Asymmetric Synthesis and Chemical Biology
San Diego, CA
Joined June 2017
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You forgot to mention the PhD's beat the PhD Candidates in volleyball
a successful beach day (most) of the organic chemistry groups along with a PhDs vs Candidates volleyball match! (a few injuries, no deaths) @GustafsonLab @jillalty @barneygrubbs @QJBruch Prof. Katherine Aubrecht and Prof. Matthew Parkers Group
Another day another preprint on ChemRxiv!
“Leveraging Atropisomerism to Obtain a Mutant-Selective c-KIT Inhibitor in Gastrointestinal Stromal Tumors”
A story of privileged heterocycles, atropisomerism and kinase selectivity.
chemrxiv.org/doi/full/10.264…
The R-atropisomer* maintained potency against cellular models of GIST (IC50 < 10 nM) while displaying improved target selectivity, including towards key oncogenic c-KIT mutants. *Cahn-Ingold-Prelog priorities cause the analogs to have opposite stereochemical descriptors.*
Excited to share our new ChemRxiv preprint:
“Leveraging Conformational Control of Neratinib’s C–N Axes to Enhance HER4 Selectivity in Ovarian Cancer”
congrats to the tam @StonyBrookChem and @SDSUChemBiochem
Read here: doi.org/10.26434/chemrxiv.15…
The ‘conformational mapping’ of diarylamine crystal structures suggested that the pan-HER kinase inhibitor neratinib adopts two planar conformations around a C–N axes (similar to cis and trans alkenes). HER family kinases generally preferred the ‘trans’ conformation
The final version of this manuscript is up at @ACSCatalysis
pubs.acs.org/doi/10.1021/acs…
I am sharing this preprint from my group. Inspired by all the great recent skeletal editing work, we developed an atropisomer selective strategy to take Indoles to quinolines. chemrxiv.org/engage/chemr...
Gustafson Group @ Stony Brook retweeted
Our department (@StonyBrookChem) is looking for a PRODiG+ fellow – the appointment is two years, followed by conversion to a tenure-track assistant professor at the conclusion of the fellowship. A unique opportunity!
apply.interfolio.com/178732
Reposting. One more week until the deadline!
The Stony Brook Chemistry Department is searching for a Chemical Biologist at the Associate or Full professor Level. Come join us on Long Island and do some great science! apply.interfolio.com/174211
Gustafson Group @ Stony Brook retweeted
Doctor Gavin Rustin we salute you
Check out our latests work in collaboration with @Taylorlab_Chem ! We evaluated their biomolecular photocaged trifluormethylation reagent on small molecules, finding it effected the rapid trifluoromethylation of diverse aromatics, including several APIs.
chemrxiv.org/engage/chemrxiv…
Check out our latests work in collaboration with @Taylorlab_Chem ! We evaluated their biomolecular photocaged trifluormethylation reagent on small molecules, finding it effected the rapid trifluoromethylation of diverse aromatics, including several APIs.
chemrxiv.org/engage/chemrxiv…
The Stony Brook Chemistry Department is searching for a Chemical Biologist at the Associate or Full professor Level. Come join us on Long Island and do some great science! apply.interfolio.com/174211
Gustafson Group @ Stony Brook retweeted
Professor Jeff Gustafson (Stony Brook University, @GustafsonLab) (gustafsongroup.sdsu.edu/word…) presented the Organic Syntheses Lecture at Notre Dame on September 24th, 2025.
Gustafson Group @ Stony Brook retweeted
Come join us at @StonyBrookChem! We are looking for an Assoc/Full Prof in Materials or Polymer Chemistry, supported by the SUNY Empire Innovation Program. Deadline Oct 16. Reach out if you have any questions! apply.interfolio.com/173681 #facultychemjobs
Just got back from another excellent Heterocyclic Compounds GRC and am excited to have been elected Vice-Chair. I look forward to putting together an exciting program in 2027! Happy to hear any cool ideas for session topics.
Gustafson Group @ Stony Brook retweeted
Call for Abstracts: An oral symposium on Synthetically Modified Nucleosides and Nucleic Acids on October 26, 2025 at the @CaliforniaACS Western Regional Meeting in San Jose! Apply, share widely, and DM or email me with questions. wrm2025.org/index.php/progra…
Gustafson Group @ Stony Brook retweeted
This week marked the Third SBU-BNL Photochemistry Supergroup, with a great poster session and 10 speakers from @StonyBrookChem and MSCE, @BrookhavenLab, @QC_News, @HofstraU, and @AdelphiU! Thanks to @SBUResearch for supporting this event!
I am sharing this preprint from my group. Inspired by all the great recent skeletal editing work, we developed an atropisomer selective strategy to take Indoles to quinolines. chemrxiv.org/engage/chemr...
here is the correct link: chemrxiv.org/engage/chemrxiv…