@HariharanLab
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We study growth, regeneration and cancer biology using the fruit fly Drosophila melanogaster
Berkeley, CA
Joined November 2015
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Today we completed 30 yrs as a lab - 12 at @MGHCancerCenter @harvardmed and 18 at @berkeleyMCB Thanks to all current and former lab members! Sixteen of them (17 soon) are running their own labs! I presented at lab meeting (outdoors) and lab peeps provided cupcakes and props.
Iswar Hariharan, ईश्वर हरिहर, ஹரிஹரன் ஈஸ்வரன் retweeted
MCB's Priya Moorjani & her lab have developed a novel genomic analysis method that identified DNA inherited from two previously unknown ancient human relatives, providing new insights into the complexity of human evolution.
news.berkeley.edu/2026/07/30…
Exactly 57 years ago, followed the moon landing with great anticipation from a small town in India by radio and newspaper. Was thrilled to stay up late & watch the livestream of the @SkyrootA rocket going into orbit. Great coverage!
The most memorable day of test cricket, ever. Was able to get the audio of the TV commentary on my dial up AOL internet connection. Remember staying up until morning in Boston to follow this.
25 years ago at Eden Gardens Rahul and I shared a partnership that will forever remain special. In a moment when the game looked beyond us we chose belief, patience and resilience. That stand was not just about runs but was about trust, teamwork and fighting for every session. Grateful to have shared that journey with Rahul and to be part of a Test that reminded us all that in cricket comebacks are always possible👍 @BCCI #PowerOfPartnership #Believe #Resilience
I was there at the MCG! For the final, as well as an earlier round India vs Aus game. After surviving the obvious caught behind in the final, Imran was run out by a direct hit by Gavaskar.
Azhar just about holding on to Mohsin Khan's catch off Kapil, Sadanand Vishwanath stumping Javed Miandad off a beauty from Siva, Imran surviving a clear caught behind off Chetan Sharma.
And then Srikkanth thrashing the bowling around while Ravi Shastri just anchored the innings and assured himself the Player of the tournament award and the Audi car.
If the 2024-2026 Indian T20I team is perhaps the best ever, India has never been as dominant in ODIs as they were in that World Championship of Cricket which they won on this day, 41 years ago in Melbourne
Iswar Hariharan, ईश्वर हरिहर, ஹரிஹரன் ஈஸ்வரன் retweeted
How P. Balaram and Isabella Karle’s work contributed to the structural foundation of the wave of GLP-1 agonists. An excellent post by @curiouswavefn (I suspect he is an institution and not a person; given the breadth and depth of his posts; though this one is right up his alley)
New post: The unsung heroes of GLP-1 agonist therapies. How
Padmanabhan Balaram and Isabella Karle laid the basic structural foundations for today's revolutionary drugs medchemash.substack.com/p/th…
In 2005 Steve Martin, Kunxin Luo and I taught a new undergraduate course “The Biology of Human Cancer”. Last week course alumni @Joanna_Y_Lee and @DanNomura (2005) and @DarienReedMDPhD (2006) returned to tell us about their career paths after the course. Students were inspired!🙏🏽
David Baltimore had an amazing intellect! I first interacted with him when I was a graduate student in Australia. Here is a photo of David and me in a cricket match in the Australian bush.
Now online! Remembering David Baltimore (1938–2025) dlvr.it/TNxrHN
After being with us for almost 13 years, Sunshine passed away yesterday. She was possibly the first dog to publish her research on Twitter - she was well ahead of @mbeisen in adopting the “publish and then review” model.
Iswar Hariharan, ईश्वर हरिहर, ஹரிஹரன் ஈஸ்வரன் retweeted
Issue 15 is complete!
On the cover: When echinoid (ed) mutant clones (white) and wild-type twin clones (red) are generated in the developing Drosophila eye (right), the mutant tissue is eliminated. See Research Article by Spitzer et al.
journals.biologists.com/dev/…
ALT When echinoid (ed) mutant clones (white) and wild-type twin clones (red) are generated in the developing Drosophila eye (right), the mutant tissue is eliminated. However, if wild-type twin clones are removed so that most eye tissue is mutant (left), the ed mutant cells survive and the eyes overgrow. See Research Article by Spitzer et al.
A great thread by Vijay @kvijayraghavan on Dr. P. Babu that includes lots of lovely details on early studies of the wingless gene and cell fate determination in Drosophila imaginal discs.
Professor Padmanabhan Babu has—in his quiet and understated manner—had an important impact on developmental biology, only one aspect of which was the isolation of the lin-4 mutant allele (e912), highlighted below in the post by Richard Behringer @rrbehringer and the Society of Developmental Biology. Moving from theoretical physics to developmental genetics, his contributions ranged from studies on the roundworm C. elegans and the fly Drosophila melanogaster. Then, abruptly setting aside his academic interests, he started the first company in India making restriction enzymes and polymerases, seeding the growth of the biotech industry and making these reagents available widely in India. He then made another leap, starting a company to manufacture lactose-free milk.
I’m sure Vijay @kvijayraghavan can add more on Dr. Babu’s contributions to Drosophila developmental biology eg wingless.
For many years there was only one lin-4 mutant allele (e912) #Celegans which enabled studies reported by Lee et al. 1993, describing 1st microRNA. e912 was isolated by P. Babu in Cambridge, UK. See The Backstory on Dr. Babu. bit.ly/4mAJrZ1 @wormbase @SocDevBio @InSDB_79
Iswar Hariharan, ईश्वर हरिहर, ஹரிஹரன் ஈஸ்வரன் retweeted
Fundamental discoveries in developmental biology & their impact on biomedical research. A set of 12 talking points highlighting dev biol discoveries can be downloaded from @SocDevBio webpage as ppt slides & posters. bit.ly/3H86pbc
Iswar Hariharan, ईश्वर हरिहर, ஹரிஹரன் ஈஸ்வரன் retweeted
The cell-adhesion molecule Echinoid promotes tissue survival and separately restricts tissue overgrowth.
Read this #OA Research Article by Danielle Spitzer, William Sun, Anthony Rodríguez-Vargas @arodz_var, and Iswar Hariharan:
journals.biologists.com/dev/…
ALT Fig. 3. echinoid clones are generated and then die, especially when more wild-type tissue is present. (A-F) Wing discs containing GFP-marked clones expressing either UAS-w-RNAi (A,C,E) or UAS-ed-RNAi (B,D,F). Heat shocks of 12 min (A,B), 15 min (C,D) and 30 min (E,F) generate clones at progressively higher density. Scale bar in A applies to A-F.
Iswar Hariharan, ईश्वर हरिहर, ஹரிஹரன் ஈஸ்வரன் retweeted
While Gokul for all intents and purposes IS the ABC, I thought he deserves his own shout out, since none of this would have been possible without him: journals.biologists.com/jcs/…
Finally here! Our preprint on the MOSAIC, a multimodal adaptive optical microscope enabling non‑invasive in‑vivo imaging from molecules to organisms, is out.
biorxiv.org/content/10.1101/…
@Eric_Betzig @legant_lab
Congratulations Varadha!
Excited to share our latest work in Molecular Biology of the Cell! We show how the M. tuberculosis lipid SL-1 activates the mechanosensitive channel TRPV4, setting off a signaling cascade that enhances lysosomal biogenesis and exocytosis in macrophages. 🧵doi.org/10.1091/mbc.E24-12-0…
