@HTanerTeker

Asst. Prof.

Joined March 2020
  • Tweets3.5K
  • Following1.3K
  • Followers108
Wow! multiple sclerosis is caused by viral reactivation in monocytes and B cells months before clinical onset. nature.com/articles/s41591-0…

EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse

Nature Medicine - Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to...

nature.com
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Review: Genetically engineered dendritic cells in cancer immunotherapy nature.com/articles/s41698-0…
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Blocking PD-L2 prevents senescent cell accumulation and age-related dysfunction cell.com/cell-metabolism/abs…

Blocking PD-L2 prevents senescent cell accumulation and age-related dysfunction

Chaib et al. identify PD-L2 as a senescence-associated immune checkpoint that promotes senescent cell persistence during aging; soluble PD-L2 also increases with aging and declines after senolytic...

cell.com
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Completely new way of curing incurable blood disease using mRNA engager that makes T cells kill B cells cell.com/cell/fulltext/S0092…

mRNA-encoding CD19-targeting T cell engager for refractory immune thrombocytopenia

An mRNA-lipid nanoparticle-encoded CD19×CD3 T cell engager depletes B cells with attenuated cytokine release in preclinical models. In three patients with treatment-refractory immune thrombocytopen...

cell.com
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Tumor immune microenvironment remodeling predicts response to checkpoint inhibitor therapy dlvr.it/TVY5ff
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Plasticity of the infant immune system during the perinatal period dlvr.it/TVXqvS

Plasticity of the infant immune system during the perinatal period

Nature Reviews Immunology - Immune plasticity during the perinatal period enables mammalian offspring to successfully navigate the transition from prenatal, intrauterine life to postnatal,...

nature.com
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This is a major milestone in the age of AI and toward our ultimate goal of completely reversing aging! @InSilicoMeds developed the first AI drug, Rentosertib, now in a Phase 3 clinical trial, and it just showed something remarkable: a reversal of biological age in people! Six different aging clocks, developed by six independent groups, all showed reversal after just 12 weeks of treatment, with participants measuring 3–4 years younger biologically! Congratulations to my friend Alex and the entire @InSilicoMeds team on this landmark achievement!
Alex Zhavoronkov, PhD (aka Aleksandrs Zavoronkovs)
@biogerontology
Sep 7
My dear friends, I am happy to report the publication of the most important paper in my life to date (we have several great papers coming out but this is very special). Tomorrow, I will present this paper for the first time at the Nature AI Healthcare in Paris and will post a longer post on this story and its broader implications for how to conduct clinical trials. Please read it and comment on it. Many thanks to the great co-authors of the study and everyone who contributed. Many thanks to the many reviewers (friendly and unfriendly) for spending so much time and helping make it better. Link in the comments.
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Increasing cytosolic NADPH to mimic exercise dlvr.it/TVND7V

Increasing cytosolic NADPH to mimic exercise

Nature Metabolism - In this issue of Nature Metabolism, Wu et al. reveal that cytosolic NADPH, a pentose phosphate pathway metabolite, drives a physiological cardiac hypertrophic response that is...

nature.com
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The most exciting paper I ever read.... Makes me wonder if there is any truth to cardiac donors having memories from the recipient?? frontiersin.org/journals/int…

Frontiers | The brain is not mental! coupling neuronal and immune cellular processing in human...

Significant efforts have been made in the past decades to understand how mental and cognitive processes are underpinned by neural mechanisms in the brain. Th...

frontiersin.org
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Gut microbiota-derived imidazole propionate promotes primary sclerosing cholangitis via p38 signalling dlvr.it/TVKKRx

Gut microbiota-derived imidazole propionate promotes primary sclerosing cholangitis via p38...

Nature Metabolism - The gut microbial metabolite imidazole propionate (ImP) is shown to promote primary sclerosing cholangitis (PSC) in mice. In humans with PSC, circulating ImP levels are elevated...

nature.com
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We recently learned that blood monocytes replace brain microglia immune cells beginning around age 50. Today, it's blood T cells infiltrate the brain to promote inflammation and Alzheimer's disease in the mouse model @NatureNeuro nature.com/articles/s41593-0…

Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration

Nature Neuroscience - The authors identify peripheral dendritic cell priming of T cells as a key driver of brain inflammation and neurodegeneration in a mouse model of tauopathy, providing new...

nature.com
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Online Now: Tumor immune microenvironment remodeling predicts response to checkpoint inhibitor therapy dlvr.it/TVHx5y

Tumor immune microenvironment remodeling predicts response to checkpoint inhibitor therapy

Lin et al. assemble a longitudinal pan-cancer single-cell atlas that tracks how the tumor immune microenvironment remodels during checkpoint inhibitor therapy. They show that the direction of...

cell.com
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The senescence-stiffening loop: Extracellular matrix remodeling, hypoperfusion, and mitochondrial dysfunction drive tissue aging dlvr.it/TVHnlb
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Immune surveillance and immune evasion of senescent cells | Nature Reviews Immunology nature.com/articles/s41577-0…

Immune surveillance and immune evasion of senescent cells

Nature Reviews Immunology - This Review outlines the context-dependent mechanisms that determine the immune surveillance or immune evasion of senescent cells and how targeting these immune-mediated...

nature.com
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A state-of-the science 5 ★ review of MASH (fatty liver with inflammation, nonalcoholic). Awareness of this important, highly prevalent, often undiagnosed condition has increased in recent years, and now the interventions to go after it have blossomed (Figure) @Nature @CancerInflam @GallageSuchira nature.com/articles/s41586-0…
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Nutrient-sensing pathways in adult stem cells: Orchestrating homeostasis, aging, and disease sciencedirect.com/science/ar…
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A brief guide to the identification and characterization of secreted molecules dlvr.it/TVFc4M

A brief guide to the identification and characterization of secreted molecules

Nature Metabolism - Secreted molecules are central regulators of interorgan communication and metabolic physiology. As the field has expanded rapidly, criteria for assigning molecules as bona fide...

nature.com
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Taner retweeted
htw@heniek_htw
Aug 31
Plasma multi-omics profiling reveals unique precursors of post-COVID cognitive decline during clinical recovery in older patients sciencedirect.com/science/ar…
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Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse brain white matter nature.com/articles/s43587-0…

Spatial mapping and senolytic targeting of senescent and disease-associated microglia in aged mouse...

Nature Aging - Carver and colleagues profile the aged mouse brain using spatial transcriptomic and imaging analysis and identify a senescence- and disease-associated microglial-linked state...

nature.com
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Online Now: dsRNAscan maps human dsRNAome, revealing conservation, intermolecular dsRNA, and correlates of ADAR dependency dlvr.it/TVCx1m
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