@HealthFamMan
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💡 Health tech pioneer, travel enthusiast, and family man 🐱⛳
Edinburgh
Joined March 2023
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Jack the Startup Father retweeted
No you should not give FB your data.
But also, good discourse
So @Muse said it only searched gmail when I asked. But it scanned my email daily without permission, then made up explanations twice when I caught it. No setting to stop the surveillance — only a kill switch for Gmail completely.
Jack the Startup Father retweeted
NEW
"This is a really special gift to commemorate my win here last year"
Special portrait for Bob MacIntyre and Dunhill Links trophy photo as well in iconic St Andrews venue
@ScotsmanSport
@robert1lefty
@TheHomeofGolf
@dunhilllinks
scotsman.com/sport/special-p…
Jack the Startup Father retweeted
This is a big deal in Investigational New Drug (IND) applications. It is now possible to reduce the time it takes to submit these from 3–4 months to a month; soon it’ll be down to days, greatly accelerating new drug submissions for clinical trials & saving tens of millions of $!
Writing an Investigational New Drug (IND) application is a major hurdle for drug developers. It can take a team of specialists three to four months, and mistakes can trigger protocol amendments or clinical holds.
In June, we started working with Population Health Partners (PHP) to leverage specialized Kosmos Clinical Protocol Design (“CPD”) and Kosmos Regulatory Authoring (“RA”) products to support PHP’s process of IND preparation.
Since then, specially trained Kosmos products produced a first acceptable draft of the Nonclinical Overview in 4.2 hours, against 100 hours of expert time, flagged an error that roughly fifteen human reviewers missed, and authored 70% of the text in a Pre-IND Briefing Meeting Request submitted to FDA.
PHP is now bringing Kosmos products to a second program and expects to complete IND preparation in as little as 1 month, instead of the 4 month industry standard.
PHP's experts can spend their time reviewing and deciding, not just drafting. The time recovered by Kosmos products means that drugs could make their way to patients faster.
Jack the Startup Father retweeted
I don’t just blame phones. It’s also parenting is more absorbing, work is constant, both parents are required to pull long hours.
Planning a dinner party is sadly low on the list versus homework, school paperwork, doctors’ appointments etc.
New newsletter: THE DEATH OF THE AMERICAN HOST
The share of Americans who say they host friends or family at their home at least monthly has declined by 70 percent in the last 50 years.
derekthompson.org/p/the-deat…
Jack the Startup Father retweeted
I’m no economist, I have a basic knowledge at best.
Maybe it’s just bad news bias, but the UK outlook feels bleak to me.
- The FTSE 100 is at a 3-month low
- Inflation is up to 3.1%, 4% expected early next year.
- Energy costs are surging with diesel heading for £2 a litre
- 10-year gilt yields are around 5.45%, the highest since 2007.
On top of that, more high earners are reportedly leaving.
If this keeps going, are we heading for a recession, or am I blowing the figures out of proportion?
Jack the Startup Father retweeted
Data about how referrals are made still feels like the most underutilized dataset in healthcare.
Being able to understand the referral patterns from a certain doctor or to a certain doctor/hospital can help inform a lot about how the healthcare system gets used, understand why certain choices are made, and potentially intervene if the referral is a wrong fit.
But referral data is largely dark matter that exists in a liminal space between the two providers. It’s inferred from other datasets like claims or EHR notes, but it misses a lot of the nuance that’s actually sent in the referral transmission. But if this data can be captured and structured easily now, I think it can be a really valuable dataset.
Here is an interesting study. Within a health system, when primary care makes a referral to a specialist only 35% had a documented completed appointment. But looking at the methods, every out-of-network referral automatically shows as "no status" (~10% of referrals) because Duke's Epic can't see what happens at a non-Duke specialist. Another massive chunk (~20%) of tickets had no date because schedulers booked appointments without linking them back to the original order.
Just goes to show how hard it is to do analyses with our current available data, especially across providers.
Jack the Startup Father retweeted
At DevDay, OpenAI announced:
- Their answer to Muse and Grokbot: Dots (although not free like Muse)
- Their answer to Anthropic’s latest models: GPT-6.1-Sol
- Their answer to Jev: The decision API
They also announced ChatGPT Spaces and Ultrafast mode (at 6x cost) as well as everything being available in the cloud and an agents API (with computer use).
Jack the Startup Father retweeted
Is the man high?
You can’t my friend cos energy prices are 4x higher here than elsewhere.
You can’t because you need 5 years and more regulation than ever to open a datacentre.
You have to create the environment and ecosystem for AI to thrive. And we haven’t.
Jack the Startup Father retweeted
Wire-to-wire to finish P1 in Monza. 🏆
Casandra Alexander put on a show in Italy with her Pro V1 golf ball and 14 Titleist clubs, winning the #LadiesItalianOpen by three shots and further extending her lead in the @LETGolf Order of Merit.
Swipe to see her WITB. ➡️
#TeamTitleist
Jack the Startup Father retweeted
A student loan now takes 9% of everything earned over £25,000, for forty years.
