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Schwann cells have a limited window of time in which to initiate myelination program during early...

The temporal control of mitotic exit of individual Schwann cells (SCs) is essential for radial sorting and peripheral myelination. However, it remains unknown when, during their multiple rounds of...

Understanding Antisense Oligonucleotide Efficiency in Inhibiting Prokaryotic Gene Expression

Abstract. Oligonucleotides offer a unique opportunity for sequence specific regulation of gene expression in bacteria. A fundamental question to address is

Investigation of the pathogenesis of ADAR1 gene in dyschromatosis symmetrica hereditaria

The pathogenesis of dyschromatosis symmetrica hereditaria (DSH) has not been well defined. In this study, we sought to investigate the influence of the ADAR1 gene on DSH both in vitro and in vivo....

Long-range chemical signalling in vivo is regulated by mechanical signals

Biological processes are regulated by chemical signals (e.g., morphogens, growth factors, and guidance cues) and mechanical signals (e.g., tissue stiffness and cellular forces). Yet, the interaction...

FARS2 Deficiency Causes Cardiomyopathy by Disrupting Mitochondrial Homeostasis and the Mitochondr...

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common heritable heart disease. Although HCM has been reported to be associated with many variants of genes involved in sarcomeric protein biomech...

Localization and function of key axonemal microtubule inner proteins and dynein docking complex...

Vertebrate motile cilia are broadly classified as (9+2) or (9+0), based on the presence or absence of the central pair apparatus, respectively. Cryogenic electron microscopy (cryo-EM) analyses of...

Positive Phase 2 Data for SRP-5051 in Duchenne Muscular Dystrophy | AJMC

The Momentum trial from Sarepta Therapeutics is investigating SRP-5051 (vesleteplirsen) for use among male patients aged 8 to 21 years who have Duchenne muscular dystrophy amenable to exon 51...

Cell contacts and pericellular matrix in the Xenopus gastrula chordamesoderm

Convergent extension of the chordamesoderm is the best-examined gastrulation movement in Xenopus. Here we study general features of cell-cell contacts in this tissue by combining depletion of...

An alternative strategy to increasing influenza virus replication for vaccine production in chicken...

Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance

The hypoxic pattern of glioblastoma (GBM) is known to be a primary cause of radioresistance. Our study explored the possibility of using gene knockdown of key factors involved in the molecular...