differently to pathogens? Join our lab and help us find out! uni-muenchen.de/aktuelles/st…
Gunnar Schotta retweeted
The Kidney Contains Ontogenetically Distinct Dendritic Cell and Macrophage Subtypes throughout Development That Differ in Their Inflammatory Properties @buschraml @gschotta @FCernilogar
bit.ly/30jo4CY