It comes off before the money lands, on top of income tax and National Insurance, and the balance grows with interest the whole time. Most people will never clear it before it gets written off at the end.
Forty years is longer than the mortgage most of them won't be able to get.
Jack the Startup Father retweeted
In Jensen's 5 layer cake analogy for AI (energy, chips, infrastructure, models, applications), the middle layer (esp the software infra part) is much less understood - and thats where @VAST_Data became a $30B company few people know about, powering @SpaceXAI, @CoreWeave, @nebiusai, @MistralAI, @nscale etc
My conversation with Renen Hallak, CEO:
00:00 Intro
00:51 The hidden software layer in NVIDIA's AI stack 02:28 What actually makes an "AI factory"?
05:13 Should Walmart and Goldman build their own AI?
06:20 "We infer during the day, fine-tune at night"
13:16 Announcement: frontier models & sensitive data
15:32 From P vs. NP to founding VAST Data
17:32 OpenAI, Navier–Stokes and 10,000 agents
20:25 The pre-transformer insight behind VAST
21:55 DASE: VAST's "shared everything" architecture
25:18 "Storage was where startups go to die"
27:39 Trillions of vectors: why old databases break
29:01 Are S3, Snowflake and Databricks ready for AI
31:29 Data gravity, vendor lock-in and zero churn
33:13 Training vs. inference: why the infrastructure changes
34:46 Model routing, KV caches, RAG & agent memory
36:59 Identity, permissions and security for AI agents 40:27 Can multi-agent systems unlock scientific discovery?
41:55 DataEnclave: how confidential AI protects data and weights
45:16 Who should be AI's trust layer?
46:37 "Sometimes it scares me": 500 petabytes to 2 exabytes
50:08 Is circular AI financing creating systemic risk
51:32 Why VAST is profitable when AI infra isn't
53:24 What separates the winning neoclouds?
55:06 "Their lunch is being eaten": why hyperscalers lag
59:10 Where will the trillions accrue across the AI stack
1:01:18 NVIDIA: "There's no legal document between us"
1:03:59 What VAST learned from xAI and @elonmusk
1:05:36 "Bad things loudly and often": building at AI speed
1:06:53 More change in 10 years than the previous 1,000?
1:08:39 VAST's endgame: all the data in the world
Jack the Startup Father retweeted
If AI is making it easier to build a company, I hope we get millions more people solving wonderfully specific problems.
Better tools for nurses, better tools for our aging parents, software no one is thinking about. The possibilities are endless!
Jack the Startup Father retweeted
Wages are the most heavily taxed way to receive money in this country.
Income tax up to 45%, with National Insurance on top of it. Money that arrives from owning something instead — dividends, or an asset sold at a gain — is taxed at noticeably lower rates.
The system is built to reward owning. Almost everybody is set up only to earn.
Jack the Startup Father retweeted
I have a secret for you, don’t tell anybody 😉
You can cover a lot of the mobility demands in the golf swing with just this exercise.
Internal hip rotation & thoracic spine rotation.
Golf is easier when you have both.
15 reps, switch legs & rotation direction.
Repeat daily.
Jack the Startup Father retweeted
Two fascinating cancer breakthroughs are happening at same time.
First, a engineered probiotic bacteria attack 43% of colorectal tumors in mice.
This bacteria can produce chemotherapy inside tumors while also activating the immune system.
In mice, this treatment completely eliminated 3 of 7 tumors — ~43%.
Then, in another study, a drug wiped out all detectable disease markers in 78% of high-risk patients before they developed full-blown multiple myeloma.
Researchers tested teclistamab in people with high-risk smoldering multiple myeloma, a precursor to active multiple myeloma.
As a result, 77.8% of patients achieved a complete response or better.
At 24.5 months, 92% remained progression-free.
That indicates cancer treatment is getting more programmable day by day.
Jack the Startup Father retweeted
Large Drug Discovery Model is out! I am exited to introduce our new generative SBDD framework. We experimentally validated LDDM across 5 targets and successfully designed novel, validated hits with structural accuracy confirmed by X-ray.
Preprint: biorxiv.org/content/10.64898…
🧵 1/7
Jack the Startup Father retweeted
Sales leader friend at one of the payer AI companies sold triple his quota in 6 months.
The payer momentum on coding review and denial solutions to keep up with the provider AI tooling is unbelievable.
But I think the more interesting thought is to predict what happens in a few years when provider and payer AI is perfectly coding and utilization managing every claim --> I expect more payers to go into APMs or direct contracting with providers as one of their last remaining options in managing expense.
Jack the Startup Father retweeted
Just logged into my @HLInvest App and was given my monthly digest.
A new feature to summarise how my investments performed last month.
Always interesting to see this type of data. Hope they start delivering more features like this…
Jack the Startup Father retweeted
"What human extinction taught me about selling B2B SaaS"
Live: @DarioAmodei x @Benioff
The @AnthropicAI co-founder & CEO joins us at @Dreamforce for a conversation worth hearing ☁️