#cryoEM enthusiast now also at @haselbachlab@mstdn.science
Wien, Österreich
Joined January 2011
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Haselbach lab retweeted
The annual Cryo-EM Symposium took place on Campus this year. It is collaboratively organized by the Vienna BioCenter & ISTA and aims to explore & celebrate the latest advancements in Cryo-EM research & its impact on biological studies. Thank you to everyone joining!
Haselbach lab retweeted
I have stopped posting on social media, but this is a special occasion. I am glad to share that our work has been published in Science Advances! We made it work through great collaborations with outstanding colleagues. science.org/doi/10.1126/scia…
Haselbach lab retweeted
To regulate gene activity, proteasomes - waste disposal machines of cells - must enter the nucleus. IMP Researchers now show how the adaptor protein AKIRIN2 helps ferry this massive complex through the nuclear pore: nature.com/articles/s41467-0…
Haselbach lab retweeted
We introduce a new method, EmbedOpt, for robustly steering protein sequence-to-structure diffusion models to fit experimental data (Cryo-EM, NMR) without training. 🧬📉 @mhli41 @JiequnH @PilarCossio2
EmbedOpt tackles the brittleness of the previous coordinate-space steering methods by optimizing the conditional embedding instead. These embeddings capture rich co-evolutionary signals in protein diffusion models—unlocking a new, robust and semantically meaningful diffusion steering axis.
🚀 Result: Better fitting, wider hyperparam stability, and efficiency enabled by fewer diffusion steps
📄 Preprint: arxiv.org/abs/2602.05285
Haselbach lab retweeted
Sven Klumpe, joint Group Leader at the IMP and IMBA has received a grant by the Chan Zuckerberg Initiative’s Biohub to support fibsem-os, an open-source software platform for focused ion beam–scanning electron microscopy.
Read more 👉 imba.science/4tiwEP9
Haselbach lab retweeted
New work from our Haselbach lab with collaborators captures ribosomes 𝘮𝘪𝘥-𝘣𝘶𝘪𝘭𝘥 and reveals a flexible, modular strategy behind their assembly, rather than a strict assembly line.
Published in _Nucleic Acids Research _👉 doi.org/10.1093/nar/gkag036
Haselbach lab retweeted
🌍Open call: Junior Group Leader positions!
Join a world-class biomedical research institute at the heart of the Vienna BioCenter, where curiosity drives discovery.
Lead your own lab, pursue bold ideas, and shape the future of science at the IMP: imp.ac.at/career/open-positi…
Haselbach lab retweeted
How do cells decide on the life or death of a protein?
🔬 Researchers around @HaselbachLab at the IMP have captured the first high-resolution view of the human proteasome reading different ubiquitin signals.
➡️Read the full story: imp.ac.at/news/article/how-c…
Haselbach lab retweeted
Passionate about structural biology and #biochemistry? Join David Haselbach’s group through the Vienna BioCenter #PhD Program (@TrainingVbc)!
⏳ Deadline: April 15, apply now: training.vbc.ac.at/phd-progr…
📷Watch David's 'Scientist Snapshot': youtube.com/watch?v=DXTOW3P5…
Haselbach lab retweeted
Congrats to @HannaBrunner_ PhD (@HaselbachLab), who recently defended her thesis: "The nuclear import of human proteasomes and the functional role of AKIRIN2". Well done Hanna! 🥂🍾 @univienna @IMPvienna @IMBA_Vienna @gmivienna @MaxPerutzLabs
Haselbach lab retweeted
Finally, my postdoc work is published in Cell Structure! 🎉 Grateful for the chance to apply deep learning to cryo-ET and learn from @HaselbachLab about structural biology🦠. Huge thanks to Lukas Herrmann for coding help and @GrohsPhilipp for my position and all the GPUs.
🔬Our @HaselbachLab with @HararPavol have developed ‘FakET’!
The new method creates ‘fake’ electron microscopy images to train AI, reducing manual work in particle identification.
Read the full story: imp.ac.at/news/article/faket…
#AI #ArtificialIntelligence #microscopy #cryoem
Haselbach lab retweeted
🔬Our @HaselbachLab with @HararPavol have developed ‘FakET’!
The new method creates ‘fake’ electron microscopy images to train AI, reducing manual work in particle identification.
Read the full story: imp.ac.at/news/article/faket…
#AI #ArtificialIntelligence #microscopy #cryoem
Haselbach lab retweeted
Extremely excited to be joining the vibrant community of the Vienna BioCenter to build up cryo-ET and cryo-FIB milling on campus soon!
IMBA and the @IMPvienna will soon host a joint research group headed by Sven Klumpe. The structural biologist will join both institutes with an innovative double-affiliation to add cryo-Electron Tomography research on “jumping genes” and other fields to the @viennabiocenter campus. More: bit.ly/411CWH5
Haselbach lab retweeted
🆕 #preprint by Karagoz lab & us on the crosstalk between #UFMylation & #RQC (ribosome-associated quality control) biorxiv.org/content/10.1101/… As always let us know what you think!
Haselbach lab retweeted
Registration is now open for EMBO Workshop on Protein quality control: From molecular mechanisms to aging and disease 18 – 23 May 2025 in Hersonissos, Greece
📜 Early bird registration deadline: 31 Jan 2025
meetings.embo.org/event/25-p…
#EMBOproteinQualityControl
Haselbach lab retweeted
NEW #Preprint on #ATG8 specialization in #autophagy in #plants: biorxiv.org/content/10.1101/… A short 🧵
Haselbach lab retweeted
A multivalent adaptor mechanism drives the nuclear import of proteasomes biorxiv.org/cgi/content/shor… #biorxiv_molbio
Haselbach lab retweeted
CZII’s particle picking machine learning challenge is up and running. There are already 1000 signups on Kaggle. Follow this page for an introduction and links to all sorts of material and resources, including two preprints: cryoetdataportal.czscience.c…
Haselbach lab retweeted
David Haselbach @HaselbachLab (@IMPvienna group leader) is taking part in the 2nd edition of our #leadership program. training.vbc.ac.at/leadershi… @IMBA_Vienna @gmivienna @viennabiocenter @VBCF_Tweets
Haselbach lab retweeted
David Haselbach @HaselbachLab (@IMPvienna group leader) is taking part in the 2nd edition of our #leadership program. training.vbc.ac.at/leadershi… @IMBA_Vienna @gmivienna @viennabiocenter @VBCF_Tweets